Fe₃O₄@ZnO core-shell nanocomposites for efficient and repetitive removal of low density lipoprotein in plasma and on blood vessel

Abstract

Low density lipoprotein (LDL)-apheresis therapy, which directly removes LDL from plasma by LDL-adsorbents in vitro is found to be clinically effective and safe to lower the LDL content in blood to prevent cardiovascular disease. Thus, developing excellent LDL adsorbents are becoming more and more attractive. Herein, functional Fe3O4@ZnO core-shell nanocomposites have been synthesized by a facile and eco-friendly two-step method. Not only do they possess high LDL adsorption (in PBS/plasma as well as on blood vessels) and favorable magnetic targeting ability but they can also be reused conveniently, which offer the Fe3O4@ZnO core-shell nanocomposites significant potential in the removal of LDL in vitro and in vivo.

Biocompatible chitosan-modified core-shell Fe3O4 nanocomposites for exigent removal of blood lactic acid

“…And there was no hysteresis and their remanence as well as coercivity were zero, indicating Fe 3 O 4 @Chi NCs were superparamagnetic. In our previous studies, we showed that superparamagnetic nanoparticles performed well in magnetic guidance studies both in vitro [21][22][23] and in vivo [19]. Similarly, Fe 3 O 4 @Chi NCs could be conveniently gathered and guided by a magnet in a tubular structure( figure 1(d) insert) which not only showed good magnetic responses in vitro, but also revealed their potential application in a blood vessel.…”

“…To evaluate the hemocompatibility of Fe 3 O 4 @Chi NCs, hemolysis and thromboresistant experiments were carried out. The procedures were similar as described in our previous study [19]. Released hemoglobin was detected after co-incubation of different amounts of Fe 3 O 4 @Chi NCs with blood and hemolysis rates were calculated.…”

Multilayer Cucurbit[6]uril‐Based Magnetic Nanoparticles Prepared by Host–Guest Interaction: Remarkable Adsorbent for Low Density Lipoprotein Removal from Plasma

“…The adsorption mechanism might be as the followings. MNPs‐(HA‐DAH 5 /HA‐CB[6] 5 ) displayed negative charge characteristics, resulting in its strong adsorption performance for the positive charged apoB‐100 domain of LDL through electrostatic interactions . In addition, hydrogen bonding between LDL and HA in MNPs‐(HA‐DAH 5 /HA‐CB[6] 5 ) might contribute to the removal efficiency of LDL from plasma …”

P(BA-co-HBA) Coated Fe3O4@ZnO Nanoparticles as Photo-Responsive Multifunctional Drug Delivery Systems for Safer Cancer Therapy

“…Based on the proved property of ZnO shell that can transform from hydrophobic state to hydrophilic state under UV radiation and turn back to hydrophobic state under successive dark stay, 12 we checked the backbone under the driving force of hydrophobic/ hydrophilic conversion, which supplied a potential for DOC release and EGF adsorption. As expected, after UV radiation for 1 h, the amount of -OH on the surface of MDD decreased and at the same time, -CH 3 increased (Fig.…”