Feasibility of polymer gel dosimetry measurements in a dynamic porcine lung phantom

Mann, P.; Witte, Maximilian; Armbruster, Steven; Runz, A.; Lang, Clemens; Breithaupt, Mareile H.; Berger, M.; Biederer, J.; Karger, Christian P.; Moser, T.

doi:10.1088/1742-6596/573/1/012079

Cited by 3 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight of these flasks were used to calibrate the gel and one served as the gel tumor. As there are numerous reports on gel polymerization inhibition characteristics by oxygen penetration as well as by chemical interactions between the gel and flask material (Baldock et al 2010, Vandecasteele and De Deene 2013c, Mann et al 2015, the selection of an adequate flask material was considered very critical. With this respect, BAREX ™ was found to be a suitable material as it consists of a thermoformable acrylonitrile-methyl acrylate copolymer with low oxygen permeability, high chemical stability and negligible interaction rate with other chemicals (Vergote et al 2004).…”

Section: Gel Fabricationmentioning

confidence: 99%

3D dosimetric validation of motion compensation concepts in radiotherapy using an anthropomorphic dynamic lung phantom

Mann¹,

Witte

Moser

et al. 2016

Phys. Med. Biol.

Self Cite

View full text Add to dashboard Cite

In this study, we developed a new setup for the validation of clinical workflows in adaptive radiation therapy, which combines a dynamic ex vivo porcine lung phantom and three-dimensional (3D) polymer gel dosimetry. The phantom consists of an artificial PMMA-thorax and contains a post mortem explanted porcine lung to which arbitrary breathing patterns can be applied. A lung tumor was simulated using the PAGAT (polyacrylamide gelatin gel fabricated at atmospheric conditions) dosimetry gel, which was evaluated in three dimensions by magnetic resonance imaging (MRI). To avoid bias by reaction with oxygen and other materials, the gel was collocated inside a BAREX container. For calibration purposes, the same containers with eight gel samples were irradiated with doses from 0 to 7 Gy. To test the technical feasibility of the system, a small spherical dose distribution located completely within the gel volume was planned. Dose delivery was performed under static and dynamic conditions of the phantom with and without motion compensation by beam gating. To verify clinical target definition and motion compensation concepts, the entire gel volume was homogeneously irradiated applying adequate margins in case of the static phantom and an additional internal target volume in case of dynamically operated phantom without and with gated beam delivery. MR-evaluation of the gel samples and comparison of the resulting 3D dose distribution with the planned dose distribution revealed a good agreement for the static phantom. In case of the dynamically operated phantom without motion compensation, agreement was very poor while additional application of motion compensation techniques restored the good agreement between measured and planned dose. From these experiments it was concluded that the set up with the dynamic and anthropomorphic lung phantom together with 3D-gel dosimetry provides a valuable and versatile tool for geometrical and dosimetrical validation of motion compensated treatment concepts in adaptive radiotherapy.

show abstract

Section: Gel Fabricationmentioning

confidence: 99%

3D dosimetric validation of motion compensation concepts in radiotherapy using an anthropomorphic dynamic lung phantom

Mann¹,

Witte

Moser

et al. 2016

Phys. Med. Biol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Phantoms produced by Kashani et al [Kashani 2007], Vinogradskiy et al [Vinogradsky 2009], Serban et al [Serban 2008] and Perrin et al [Perrin 2014] included a deformable lung, even more closely mirroring realistic patient anatomy. Others have attempted to use ex-vivo organs [Markel 2015], one of which was reported at the 4D workshop itself [Mann 2015].…”

Section: D Qa and 4d Dosimetrymentioning

confidence: 99%

Required transition from research to clinical application: Report on the 4D treatment planning workshops 2014 and 2015

et al. 2016

View full text Add to dashboard Cite

Since 2009, a 4D treatment planning workshop has taken place annually, gathering researchers working on the treatment of moving targets, mainly with scanned ion beams. Topics discussed during the workshops range from problems of time resolved imaging, the challenges of motion modelling, the implementation of 4D capabilities for treatment planning, up to different aspects related to 4D dosimetry and treatment verification. This report gives an overview on topics discussed at the 4D workshops in 2014 and 2015. It summarizes recent findings, developments and challenges in the field and discusses the relevant literature of the recent years. The report is structured in three parts pointing out developments in the context of understanding moving geometries, of treating moving targets and of 4D quality assurance (QA) and 4D dosimetry. The community represented at the 4D workshops agrees that research in the context of treating moving targets with scanned ion beams faces a crucial phase of clinical translation. In the coming years it will be important to define standards for motion monitoring, to establish 4D treatment planning guidelines and to develop 4D QA tools. These basic requirements for the clinical application of scanned ion beams to moving targets could e.g. be determined by a dedicated ESTRO task group. Besides reviewing recent research results and pointing out urgent needs when treating moving targets with scanned ion beams, the report also gives an outlook on the upcoming 4D workshop organized at the University Medical Center Groningen (UMCG) in the Netherlands at the end of 2016.

show abstract

Technical Note: Radiological properties of tissue surrogates used in a multimodality deformable pelvic phantom for MR‐guided radiotherapy

et al. 2016

View full text Add to dashboard Cite

show abstract

Feasibility of polymer gel dosimetry measurements in a dynamic porcine lung phantom

Cited by 3 publications

References 7 publications

3D dosimetric validation of motion compensation concepts in radiotherapy using an anthropomorphic dynamic lung phantom

3D dosimetric validation of motion compensation concepts in radiotherapy using an anthropomorphic dynamic lung phantom

Required transition from research to clinical application: Report on the 4D treatment planning workshops 2014 and 2015

Technical Note: Radiological properties of tissue surrogates used in a multimodality deformable pelvic phantom for MR‐guided radiotherapy

Contact Info

Product

Resources

About