Fe₃O₄@Astragalus Polysaccharide Core–Shell Nanoparticles for Iron Deficiency Anemia Therapy and Magnetic Resonance Imaging in Vivo

Abstract

Fe 3 O 4 @astragalus polysaccharide core-shell nanoparticles (Fe 3 O 4 @APS NPs) were demonstrated to be an efficient therapeutic drug for treating iron deficiency anemia (IDA) in vivo. The Fe 3 O 4 @APS NPs have been synthesized using a two steps approach involving hydrothermal synthesis and subsequent esterification. Transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy studies show that APS are attached on the surfaces of the highly monodisperse Fe 3 O 4 NPs. Dynamic light scatting (DLS) and magnetic characterizations reveal that the Fe 3 O 4 @APS NPs have outstanding water solubility and stability. Cytotoxicity assessment using Hela cells and pathological tests in mice demonstrate their good biocompatibility and low toxicity. The IDA treatment in rats shows that they have efficient therapeutic effect, which is contributed to both the iron element supplement from Fe 3 O 4 and the APS-stimulated hematopoietic cell generation. Moreover, the Fe 3 O 4 @APS NPs are superparamagnetic and thus able to be used for magnetic resonance imaging (MRI). This study has demonstrated the potential of nanocomposites involving purified natural products from Chinese herb medicine for biomedical applications. 3

Microalgal nanosized polyphosphate bodies as novel iron supplements for iron-deficiency anemia treatment in rats

“…(2) generally formed as Fe 3 O 4 in nanosized particles obtained from biomineralization (Alphandéry, 2020a; Rahn-Lee & Komeili, 2013). Synthesized nanoparticles (Fe 3 O 4 @APS NPs) have good water solubility and stability, especially in imitated digestion (Wang et al, 2019). In the present study, PPB also showed high water solubility and stability.…”

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications

“…Approved for coating are monosaccharides, which further improve biocompatibility and are successfully used intravenously for the treatment of iron deficiency [56,59]. Joined with iron sulfate, the lipid nanoparticle compritol 888 ATO initially behaves similar to a quick release drug and later displays sustained release.…”

Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects

“…Anemia is a worldwide public health problem that is caused by a range of factors, including inherited disease, acute blood loss, iron deficiency, end-stage renal disease, pregnancy and aging [ 1 ]. Iron-deficiency anemia (IDA) is a common nutritional disease suffered by 1 billion people and must be treated with iron formulations (such as ferrous sulphate, ferric carboxymaltose and Fe 3 O 4 @Astragalus polysaccharide nanoparticles) [ 2 , 3 , 4 ]. Though iron supplementation is an effective therapy, gastrointestinal disturbance and oxidative bowel damage are known to be uncompliant side effects.…”