Feasibility and Efficacy of Percutaneous Transcatheter Intraarterial Chemotherapy with Paclitaxel in Albumin Nanoparticles for Advanced Squamous-Cell Carcinoma of the Oral Cavity, Oropharynx, and Hypopharynx

Damascelli, B; Patelli, Gianluigi; Tichà, Vladimira; Tolla, Giuseppe Di; Frigerio, Laura; Garbagnati, F; Lanocita, Rodolfo; Marchianò, Alfonso; Spreafico, Carlo; Mattavelli, Franco; Bruno, Andrea; Zunino, Franco

doi:10.1016/j.jvir.2007.06.009

Cited by 34 publications

(17 citation statements)

References 27 publications

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“…It was expected that greater tumor exposure could be achieved through the use of macrocomplexes—liposomes and albumin nanoparticles—measuring 150–200 nm in diameter, because of the tumor’s substantial vascular network. In this setting, the so-called enhanced permeability and retention (EPR) effect occurs, whereby macrocomplexes pass through the discontinuous endothelium of tumor capillaries and maintain prolonged contact with the tumor cells because of the lack of effective lymphatic drainage toward the general circulation [9, 10]. This leads to high tumor exposure to the drugs with reduced systemic exposure.…”

Section: Discussionmentioning

confidence: 99%

Successful Intra-Arterial Chemotherapy for Extramammary Paget’s Disease of the Axilla in a Patient with Parkinson’s Disease

Damascelli

Tichà

2009

Cardiovasc Intervent Radiol

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Extramammary Paget’s disease (EMPD) is a rare intraepithelial neoplasm occurring less frequently in men and even more rarely in the axilla. A 59-year-old man with severe Parkinson’s disease presented with axillary EMPD. The neurological comorbidity made treatment of the EMPD problematical and prompted us to propose locoregional intra-arterial chemotherapy in single short sessions. Two innovative chemotherapeutic macrocomplexes were used: doxorubicin incorporated in large liposomes and the taxane paclitaxel incorporated in albumin nanoparticles. A therapeutic response was seen right from the first treatment and was macroscopically close to complete after four cycles. Five months after the end of treatment the patient had minimal visible disease and had enjoyed a distinct improvement in quality of life, with no noteworthy complications related to the intra-arterial chemotherapy with percutaneous transfemoral catheterization.

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Section: Discussionmentioning

confidence: 99%

Successful Intra-Arterial Chemotherapy for Extramammary Paget’s Disease of the Axilla in a Patient with Parkinson’s Disease

Damascelli

Tichà

2009

Cardiovasc Intervent Radiol

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“…Following this, 60 patients who suffered from stage T3/4 oral cancer participated in Phase II of the trial, where the positive effects were reaffirmed, providing an encouraging new approach for preliminary chemotherapy in tongue SCC. [105][106][107] Another Phase I trial investigated the use of NP albumin-bound paclitaxel (Abraxane) in designing a regimen combining cetuximab-loaded NPs with radiation therapy. A total of 25 patients with stage III-IVB HNSCC took the proposed treatment, and the researchers determined an optimum dose of NPs that could be further investigated and administered to patients already undergoing cetuximab and radiation therapy.…”

Section: Clinical Trialsmentioning

confidence: 99%

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Irimie

Sonea²,

Jurj

et al. 2017

IJN

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Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules. This review summarizes the main benefits of using these nanosystems, in parallel with a particular focus on the issues encountered in medical practice. These novel strategies have provided encouraging results in both in vitro and in vivo studies, but few have entered clinical trials. The use of nanosystems in oral cancer has the potential of becoming a valid therapeutic option for patients suffering from this malignancy, considering that clinical trials have already been completed and others are currently being developed.

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“…Several trials have demonstrated feasibility of this method for adjunctive tumor treatment, however survival benefit has not been demonstrated and catheter-related complications and long-term effects of neurotoxicity have not been clearly defined (Robbins and Homma, 2008; Robbins et al, 2010). Efforts in nanotechnology research have been explored, specifically using nanoparticle albumin-bound paclitaxel, to more safely deliver high concentrations of intra-arterial chemotherapy, however these agents remain investigational (Damascelli et al, 2007). Alternative methods of improved antineoplastic agent delivery have been explored in systemic administration including molecular targeting and gold nanoparticles as well as gene therapy, and these methods may be augmented with intra-arterial administration.…”

Section: Intra-arterial Chemotherapy For Head and Neck Tumorsmentioning

confidence: 99%

Endovascular Embolization of Head and Neck Tumors

Lazzaro¹,

Badruddin²,

Zaidat³

et al. 2011

Front. Neur.

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Endovascular tumor embolization as adjunctive therapy for head and neck cancers is evolving and has become an important part of the tools available for their treatment. Careful study of tumor vascular anatomy and adhering to general principles of intra-arterial therapy can prove this approach to be effective and safe. Various embolic materials are available and can be suited for a given tumor and its vascular supply. This article aims to summarize current methods and agents used in endovascular head and neck tumor embolization and discuss important angiographic and treatment characteristics of selected common head and neck tumors.

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Feasibility and Efficacy of Percutaneous Transcatheter Intraarterial Chemotherapy with Paclitaxel in Albumin Nanoparticles for Advanced Squamous-Cell Carcinoma of the Oral Cavity, Oropharynx, and Hypopharynx

Cited by 34 publications

References 27 publications

Successful Intra-Arterial Chemotherapy for Extramammary Paget’s Disease of the Axilla in a Patient with Parkinson’s Disease

Successful Intra-Arterial Chemotherapy for Extramammary Paget’s Disease of the Axilla in a Patient with Parkinson’s Disease

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Endovascular Embolization of Head and Neck Tumors

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