FCRL3 Gene Polymorphisms Confer Autoimmunity Risk for Allergic Rhinitis in a Chinese Han Population

Gu, Zheng; Hong, Suling; Xia, Ke; Shen, Yang; Wang, Xiaoqiang; Hu, Di; Hu, Guohua; Kang, Hou‐Yong

doi:10.1371/journal.pone.0116419

Cited by 13 publications

(11 citation statements)

References 34 publications

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“…4 ). These include cytokines (IL13, 100 101 IL4, 102 IL12B, 103 IL17A, 103 , 104 17F, 102 IL6, 105 IL27 106 ) cytokine receptors (IL23R, 107 IL12RB1, 108 and EBI3 109 ) immunity pathway molecules (JAK1, 110 FCRL3, 111 TNFSF4, 112 CTLA4, 113 CD14, 114 TNFA, 115 PBX2, 116 TAP1, 117 TNFAIP3, 118 FAM167A-BLK, 112 GATA3, 119 IRAK4, 120 RORA, 103 TGFB1, 121 and FOXP3 109 ), allergic airway inflammation and airway remodelling molecular genes (BDNF, 122 CYP2R1, 123 VDR, 123 ACE, 124 125 126 MRPL4, 115 ADAM33 127 128 ), and others (rs4982958 at 14q11.2). 129 Fig.…”

Section: Mechanismsmentioning

confidence: 99%

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Cheng

Chen

et al. 2018

Allergy Asthma Immunol Res

250

198

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Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.

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Section: Mechanismsmentioning

confidence: 99%

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Cheng

Chen

et al. 2018

Allergy Asthma Immunol Res

250

198

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“…These findings are consistent with earlier results, with emphasis on the association between −169 A/G polymorphism and autoimmune diseases . For instance, evidence were provided regarding a significant increase in the prevalence of the AA genotype and A allele of rs7528684 in allergic rhinitis (12). In another study, approximately 1.4-fold found significantly raised frequency of the FCRL3_3 C allele (OR=1.41 [95% CI=1.08–1.84], P =0.013) in women with endometriosis-related infertility (16).…”

Section: Discussionmentioning

confidence: 99%

Single Nucleotide Polymorphisms of FCRL3 in Iranian Patients with Behcet’s Disease

Shahram¹,

Kazemi²,

Mahmoudi³

et al. 2020

ijph

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Background: Both genetic and environmental factors influence, susceptibility to autoimmune disorders including Behcet’s disease (BD). FCRL3 (Fc receptor like 3 genes), a novel immunoregulatory gene, has recently been reported as a new promising candidate gene for general autoimmunity. This study was conducted to explore the potential association of FCRL3 polymorphisms with BD. Methods: This study was conducted from 2010 to 2015 in Tehran University of Medical Sciences, Tehran, Iran. Four single-nucleotide polymorphisms of FCRL3 (rs7528684, rs11264799, rs945635, and rs3761959) were genotyped in 220 patients and 220 healthy controls. Typing of the polymorphisms in this case-control study was carried out using polymerase chain reaction-restriction fragment length polymorphism analysis. Results: Analysis of the alleles revealed a significantly lower frequency of the A allele at the -169 site (rs7528684) in BD patients compared with that in controls (P=0.000, 66.4% versus 82%, χ2= 30.23). Moreover, a significant lower frequency of AA genotype and higher frequency of GG genotype was recorded for rs7528684. There was also relationship between posterior uveitis as a clinical sign of disease and polymorphism of allele A at the -169 site (P=0.015). Conclusion: This study revealed a significant difference in both allele and genotype frequency at position -169 of FCRL3 gene between Iranian patients with BD and normal subjects. These data suggest FCRL3 gene polymorphisms might be the autoimmunity risk factor for BD.

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“…Immunotherapy is used to treat AR, and immunotherapy of AR affects B-cell differentiation and decreases B-cell sensibility [42]. Autoimmunity risk of AR can be regulated by genes such as FCRL3 [43]. T-bet expressed in B cell is regarded as a transmitter of autoimmunity during antiviral responses in mammals [44].…”

Section: Discussionmentioning

confidence: 99%

Honeysuckle extract relieves ovalbumin-induced allergic rhinitis by inhibiting AR-induced inflammation and autoimmunity

Lin¹,

Cai²,

Wang

2019

Bioscience Reports

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Honeysuckle has antiviral, antioxidative and anti-inflammatory properties. Allergic rhinitis (AR) is induced by immunoglobulin E (IgE)-mediated inflammatory reaction. Our study investigates whether honeysuckle extract (HE) has therapeutic effect on AR. An AR model of mice was established by ovalbumin (OVA). Hematoxylin–Eosin staining was used to assess nasal mucosa damage. Enzyme-linked immunosorbent assay (ELISA) was performed to determine serum histamine, IgE and interleukin (IL)-2, IL-4, IL-17 and interferon-γ (IFN-γ) from nasal lavage fluid. Western blot was carried out to analyze the protein level from nasal mucosa tissue. We found that HE not only decreased nasal rubbing and sneezing in AR mice, but also reduced AR-induced damage to nasal mucosa. Moreover, HE lowered the levels of serum IgE and histamine and inhibited IL-4 and IL-17 levels from AR mice but raised IL-2 and IFN-γ levels in AR-induced nasal lavage fluid. Our results also showed that HE elevated the protein levels of forkhead box P3 (Foxp3) and T-box transcription factor (T-bet) in AR-induced nasal mucosa tissue, whereas it inhibited signal transducer and activator of transcription (STAT) 3 and GATA binding protein 3 (GATA-3) protein levels. By regulating AR-induced inflammatory reaction and autoimmune response, HE also relieved OVA-induced AR. Thus, HE could be used as a potential drug to treat AR.

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FCRL3 Gene Polymorphisms Confer Autoimmunity Risk for Allergic Rhinitis in a Chinese Han Population

Cited by 13 publications

References 34 publications

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Single Nucleotide Polymorphisms of FCRL3 in Iranian Patients with Behcet’s Disease

Honeysuckle extract relieves ovalbumin-induced allergic rhinitis by inhibiting AR-induced inflammation and autoimmunity

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