Aqueous TPGS-750-M-mediated synthesis of pyrano[2,3-c]-pyrazoles: a sustainable and efficient approach

Abstract

The article describes a green and efficient synthesis method for pyrano[2,3-c]-pyrazoles, employing DL-alpha-tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) as a green and biodegradable surfactant in water. The utilization of water as a reaction medium and TPGS-750-M as a surfactant obviates the necessity for organic solvents, thereby enhancing the environmental sustainability of the synthesis. The compounds synthesized using this novel method was characterized using various spectroscopic techniques, including 1H-NMR, 13C-NMR, and mass spectrometry. Graphical abstract