Fe₃O₄@MoS₂/rGO Nanocomposite/Ionic Liquid Modified Carbon Paste Electrode for Electrochemical Sensing of Dasatinib in the Presence of Doxorubicin

Abstract

Cancer treatment by chemotherapy exploits one or more anticancer drugs to kill cancer cells. Because of the various side effects of chemotherapy drugs, sensitive determination of these drugs is one of the greatest challenges of adjuvant therapy. This study introduced the preparation of a selective and sensitive electrochemical sensor based on a carbon paste electrode (CPE) modified with Fe 3 O 4 @MoS 2 /reduced graphene oxide nanocomposite and ionic liquid (IL) (Fe 3 O 4 @MoS 2 /rGO/ILCPE) to determine dasatinib in the presence of doxorubicin. Results showed very good electrocatalytic activities of Fe 3 O 4 @MoS 2 /rGO/ILCPE toward the oxidation of dasatinib in phosphate buffer solution (PBS) (pH 7.0). The differential pulse voltammetry (DPV), chronoamperometry, and cyclic voltammetry (CV) were employed for studying the electrochemical behaviors of dasatinib on the modified electrode. Based on the optimal condition, we observed a linear increase of the voltammetric current by enhancing the dasatinib concentration in ranges between 0.02 μM and 390.0 μM. The detection limit for the dasatinib was equal to 6.0 nM, based on 3S b / m. Moreover, the modified CPE was used for the detection of dasatinib in the presence of doxorubicin. The corresponding electrochemical signals emerged as two well-resolved oxidation peaks with the considerable peak potential differences of 0.38 V. Finally, dasatinib and doxorubicin detection in the real samples were estimated by examining the functionality of our new sensor that showed acceptable recovery.

Novel Copper-Zinc-Manganese Ternary Metal Oxide Nanocomposite as Heterogeneous Catalyst for Glucose Sensor and Antibacterial Activity

“…Moreover, monitoring glucose is also highly important in pharmaceutical products where several food products are being used [ 6 ]. Until now, metal oxides (MOs) and metal sulfides (MSs) have been used as advanced electrocatalysts for developing highly sensitive electrochemical sensors [ 7 , 8 , 9 ]. However, these sensors have drawbacks such as low detection limits [ 10 , 11 , 12 ].…”

Simultaneous Determination of Doxorubicin and Dasatinib by using Screen-Printed Electrode/Ni–Fe Layered Double Hydroxide

“…According to our research, only a few articles have reported on the electrochemical measurement of DOX and DAS simultaneously. ,− Previous reported research showed that DAS and DOX are electroactive anticancer agents possessing high overvoltage potential, which could be detected via electrochemical sensors. − A poor oxidation signal and high overpotential make it difficult to determine the low levels of these anticancer agents. Accordingly, the modification of an electrode surface is essential to analyze the low concentrations of studied anticancer agents.…”

A New Electrochemical Sensor for the Detection of Ketoconazole Using Carbon Paste Electrode Modified with Sheaf-like Ce-BTC MOF Nanostructure and Ionic Liquid

“…There is a broad field of application of room temperature ionic liquids (RTILs) in analytical chemistry. RTILs are mixed with carbon substances to construct the conductive composites applied in electrochemical structures due to advantages such as a low vapor pressure, high conductivity, a wide electrochemical window, satisfactory chemical–thermal stability, and negligible toxicity [ 57 , 58 , 59 , 60 , 61 , 62 ].…”