Fe3O4@Au/reduced graphene oxide nanostructures: Combinatorial effects of radiotherapy and photothermal therapy on oral squamous carcinoma KB cell line

Multifunctional Theranostic Graphene Oxide Nanoflakes as MR Imaging Agents with Enhanced Photothermal and Radiosensitizing Properties

“…The overall steps for synthesis of GO-SPIO-Au are shown in Figure a. The morphology of GO-SPIO-Au was characterized by FE-SEM and TEM, as previously performed for elemental analysis . FE-SEM of GO (Figure b) and GO-SPIO-Au (Figure c) demonstrated a complex made of GO with the NPs visible as bright spots on the surface of GO flakes.…”

“…GO was prepared by oxidizing graphite flakes according to a modified Hummer’s protocol. , Briefly, 2 g of graphite flakes were mixed with 2 g of NaNO 3 and 82 mL of H 2 SO 4 for 20 min at 4 °C upon stirring. Then, 3 g of KMnO 4 was gradually added to the solution while stirring at 15 °C.…”

“…By applying both NIR and X-ray irradiation, these NFs are enabling substances for a combined PTT/RT strategy. By including SPIO NPs, the nanostructure can also be used as magnetic resonance (MR) imaging contrast agents. , In a preliminary in vitro study, we previously tested the beneficial effect of this nanostructure as a PTT and RT agent on nasopharyngeal cancer cells . In this study, we present a new modification for the synthesis of NFs to control the growth of AuNPs on GO sheets, and test the theranostic potential and cytotoxicity of the NFs on CT26 colorectal adenocarcinoma tumor cells in vitro and in vivo.…”

“…24,25 In a preliminary in vitro study, we previously tested the beneficial effect of this nanostructure as a PTT and RT agent on nasopharyngeal cancer cells. 26 In this study, we present a new modification for the synthesis of NFs to control the growth of AuNPs on GO sheets, and test the theranostic potential and cytotoxicity of the NFs on CT26 colorectal adenocarcinoma tumor cells in vitro and in vivo.…”

Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

“…The nanomedicine field had contributed significantly to improving the potency, lowering the toxicity margin of treatments in diseases like cancer (Hussein et al, 2012;Ibrahim et al, 2020). The applications may include increasing the precision of treatments such as radiotherapy and phototherapy (Ardakani et al, 2020;Meidanchi, 2020a;Meidanchi and Ansari, 2020;Meidanchi and Motamed, 2020). The use of nanoparticles with their unique properties may also help in overcoming the low solubility of hydrophobic agents like curcumin (Wang et al, 2013;Jafarzadeha et al, 2019).…”