FDG-PET/CT in lymphoma

Abstract

Lymphomas are a heterogeneous group of diseases that arise from the constituent cells of the immune system or from their precursors. 18F-fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is now the cornerstone of staging procedures in the state-of-the-art management of Hodgkin's disease and aggressive non-Hodgkin's lymphoma. It plays an important role in staging, restaging, prognostication, planning appropriate treatment strategies, monitoring therapy, and detecting recurrence. However, its role in indolent lymphomas is still unclear and calls for further investigational trials. The protean PET/CT manifestations of lymphoma necessitate a familiarity with the spectrum of imaging findings to enable accurate diagnosis. A meticulous evaluation of PET/CT findings, an understanding of its role in the management of lymphomas, and knowledge of its limitations are mandatory for the optimal utilization of this technique.

Diagnostic imaging of hepatic lymphoma

“…However, it was also reported that if chemotherapy is initiated in an early stage in patients with a good physical status, the 3-year overall survival rate increases to 33% following successful treatment [9,49], which is approximately similar to that of the total 5-year overall DLBCL survival rate of 30-50%. [10] Therefore, the challenge is to diagnose the disease on the basis of symptoms, the levels of tumor markers such as sIL-2R, and imaging studies such as US, CT, and MRI, and to initiate chemotherapy in earlier stages [50,51].…”

Diagnostic accuracy of diffusion‐weighted imaging‐ magnetic resonance imaging compared to positron emission tomography/computed tomography in evaluating and assessing pathological response to treatment in adult patients with lymphoma: A systematic review

“…41 As referred to in Herrmann, 17,42 biopsy of all lesions for verifying the presence of lymphoma was considered unethical. PET/CT is highly accurate in the identification of lymphoma but the sensitivity and specificity are not 100%.…”

Minimally Invasive Diagnosis of Secondary Intracranial Lymphoma

“…It can also be effective, when used in conjunction with MRI, in identifying perineural spread [15], as in this case. PET CT also plays a major role in evaluating response to therapy [16] and its role in detecting relapse is well established [17]. …”