Fe₃O₄@SiO₂@Au nanoparticles for MRI-guided chemo/NIR photothermal therapy of cancer cells

Abstract

Novel functionalized nanoparticles, with toxicity controlled by laser irradiation, are perspective agents for potential (MRI)-guided stimulated chemo-photothermal treatment of cancer.

Nanoarchitectonics: Complexes and Conjugates of Platinum Drugs with Silicon Containing Nanocarriers. An Overview

“…Then the Fe 3 O 4 @SiO 2 system was made by reverse microemulsion method by constructing outer shell using TEOS and APTES and final decoration of the nanoparticles with 2-6 nm Au particles. Subsequently 16-mercaptohexadecanoic acid (MHDA) linker was applied to link with the NPs surface and immobilize cisplatin via COOH group (Figure 14) [52]. There are, however, weak proofs for actual chemical linking of cisplatin with -COOH moiety of MHDA.…”

“…The authors claim that the absorption band of C=O at 1680 cm −1 shows linking of cisplatin with NPs surface, but the absorption of free carboxyl group lies in exactly the same region of 1725 ± 65 cm −1 . So there seems to be a real possibility that cisplatin is simply entangled physically within MHDA (Figure 15) [52,53]. Raman spectra of: cisplatin (black spectrum), the pure MHDA (red spectrum), the Au NPs + MHDA (blue spectrum), Fe 3 O 4 @-SiO 2 @Au + MHDA + cisplatin (green spectrum).…”

“…Raman spectra of: cisplatin (black spectrum), the pure MHDA (red spectrum), the Au NPs + MHDA (blue spectrum), Fe 3 O 4 @-SiO 2 @Au + MHDA + cisplatin (green spectrum). There is a mistake in the figure as the value for C=O differs from the one in the text in both papers[52,53].…”

Simple synthesis of gold-decorated silica nanoparticles by in situ precipitation method with new plasmonic properties

“…Furthermore, the synthesis of gold nanoshells NPs with various dimensions and shapes presents us the possibility of obtaining metallic nanoshells with SPR band in the near-infrared ranges. These are of considerable interest by a wide range of possible applications in fluorescent sensors [2], biosensors [3], photothermal therapy [4,5], biomedical imaging [6], or drug carriers for cancer treatment [7]. The surface features directly affect its optical response which is key to these applications and especially in photothermal therapy which converts light into local heat (hyperthermia) that can kill cancer cells [8].…”

A Cost-Effective Nano-Sized Curcumin Delivery System with High Drug Loading Capacity Prepared via Flash Nanoprecipitation

“…Therefore, it is necessary not only to design novel drug delivery systems but also to propose efficient treatment strategies to improve the cure outcome. Polymeric nanoparticles (NPs) have been demonstrated as a promising opportunity to load hydrophobic anti-cancer drugs [ 9 , 10 , 11 , 12 , 13 ], in which amphiphilic polymers are commonly used as stabilizers to protect hydrophobic drugs through the intermolecular forces such as hydrogen bonding, hydrophobic, and electrostatic interactions, thus improving the solubility of hydrophobic drugs in aqueous solution and prolonging the internal circulation time [ 14 , 15 ].…”