Feasibility of a Lifestyle Intervention on Body Weight and Serum Biomarkers in Breast Cancer Survivors with Overweight and Obesity

Campbell, Kristin L.; Patten, Cheri L. Van; Neil, Sarah; Kirkham, Amy A.; Gotay, Carolyn; Gelmon, Karen A.; McKenzie, Donald C.

doi:10.1016/j.jada.2011.10.022

Cited by 78 publications

(101 citation statements)

References 38 publications

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“…weeks, offered to BC survivors, also showed significant increases in VO 2peak (Campbell et al, 2012;Courneya et al, 2003;Herrero et al, 2006b;Scott et al, 2013) and PPO (Courneya et al, 2003;Herrero et al, 2006b). The magnitude of the changes varies across studies, probably due to A c c e p t e d M a n u s c r i p t 14 the heterogeneity of the studies in terms of time since last treatment, intervention duration, baseline CRF or age and menopausal status.…”

Section: Discussionmentioning

confidence: 98%

Is Quality of Life Related to Cardiorespiratory Fitness in Overweight and Obese Breast Cancer Survivors?

et al. 2015

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This study assessed changes in quality of life (QoL) and cardiorespiratory fitness (CRF) during a diet and physical activity (PA) intervention in breast cancer (BC) survivors and investigated the relation between these changes. The intervention of this single-arm pre-post study involved supervised, 1-hour weekly, diet sessions and 75-minute bi-weekly PA sessions of moderate-to-high intensity. This 12-week intervention targeted overweight/obese women who had recently completed BC treatment. Pre- and post-CRF and QoL measurements were compared using paired t-tests. Linear regression models, including baseline participants' characteristics and weight change, were used to assess the association between changes in CRF and QoL. The 37 BC survivors who completed the intervention between May 7, 2012 and July 27, 2012 showed significant increases in CRF and QoL. Peak oxygen uptake (mL/kg/min) increased from 19.0 ± 2.8 to 24.0 ± 4.1 while peak workload (watts/kg) increased from 1.3 ± 0.3 to 1.7 ± 0.3. Although statistical significance was not reached, the increase in workload seemed associated with increases in physical, mental, and general health and with a decrease in fatigue. This lifestyle intervention improved BC survivors' QoL and CRF and suggested possible relationships between CRF and QoL. More research needs to confirm these associations and promote lifestyle interventions aiming at improving BC survivors' QoL.

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Section: Discussionmentioning

confidence: 98%

Is Quality of Life Related to Cardiorespiratory Fitness in Overweight and Obese Breast Cancer Survivors?

et al. 2015

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“…17,18 Behaviorally based weight loss interventions for breast cancer survivors have resulted in weight losses ranging from 2.4%-13.9%. [19][20][21][22][23][24][25] However, dissemination of behaviorally based weight loss interventions for cancer survivors will require distantly delivered options. Technologies such as the Internet can be used to foster the intense monitoring and interactions needed for weight loss and has been successful among the general population.…”

Section: 16mentioning

confidence: 99%

Effectiveness of an Internet Delivered Behavioral Weight Loss Intervention Provided to Breast Cancer Survivors

