Feasibility and safety of granulocyte colony-stimulating factor treatment in patients with acute myocardial infarction

Randomized Clinical Trials in Stem Cell Therapy for the Heart - Old and New Types of Cells for Cardiovascular Repair

“…Only three trials have reported positive results. In the FIRSTLINE-AMI trial (Ince et al, 2005), the RIGENERA study (Leone et al, 2007) and in the study by Takano et al (Takano et al, 2007), significant improvements in LVEF were observed. The rest of the trials showed negative findings.…”

Stem Cell Therapy in Myocardial Infarction Clinical Point of View and the Results of the REANIMA Study (REgenerAtion of Myocardium with boNe Marrow Mononuclear Cells in MyocArdial Infarction)

“…Several studies (Table 2) investigated the usage of granulocyte growth factor (G-CSF) for induction of longer and increased mobilization of stem cells during the first days of AMI (Valgimigli et al, 2008). The application of G-CSF for several days achieved the 10-30 times, increased of CD34+ cells number in peripheral blood (Ince et al, 2005;Valgimigli et al, 2005;Zohlnhöfer et al, 2006;Engelman et al, 2006;Ripa et al, 2006;Takano et al, 2007;Leone et al, 2007). When we analyzed the results of these studies it seemed that very early start of G-CSF after STEMI (during the first day) and its application in patients with lower LVEF (lower than 40%) had a positive effect on systolic function (Ince et al, 2005;Takano et al, 2007;Leone et al, 2007).…”

“…The application of G-CSF for several days achieved the 10-30 times, increased of CD34+ cells number in peripheral blood (Ince et al, 2005;Valgimigli et al, 2005;Zohlnhöfer et al, 2006;Engelman et al, 2006;Ripa et al, 2006;Takano et al, 2007;Leone et al, 2007). When we analyzed the results of these studies it seemed that very early start of G-CSF after STEMI (during the first day) and its application in patients with lower LVEF (lower than 40%) had a positive effect on systolic function (Ince et al, 2005;Takano et al, 2007;Leone et al, 2007). However, G-CSF had some potential prothrombotic and proinflammatory effects (Le Blanc et al, 1999;Falanga et al, 1999) which could be deleterious for patients with AMI, but it was not seen in the current published trials.…”

Granulocyte Colony Stimulating Factor in the Treatment of Cardiac Ischemic Disease. A Decade has Passed: Is it Time to Give Up?

“…1b). Initially, as requested, clinical investigations were performed with a limited number of patients, with or without a placebo group and in an openlabel or single-blind design [22][23][24][25][26][27]. All confirmed the safety and feasibility of G-CSF treatment.…”