Electrospun poly(vinyl alcohol) composite nanofibers with halloysite nanotubes for the sustained release of sodium<scp>d</scp>‐pantothenate

Asadi

J of Applied Polymer Sci

2018

Bioactive wound dressings from poly(vinyl alcohol) (PVA) and zein nanoparticles (NPs) loaded with diclofenac (DLF) were prepared successfully by the single jet electrospinning method. DLF‐loaded zein NPs with an average diameter of ∼228 nm were prepared using anti‐solvent precipitation method. The formulation of zein:DLF 1:1 exhibited optimum encapsulation efficiency of 47.80%. The NPs were characterized by dynamic light scattering, zeta‐potential measurement, and differential scanning calorimetry. In vitro, drug release profiles of the DLF‐loaded zein NPs, and PVA–zein NPs were also studied within 120 h and showed the release efficiency of nearly 80% from zein NPs. A more controlled release of DLF was achieved by embedding the zein NPs in the PVA nanofibers. Fourier transform infrared spectroscopy was used to analyze possible interactions between different components of the fabricated dressings. The mechanical properties of the developed dressings were also evaluated using uniaxial tensile testing. Young's modulus (E) of the dressings decreased after inclusion of zein NPs within the PVA nanofibers. Moreover, fibroblast culturing experiments proved that the composite dressings supported better cell attachment and proliferation compared to PVA nanofibers, by exhibiting moderate hydrophilicity. The results suggested that the electrospun composite dressing of PVA nanofibers and zein NPs is a promising topical drug‐delivery system and have a great potential for wound healing application. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46643.

Section: Introductionmentioning

confidence: 99%

Zein nanoparticle‐embedded electrospun PVA nanofibers as wound dressing for topical delivery of anti‐inflammatory diclofenac

Asadi

J of Applied Polymer Sci

2018

“…Compared with PVA, the PVA‐nanocasted HNTs (Fig. 1 d ) appear as a characteristic peak at 19°, which should have originated from PVA [15]. This suggests that PVA nanocasted in nanopore channels of HNTs are likely to be achieved (Fig.…”

Section: Resultsmentioning

confidence: 99%

HNTs‐templated preparation of carbon nanorods by nanocasting method

Liu

Cheng

Liu

2017

Micro & Nano Letters

Carbon nanorods (CNRs) have been attracting increasing interest because of their potential applications in high-performance nanoscale materials and electronic devices. Among the many preparation methods, the nanocasting method via inorganic template materials exhibited a controllable and facile feature. This work was to present a novel preparation of CNRs through the nanocasting method using halloysite nanotubes (HNTs) as the template and polyvinyl alcohol (PVA) as the nanocasting carbon source. For the sake of PVA nanocasted in the hollow structure of HNTs, we adopted the repeated soakage method. The forming process and structure of CNRs were revealed by XRD, FT-IR, SEM, TEM, SAED XPS, Raman and Brunner-Emmet-Teller (BET) characterisation techniques. The results showed that the as-obtained CNRs with the rod-like structure had a high specific surface area of ca. 284 m 2 /g and exhibited typical mesoporous features.

J of Applied Polymer Sci

“…The description of the electrospinning apparatus was reported previously . Briefly, the prepared polymer solutions were ejected into a plastic syringe (NORM‐JECT, Luer Lock, Henke Sass Wolf, Germany).…”

Section: Methodsmentioning

confidence: 99%

Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility

Lee

Chen

et al. 2017

Self Cite

In this study, solid dispersions (SDs) and electrospinning combined methods were used to increase the bioavailability and solubility of a water insoluble drug. Pullulan (PUL) nanofibers containing rutin-Pluronic SDs (PUL&RU@PF) were fabricated by electrospinning. Rutin was efficiently loaded with Pluronic SDs using a facile mixing method and the prepared SDs indicated that 4% w/v Pluronic concentration provided the optimal drug loading efficiency. Scanning electron microscopy (SEM) verified that the morphology of the complex nanofibers had a uniformly smooth surface with a porous structure. The amorphous state of rutin was examined by XRD and DSC. Moreover, rutin in the electrospun PUL-rutin-Pluronic complex structure displayed a fast release profile and equivalent antioxidant ability compared to that of raw rutin. In conclusion, PUL&RU@PF may be a promising alternative for enhanced solubility and UV stability with remaining rutin's inherent antioxidant ability.