“…Antibacterial studies have also been performed against four bacterial strains B. subtilis, E. coli, P. aeruginosa, and S. typhi by using disc diffusion method, 4-NO 2 substituted pyranopyrazole with excellent zone of inhibition (16 mm). [1] The presence of catalyst [Fe 3 O 4 @CQD@Si(OEt) (CH 2 ) 3 NH@CC@Adenine@SO 3 H] + Cl À has produced (1) with 75-87 % [148] (Scheme 11). Interestingly, Some other catalysts such as nano-eggshell/Ti(IV), [149] orange peel-derived carbon-bearing sulfonic acid (OPC-SO 3 H), [150] Fe 3 O 4 @THAM-SO 3 H [151] , MIL-101(Cr)-N(CH 2 PO 3 H 2 ) 2 , [152] Fe 3 O 4 @SiO 2 @(CH 2 ) 3 NH@CC@ imidazole@SO 3 H, [153] Fe 3 O 4 @Cu-β-CD, [154] NiFe 2 O 4 , [155] Ltyrosine, [156] maltose, [157] molecular sieves, [158] morpholine triflate, [159] trichloroacetic acid, [44] thiamine hydrochloride, [160] Mn/ZrO 2 , [161] ZrO 2 NPs, [162] sodium benzoate, [50] silica-supported tetramethylguanidine, [163] uncapped SnO 2 quantum dots (QDs), [164] zirconium magnetic nanocomposite, [165] borax, [166] and magnetized water [8] have also been used to improve the yield of product.…”