Feasibility of Proniosomes-Based Transdermal Delivery of Frusemide: Formulation Optimization and Pharmacotechnical Evaluation

Azeem, Adnan; Jain, Neeraj; Iqbal, Zeenat; Ahmad, Feroz; Aqil, Mohd.; Talegaonkar, Sushama

doi:10.1080/10837450701831211

Cited by 24 publications

(8 citation statements)

References 25 publications

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“…Similarly, the amount of drug retained within the skin was determined by taking out the skin from the diffusion cell and extracting the drug using a mobile phase. It was stirred for 12 h and then centrifuged at 5000 rpm for 20 min (Bhatia et al, 2004;Azeem et al, 2008). The supernatant was filtered through a 0.4 µ membrane filter and analyzed for drug content by HPLC method, as reported earlier by Wattananat and Akarawut (2006).…”

Section: Skin Permeation Studymentioning

confidence: 99%

Development and characterization of oleic acid vesicles for the topical delivery of fluconazole

Zakir¹,

Vaidya²,

Goyal³

et al. 2010

Drug Delivery

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Fatty acids have been widely used as adjuvant, vehicles in drug delivery viz penetration enhancers in topical delivery and in polymeric micelles to provide sustained release. However, the present investigation aims at exploring the potential of fatty acid vesicles for the topical delivery of fluconazole. Vesicles were prepared by film hydration method using oleic acid as a fatty acid principal component. Developed vesicles were characterized for size, size distribution, shape, in vitro release, pH dependent and storage stability, skin irritation study, and ex-vivo skin permeation. Penetration behavior of vesicles was further evaluated and elucidated using confocal microscopic study. Optical microscopy and TEM studies confirmed vesicular dispersion of fatty acid. The vesicles possessed higher entrapment efficiency (44.11%) with optimum vesicle size and homogeneity in regard to size distribution (PDI = 0.234 +/- 0.016) at 7:3 oleic acid-to-fluconazole ratio. In vitro drug release study suggested sustained release of drug from the vesicles. The release pattern followed Higuchian kinetics. The vesicles were fairly stable at refrigerated conditions. Ex-vivo skin permeation and confocal microscopic studies suggested that oleic acid vesicles penetrate the stratum corneum and retain the drug accumulated in the epidermal part of the skin. On the basis of sustained release behavior and skin retention it can be inferred that oleic acid vesicles can serve as a potential carrier for the topical localized delivery of bioactives.

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Section: Skin Permeation Studymentioning

confidence: 99%

Development and characterization of oleic acid vesicles for the topical delivery of fluconazole

Zakir¹,

Vaidya²,

Goyal³

et al. 2010

Drug Delivery

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“…The permeability and drug delivery related concerns of FRS have been addressed using various formulation maneuvers. The recent studies employing nanosuspensions, 18 chitosan coated liposomes, 19 colloidal carriers (niosome encapsulated selfmicroemulsifying drug delivery system), 20 polyamidoamine dendrimer complexes, 21 proniosomes, 22 supramolecular complexes, solid dispersion, co-crystals, and micro-emulsions are well documented in literature. [23][24][25][26] The rst objective of this investigation was to develop and validate a bioanalytical method to estimate the pharmacokinetics of FRS loaded SLN (FSLN) and FRS suspensions (FSP) using the RP-HPLC method.…”

Section: Introductionmentioning

confidence: 99%

In vitro–in vivo and pharmacokinetic evaluation of solid lipid nanoparticles of furosemide using Gastroplus™

et al. 2017

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“…Proniosome-derived niosome dispersion is obtained by hydrating proniosome preparation with 80°C distilled water and vortex mixing for 2 min. [51][52][53][54] Advantages [50,55,56] The advantages are simple method and suitable for hydrophobic drug without concerns of instability or susceptibility of active pharmaceutical ingredient to hydrolysis.…”

Section: Slow Spray Coating Methodsmentioning

confidence: 99%

Proniosome: A Novel Non-Ionic Provesicules as Potential Drug Carrier

Bachhav¹

2016

AJP

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Vesicular systems are a novel means of drug delivery that can enhance the bioavailability of encapsulated drug and provide therapeutic activity in a controlled manner for a prolonged period of time. Liposomes were the first such system, but they suffer from a number of drawbacks including high cost and lack of stability at various pHs. To avoid the drawback of liposomes, niosomes were invented, which can be easily and reliably made in the laboratory. Niosomes are the ideal means of drug delivery that can enhance the bioavailability of encapsulated drug by various mechanisms and provide a therapeutic activity for a prolonged period of time. However, they suffer from aggregation, fusion, leaking, sedimentation of vesicles, and difficulty in sterilization; so to overcome these problems, a newer approach was employed which is known as pro-vesicular carriers. Here, in this review, we elaborate one of the pro-vesicular carriers, widely known as proniosome. This review covers all the aspects of proniosomes including mechanism, formulation variables and their effects, methods of preparation, parameters for characterizations, and application.

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Feasibility of Proniosomes-Based Transdermal Delivery of Frusemide: Formulation Optimization and Pharmacotechnical Evaluation

Cited by 24 publications

References 25 publications

Development and characterization of oleic acid vesicles for the topical delivery of fluconazole

Development and characterization of oleic acid vesicles for the topical delivery of fluconazole

In vitro–in vivo and pharmacokinetic evaluation of solid lipid nanoparticles of furosemide using Gastroplus™

Proniosome: A Novel Non-Ionic Provesicules as Potential Drug Carrier

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