L¹,

Y²,

D³

et al. 2015

AOWMC

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Abbreviations: BWL, behavioral weight loss; BMI, body mass index; AEE, activity-related energy expenditure; ANCOVA, analysis of covariance; SD, standard deviation; GED, general equivalency diploma; SEM, standard error of the mean IntroductionThe percentage of overweight or obese breast cancer survivors is 66% mirroring the general population. [1][2][3] Excess weight at diagnosis is often compounded by weight gain post therapy, especially among individuals who received chemotherapy 3,4 and exceeds the 3-5kg per decade gain observed in the general population.5 Additionally, the weight gained during treatment for breast cancer often results in increased body fat and loss of lean mass, or sarcopenia. [6][7][8] Breast cancer survivors with excess weight are at increased risk of recurrence as well as disease specific and overall mortality. 9-13The increased overall mortality among those with excess weight is a particular concern in women with early stage breast cancer who are likely cured of their breast cancer but may be at increased risk for chronic diseases, such as coronary heart disease. Because of the negative consequences associated with excess weight, the American Cancer Society has called for weight loss to be standard of care for overweight and obese breast cancer survivors. 14 Successful weight loss interventions emphasize behavior modification, energy restriction and increased physical activity. 15,16Among the general population, as well as those with and at risk for diabetes, this approach results in 7-10% weight loss. 17,18 Behaviorally based weight loss interventions for breast cancer survivors have resulted in weight losses ranging from 2.4%-13.9%. [19][20][21][22][23][24][25] However, dissemination of behaviorally based weight loss interventions for cancer survivors will require distantly delivered options. Technologies such as the Internet can be used to foster the intense monitoring and interactions needed for weight loss and has been successful among the general population. 26 However, an internet delivered intervention has not been tested with breast cancer survivors. Therefore, the aim of this study was to pilot test an Internet delivered behavioral weight loss (BWL) intervention among breast cancer survivors who did and did not receive chemotherapy. Primary outcomes were weight loss and anthropometric change. Secondary outcomes included change in energy balance parameters. We also explored difference in response to the intervention between women who did and did not receive chemotherapy. AbstractPurpose: Excess weight is associated with negative outcomes among breast cancer survivors. Our primary objective was to pilot test the value of an internet delivered behavioral weight loss (BWL) intervention for breast cancer survivors.Methods: Stage 0-III breast cancer survivors with excess weight who did (CHEMO) and did not receive chemotherapy (NO CHEMO) were recruited to participate. The 6month BWL intervention included behavior modification strategies, calorie reduction and an increase in moderate e...

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“…Multiple epidemiologic studies have shown a link between obesity and breast cancer, lipid metabolism is thought to play a role in the development of breast cancer (2,3). Fatty acid synthesis appears early in oncogenesis, expands as the cells become more malignant, promotes the transition from pre-and high-risk lesions to invasive cancer and may account for .90% of triglycerides (TGs) in tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Associations of Polymorphisms of rs693 and rs1042031 in Apolipoprotein B Gene With Risk of Breast Cancer in Chinese

Liu¹,

Wang²,

Qu³

et al. 2013

Japanese Journal of Clinical Oncology

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Background: Lipid synthesis is an integrated result of genetic, epigenetic and environmental factors, and also can promote growth and survival of cancer cells. Apolipoprotein B plays a central role in lipid metabolism as the major protein component of very-low-density lipoprotein and low-density lipoprotein. Methods: We investigated the associations of polymorphisms of rs693 (27673C.T) and rs1042031 (212669 G.A) in the APOB gene with risk of breast cancer in 675 bloodunrelated Chinese patients with breast cancer and 712 healthy controls. Results: Polymorphisms of 212669 G.A and 27673C.T in the APOB gene were significantly associated with an increased risk of breast cancer (P ¼ 0.000), especially for postmenopausal women (P ¼ 0.000, 0.023). The positive associations still remained after further analysis of the two polymorphisms' distribution according to body mass index. However, no statistical associations were found between 212669 G.A and 27673C.T polymorphisms and other clinical characteristics, including tumor size, lymph node metastasis, histological grade, estrogen and progesterone receptor status and Her-2 status. Conclusions: rs693 and rs1042031 polymorphisms in the APOB gene increased the risk of breast cancer in Chinese, and this role of the two polymorphisms in connection with breast cancer was not dependent on body mass index.

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Feasibility of a Lifestyle Intervention on Body Weight and Serum Biomarkers in Breast Cancer Survivors with Overweight and Obesity

Cited by 78 publications

References 38 publications

Is Quality of Life Related to Cardiorespiratory Fitness in Overweight and Obese Breast Cancer Survivors?

Is Quality of Life Related to Cardiorespiratory Fitness in Overweight and Obese Breast Cancer Survivors?

Effectiveness of an Internet Delivered Behavioral Weight Loss Intervention Provided to Breast Cancer Survivors

Associations of Polymorphisms of rs693 and rs1042031 in Apolipoprotein B Gene With Risk of Breast Cancer in Chinese

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