Associations of Polymorphisms of rs693 and rs1042031 in Apolipoprotein B Gene With Risk of Breast Cancer in Chinese

Abstract

Background: Lipid synthesis is an integrated result of genetic, epigenetic and environmental factors, and also can promote growth and survival of cancer cells. Apolipoprotein B plays a central role in lipid metabolism as the major protein component of very-low-density lipoprotein and low-density lipoprotein. Methods: We investigated the associations of polymorphisms of rs693 (27673C.T) and rs1042031 (212669 G.A) in the APOB gene with risk of breast cancer in 675 bloodunrelated Chinese patients with breast cancer and 712 healthy controls. Results: Polymorphisms of 212669 G.A and 27673C.T in the APOB gene were significantly associated with an increased risk of breast cancer (P ¼ 0.000), especially for postmenopausal women (P ¼ 0.000, 0.023). The positive associations still remained after further analysis of the two polymorphisms' distribution according to body mass index. However, no statistical associations were found between 212669 G.A and 27673C.T polymorphisms and other clinical characteristics, including tumor size, lymph node metastasis, histological grade, estrogen and progesterone receptor status and Her-2 status. Conclusions: rs693 and rs1042031 polymorphisms in the APOB gene increased the risk of breast cancer in Chinese, and this role of the two polymorphisms in connection with breast cancer was not dependent on body mass index.

Lipid Transporter Activity-Related Genetic Polymorphisms Are Associated With Steroid-Induced Osteonecrosis of the Femoral Head: An Updated Meta-Analysis Based on the GRADE Guidelines

“…In addition, rs1042031 is a coding sequence variant that causes glutamate to lysine mutation (C > T), or the introduction of a stop codon in the amino acid sequence (C > A). The rs1042031 mutation is important for regulating the binding of apolipoprotein B to the LDL cholesterol receptor (Liu et al, 2013). In this work, these two mutations were found to be related to SONFH.…”

Apolipoproteins, as the carrier proteins for lipids, are involved in the development of breast cancer

“…Both apolipoproteins are involved in lipid metabolism and cancer biology [1,71]. The investigation into the connections between apoB gene polymorphisms and BC risk reported by Liu et al concluded that polymorphisms, such as 12,669 GA and 7673 CT, significantly increase the risk of this tumor, particularly in women undergoing menopause [72]. Once breast carcinoma develops intraocular metastasis, apoB functions as a risk factor like apoA-I [65].…”

Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery

“…Though relative reports were not as many as apoAI, apoB is considered to have tumor-promoting effects. Liu et al found a correlation between polymorphisms of apoB gene and risk of breast cancer [ 21 ]. Cedó et al further found that apoB stimulated growth of estrogen receptor-positive breast cancer cells, via transporting 27-hydroxycholesterol [ 22 ].…”