Stem Cell Therapy in Myocardial Infarction Clinical Point of View and the Results of the REANIMA Study (REgenerAtion of Myocardium with boNe Marrow Mononuclear Cells in MyocArdial Infarction)

Obradović, Slobodan; Balint, Bela; Trifunović, Zoran

doi:10.5772/17700

Cited by 3 publications

(11 citation statements)

References 79 publications

(69 reference statements)

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“…Most studies were conducted in patients with acute MI and intracoronary application of BMMNC (about 30 randomized trials) and demonstrated conflicting results [21][22][23][24][25][26] . On the other hand, 12 studies reporting inconsistent results were performed in the patients with chronic ischemic cardiomyopathy, among them several with intramyocardial implantation concomitant to CABG 27,28 .…”

Section: Discussionmentioning

confidence: 99%

Functional recovery of patients with ischemic cardiomyopathy treated with coronary artery bypass surgery and concomitant intramyocardial bone marrow mononuclear cell implantation: A long term follow-up study

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Functional recovery of patients with ischemic cardiomyopathy treated with coronary artery bypass surgery and concomitant intramyocardial bone marrow mononuclear cell implantation: A long term follow-up study

et al. 2015

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“…Plastičnost MĆ je fenomen intersistemske ćelijske plastičnosti, koji odslikava široki fenotipski potencijal vrlo primitivnih MĆ, sposobnih za ukalemljenje u različita tkiva tokom implantacije autolognih MĆ na oštećeno mesto, uz sledstveno transdiferentovanje u ćelijske linije tkiva/organa domaćina i razvoj terapeutske mikroangiogeneze (neovaskularizacije) podstaknute faktorima angiogeneze [11][12][13][14][15][23][24][25].…”

Section: Grafting In Clinical Practiceunclassified

“…SC plasticity is a phenomenon of inter-systemic cell plasticity, which reflects the wide-ranging phenotypic potential of very primitive SCs, capable of homing to different tissues during the implantation of autologous SCs into the damaged area, with subsequent transdifferentiation into cell lineages of the host tissue/organ and the development of therapeutic micro-angiogenesis i.e., neovascularization stimulated by angiogenesis growth factors [11][12][13][14][15][23][24][25].…”

Section: Grafting In Clinical Practicementioning

confidence: 99%

“…Both identified classes of HSCs, short-term HSCs (ST-HSCs) and long-term HSCs (LT-HSCs), can reconstitute the blood of experimental animals for one to two months, and more than 6 months, respectively [2,5]. After homing, BM-derived SCs can undergo a multistep process involving migration, conversion to a new cellular phenotype, and expression of functions characteristic of the tissue where they reside [4,23,24].…”

Section: Adult Stem Cells -Concept and Functionalitymentioning

confidence: 99%

“…Slika 1 pokazuje da samo kombinacija nekoliko uslova može da posluži kao potvrda da su se neke MĆ, dobijene iz kostne srži, zaista transformisale u somatske ćelije (ćelije specifične za solidne organe) [2,4,[23][24][25].…”

Section: Pojam I Funkcionalnost Adultnih Matičnih ćElijaunclassified

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A stem cell overview: From evolving hemobiological concepts to (auto)grafting in clinical practice

Balint¹,

Pavlović²,

Marković³

et al. 2022

Srpski medicinski časopis Lekarske komore

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Conventional hematopoietic stem cell transplantation is a well-known treatment method for numerous acquired and congenital hematopoietic disorders, disorders of the immune system, as well as certain metabolic disorders. Stem cells (SCs) can be defined as cells capable of self-renewal with a high proliferative capacity and the potential to differentiate into functionally competent mature cells. Stem cells can be divided into embryonic SCs (ESCs) and tissue-specific or adult SCs - such as bone marrow (BM) stem cells, peripheral blood (PB) stem cells, and SCs derived from umbilical cord blood (UCB), as well as other non-hematopoietic or somatic SCs. SCs in adults are characteristically considered to be restricted in their regenerative and differentiative potential, while embryonic stem cells are 'true' totipotent/pluripotent cells, due to their ability to develop into endoderm, ectoderm, or mesoderm - all three embryonic tissue types in the human body. They are the most promising, but also the most controversial type of potentially transplantable SCs. Immature hematopoietic SCs have the potential of differentiating, not only into all blood cells, but also into some somatic cell types (SC plasticity). In different clinical settings, the transplantation of immature stem cells leads to the repopulation of recipient bone marrow, with subsequent complete, stable, and long-term reconstitution of hematopoiesis. Given that immature stem cells are also capable of homing to different tissues, autologous stem cell implantation into a damaged and/or ischemic area induces their colonizing and consecutive transdifferentiating into cell lineages of the host organ, including neovascularization. Thus, they are clinically applicable in the field of regenerative medicine for the treatment of myocardial, brain, vascular, liver, pancreatic, and other tissue damage. The purpose of this overview is to recapitulate the key developments in the rapidly evolving area of stem cell research, as well as to review the use of SCs in conventional transplantations and in regenerative medicine. Additionally, a brief critical evaluation of our own stem cell research will be summarized.

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Stem Cell-Based (Auto)Grafting: From Innovative Research Toward Clinical Use in Regenerative Medicine

Balint¹,

Obradović²,

Todorović³

et al. 2013

Stem Cell Biology in Normal Life and Diseases

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Stem Cell Therapy in Myocardial Infarction Clinical Point of View and the Results of the REANIMA Study (REgenerAtion of Myocardium with boNe Marrow Mononuclear Cells in MyocArdial Infarction)

Cited by 3 publications

References 79 publications

Functional recovery of patients with ischemic cardiomyopathy treated with coronary artery bypass surgery and concomitant intramyocardial bone marrow mononuclear cell implantation: A long term follow-up study

Functional recovery of patients with ischemic cardiomyopathy treated with coronary artery bypass surgery and concomitant intramyocardial bone marrow mononuclear cell implantation: A long term follow-up study

A stem cell overview: From evolving hemobiological concepts to (auto)grafting in clinical practice

Stem Cell-Based (Auto)Grafting: From Innovative Research Toward Clinical Use in Regenerative Medicine

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