Feasibility of hybrid TomoHelical- and TomoDirect-based volumetric gradient matching technique for total body irradiation

Abstract

Background: Tomotherapy-based total body irradiation (TBI) is performed using the headfirst position (HFP) and feet-first position (FFP) due to treatment length exceeding the 135 cm limit. To reduce the dosimetric variation at the match lines, we propose and verify a volumetric gradient matching technique (VGMT) by combining TomoHelical (TH) and TomoDirect (TD) modes. Methods: Two planning CT image sets were acquired with HFP and FFP using 15 × 55 × 18 cm 3 of solid water phantom. Planning target volume (PTV) was divided into upper, lower, and gradient volumes. The junction comprised 2-cm thick five and seven gradient volumes (5-GVs and 7-GVs) to create a dose distribution with a gentle slope. TH-IMRT and TD-IMRT plans were generated with 5-GVs and 7-GVs. The setup error in the calculated dose was assessed by shifting dose distribution of the FFP plan by 5, 10, 15, and 20 mm in the longitudinal direction and comparing it with the original. Doses for 95% (D95) and 5% of the PTV (D5) were calculated for all simulated setup error plans. Absolute dose measurements were performed using an ionization chamber in the junction. Results: The TH&TD plan produced a linear gradient in junction volume, comparable to that of the TH&TH plan. D5 of the PTV was 110% of the prescribed dose when the FFP plan was shifted 0.7 cm and 1.2 cm in the superior direction for 5-GVs and 7-GVs. D95 of the PTV decreased to < 90% of the prescribed dose when the FF plan was shifted 1.1 cm and 1.3 cm in the inferior direction for 5-GVs and 7-GVs. The absolute measured dose showed a good correlation with the calculated dose in the gradient junction volume. The average percent difference (±SD) in all measured points was − 0.7 ± 1.6%, and the average dose variations between depths was − 0.18 ± 1.07%. Conclusion: VGMT can create a linear dose gradient across the junction area in both TH&TH and TH&TD and can minimize the dose sensitivity to longitudinal setup errors in tomotherapy-based TBI.

Total marrow and lymphoid irradiation with helical tomotherapy: a practical implementation report

“…Helical TomoTherapy for magna-field irradiation offers a high degree of conformity, homogeneity of target coverage dose and significant sparing of OAR with optimal treatment efficiency, without the need for multiple junctions. This is possibly the reason why several groups have extensively evaluated it for TBI and TMI/TMLI [8,[10][11][12][13][14][15]. Recently volumetric modulated arc therapy (VMAT) has also been evaluated in this setting to a reasonable success [16].…”

Total marrow and lymphoid irradiation with helical tomotherapy: A practical implementation report

“…We preferred HT for magna-field irradiation as it offers a high degree of conformity, homogeneity of target coverage dose and significant sparing of OAR with optimal treatment efficiency, without the need for multiple junctions. This is possibly the reason why several groups have extensively evaluated it for TBI and TMI/TMLI [8][9][10][11][12][13][14]. Recently VMAT has also been evaluated in this setting to a reasonable success [15,16].…”

Hybrid Tomo‐Helical and Tomo‐Direct radiotherapy for localized prostate cancer

“…Tomo‐Helical (TH) mode provides a continuous 360° beam that may result in optimal dose distribution and dose conformity. 19 The Tomo‐Direct (TD) mode is a non‐rotational treatment option of the Tomotherapy platform and provides treatment at predetermined angles with a fixed gantry. 20 , 21 TomoHDA provides faster and better dose distribution with the new technology IDMS (integrated data management system) with Precision Planning System.…”