Feasibility of Polyvinyl Alcohol as a Transdermal Drug Delivery System for Terbutaline Sulphate

Kumar, T. M. Pramod; Umesh, H. M.; Shivakumar, H. G.; Ravi, Valluru; Siddaramaiah,

doi:10.1080/10601320701283610

Cited by 16 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Poly(vinyl alcohol) (PVA) is a water‐soluble synthetic polymer that is nontoxic, biocompatible, and biodegradable . With its strong resistance to chemical and thermal treatments, PVA resin and chemically modified hydrogels have been used for many applications .…”

Section: Introductionmentioning

confidence: 99%

Electrospun poly(vinyl alcohol) composite nanofibers with halloysite nanotubes for the sustained release of sodiumd‐pantothenate

Lee

Chen

et al. 2015

J of Applied Polymer Sci

View full text Add to dashboard Cite

Poly(vinyl alcohol) (PVA) nanofibers containing halloysite nanotubes (HNTs) loaded with sodium D-pantothenate (SDP) were successfully fabricated via simple blend-electrospinning. SDP was efficiently loaded into the innate HNT lumen with an SDP/ HNT mass ratio of 1.5:1 via vacuum treatment. The SDP-loaded HNT-inclusion complex was evaluated with drug-loading efficiency testing, Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction. The morphologies of the nanofibers were observed by scanning electron microscopy, which revealed uniform and smooth surfaces of the nanofibers. The addition of HNTs to the composite nanofibers increased the viscosity of the polymer solution, and this suggested shorter fiber diameters. FTIR spectroscopy verified the good compatibility of the SDP and HNTs with PVA. Moreover, the swelling properties were found to quantitatively correlate with weight loss. In vitro drug-release testing revealed that the HNTs and crosslinking reaction most dramatically affected the sustained release of SDP from the PVA and SDP-loaded HNT complex. In the drug-release kinetics model, SDP release depended on the diffusion caused by the deformation of the polymer-based structures in the medium; it followed Fickian diffusion with acceptable coefficient of determination (r 2 ) values between 0.88 and 0.94. Most importantly, the HNTs as natural biocontainers effectively modulated the release profile by loading the active compound in harmony with the electrospun nanofibers.

show abstract

Section: Introductionmentioning

confidence: 99%

Electrospun poly(vinyl alcohol) composite nanofibers with halloysite nanotubes for the sustained release of sodiumd‐pantothenate

Lee

Chen

et al. 2015

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…As the world largest petroleum polymer on volume,1 poly(vinyl alcohol) (PVA) is a biodegradable and biocompatible synthetic polymer with high water solubility and crosslink ability (film or hydrogel forming) due to having hydroxyl groups in the polymer side chain. PVA posses some desirable properties for biomedical applications such as controlled drug delivery systems,2, 3 dialysis membrane,4 wound dressing,5 artificial cartilage,6 and tissue engineering scaffold 7. Although PVA has good mechanical properties in the dry state, the high hydrophilicity limits its scope of applications in wet state, that is, living environments 8.…”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol)/halloysite nanotubes bionanocomposite films: Properties and in vitro osteoblasts and fibroblasts response

Zhou

Guo

Liu

et al. 2009

J Biomedical Materials Res

131

View full text Add to dashboard Cite

In this study, transparent poly(vinyl alcohol) (PVA) and PVA/halloysite nanotubes (HNTs) bionanocomposite films were prepared by solution casting and glutaraldehyde (GA) crosslinking. The surface topography and chemistry of the films were characterized by atomic force microscopy (AFM) and attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, respectively. Blending with HNTs induced changes in nanotopography and surface chemistry of PVA films. The mechanical properties of PVA were enhanced by the incorporated HNTs. The stain-induced crystallization was confirmed by DSC after tensile test. MC3T3-E1 osteoblast-like and NIH 3T3 fibroblast cells were cultured on neat PVA and PVA/HNTs films to evaluate the effects of surface nanotopography and composition on cell behavior. The observations indicated that MC3T3-E1 cell behavior strongly responded to surface nanotopography. On nanotube-dominant surface, cells exhibited a significantly higher level of adhesion than on neat PVA film, whereas neat PVA showed higher degree of osteoblast proliferation compared with PVA/HNTs. In vitro fibroblasts response demonstrated that both neat PVA and PVA/HNTs nanocomposite films were biocompatible and PVA/HNTs films favored to fibroblasts attach and growth below 7.5 wt % of HNTs incorporated. In summary, these results provided insights into understanding of PVA and PVA/HNTs bionanocomposite films in potential applications in bone tissue engineering and drug delivery systems.

show abstract

“…On the other hand, in polyvinyl alcohol films prepared with propylene glycol, tensile strength has been found higher. Besides, in vitro release of the terbutaline sulphate, which is an active substance, has been found higher in the propylene glycol containing films (Kumar et al, 2007).…”

Section: Group Hydrophilic/lipophilic Plasticizermentioning

confidence: 99%

Plasticizers in Transdermal Drug Delivery Systems

Güngör¹,

Erdal²,

Özsoy³

2012

Recent Advances in Plasticizers

View full text Add to dashboard Cite

Feasibility of Polyvinyl Alcohol as a Transdermal Drug Delivery System for Terbutaline Sulphate

Cited by 16 publications

References 10 publications

Electrospun poly(vinyl alcohol) composite nanofibers with halloysite nanotubes for the sustained release of sodiumd‐pantothenate

Electrospun poly(vinyl alcohol) composite nanofibers with halloysite nanotubes for the sustained release of sodiumd‐pantothenate

Poly(vinyl alcohol)/halloysite nanotubes bionanocomposite films: Properties and in vitro osteoblasts and fibroblasts response

Plasticizers in Transdermal Drug Delivery Systems

Contact Info

Product

Resources

About