2006
DOI: 10.1021/ja061323j
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Abstract: The Solomon-Bloembergen-Morgan theory predicts that the longitudinal relaxivity of a small Gd(III) complex, r 1p , increases upon slowing down its rotational correlation time. This is usually achieved by grafting the complex onto a macromolecule. Previous efforts in designing such macromolecules have concentrated on the synthesis of dendrimeric analogues and covalent or reversible protein conjugates. 2 These studies demonstrated the necessity not only of attaining fast water exchange but also of creating rigid… Show more

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Cited by 47 publications
(35 citation statements)
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References 16 publications
(19 reference statements)
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“…The relaxivities of HOPO-based systems have been further enhanced by slowing down of the rotational tumbling by incorporating them in Fe(III) templated assemblies [287], by coupling to MS2 virus capsids [288,289] and to dendrimers [290,291].…”
Section: Complexes Of Hydroxyhydropyridone (Hopo)-based Ligandsmentioning
confidence: 99%
“…The relaxivities of HOPO-based systems have been further enhanced by slowing down of the rotational tumbling by incorporating them in Fe(III) templated assemblies [287], by coupling to MS2 virus capsids [288,289] and to dendrimers [290,291].…”
Section: Complexes Of Hydroxyhydropyridone (Hopo)-based Ligandsmentioning
confidence: 99%
“…Controlling the spatial distribution of nanoparticles, both with respect to their placement as isolated particles or particle agglomerates of different sizes in a three dimensional framework and then placement of this framework in the infected tissue environment, is relevant, as an optimal arrangement can significantly increase the proton relaxivity value in two possible ways: (a) by generating very high magnetic field gradients from the collective magnetic behaviour of individual nanoparticles in the framework 14,15 and (b) by optimally trapping the water protons within the three dimensional framework, such that a significant increase in the interaction between the water protons and the superparamagnetic nanoparticles along with a reasonable proton exchange rate is achieved. 16,17 One possible way by which the "spatial distribution" factor can be employed is by using a bio-compatible, hydrophilic and flexible substrate, such as graphene oxide 18 as the framework material on which superparamagnetic nanoparticles can be organized in a controlled manner.…”
Section: Introductionmentioning
confidence: 99%
“…7 The further development of mixed 3,2-HOPO-TAM chelates follows the current trend of improving relaxometric properties of MRI-CA by formation of polymers 8 , dendrimers 9 or supramolecular compounds. 10 The feasibility of applying such 3,2-HOPO chelates as MRI-CA has been proven successfully in vivo.…”
mentioning
confidence: 99%