Favorable long-term outcome in adult genitourinary low-grade sarcoma

Froehner, Michael; Lossnitzer, A.; Manseck, Andreas; Koch, Rainer; Noack, Birgit; Wirth, Manfred P.

doi:10.1016/s0090-4295(00)00704-4

Cited by 31 publications

(16 citation statements)

References 17 publications

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“…Owing to the relative rarity of LMS-UB, the literature is comprised largely of case reports http://dx.doi.org/10.1016/j.urolonc.2014.01.025 1078-1439/r 2014 Elsevier Inc. All rights reserved. and small series [3,5,6,[8][9][10][11][12][13][14][15][16]. The largest series to date includes 36 cases [7].…”

Section: Introductionmentioning

confidence: 99%

Clinical features of leiomyosarcoma of the urinary bladder: Analysis of 183 cases

Rodríguez

Preston

Barrisford

et al. 2014

Urologic Oncology: Seminars and Original Investigations

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Section: Introductionmentioning

confidence: 99%

Clinical features of leiomyosarcoma of the urinary bladder: Analysis of 183 cases

Rodríguez

Preston

Barrisford

et al. 2014

Urologic Oncology: Seminars and Original Investigations

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“…Most patients when detected exhibit advanced pathologic stage, Fig. 1 Sonography and MRI of an adult urinary bladder leiomyosarcoma with fewer than 30% having stage T1 [19][20][21]. Indeed, in our patient group only 14% presented with clinical stage T1.…”

Section: Discussionmentioning

confidence: 59%

Urinary bladder leiomyosarcoma in adults

Labanaris

Zugor²,

Meyer

et al. 2007

Int Urol Nephrol

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Leiomyosarcomas of the bladder have always been considered as a highly aggressive entity and little is known about their origin, clinicopathologic presentation, and the survival factors associated with them. Contemporary studies suggest that these tumors may have a better prognosis than once believed. Leiomyosarcomas require aggressive surgical extirpation and, when surgical resection is possible, radical cystectomy with wide margins is the rule and should be performed. Strict adherence to standard surgical technique has resulted in low rates of positive surgical margins and low rates of local tumor recurrence.

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“…Only 2 late recurrences were reported (8 and 12 years after diagnosis, respectively [31,53]). The longest documented follow-ups of bladder leiomyosarcoma patients were 20 years after a radical cystectomy [22] and narrowly 22 years after a partial cystectomy ( [39], updated follow-up). Disease-specific cumulative mortality rate was 18% after 1 year, 38% after 5 years, and 50% after 10 years for all leiomyosarcoma patients ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The follow-up information of 2 patients seen in our clinic and published earlier [39] was updated. The following key questions were formulated prior to literature search in order to be answered with the data obtained by this review: (1) predisposing factors for the development of bladder leiomyosarcomas; (2) mean age of patients at the time of diagnosis; (3) proportion of primary surgical treatment; (4) sites and time of tumor recurrence; (5) 5-and 10-year cumulative mortality rates of highgrade versus low-grade tumors.…”

Section: Methodsmentioning

confidence: 99%

Leiomyosarcoma of the Urinary Bladder in Adult Patients: A Systematic Review of the Literature and Meta-Analysis

et al. 2018

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Purpose: Leiomyosarcoma of the urinary bladder is exceedingly rare. Most clinicians come across only a few cases during their career, and information regarding treatment and outcome is scattered in the scientific literature. Interested clinicians and patients have to undertake troublesome search for treatment and outcome information. Material and methods: We performed a systematic review of the literature using the PubMed and Web of Science databases and included all identified cases published in English language between 1970 and June 2018 into a meta-analysis. Prior to the literature search, key questions were formulated and with the data obtained, answers to these questions should be derived. Results: We analyzed clinical data of 210 cases of urinary bladder leiomyosarcoma revealed by this review and seen in our institution. The mean age of patients was 52 years. The majority (75%) of the tumors was classified as high-grade sarcomas. We found no report of a prior radiation therapy to the pelvic organs, but some authors suggested an association between cyclophosphamide treatment and the development of bladder leiomyosarcoma, especially in patients with retinoblastoma. For the whole sample, we determined 5- and 10-year cancer-specific cumulative mortality rates of 38 and 50%. Patients with high-grade sarcomas had a trend toward a higher mortality compared with low-grade tumors (p = 0.0280). The most promising treatment option seems to be surgery (radical or partial cystectomy) with negative resection margins, possibly supplemented by chemotherapy or radiation. Conclusion: About half of patients with bladder leiomyosarcoma survived on the long run. Low-grade tumors may have a better outcome with, nevertheless, countable long-term mortality. For better assessment of that rare bladder tumor, its best treatment options, and the influence of neoadjuvant or adjuvant therapies on the outcome of patients, a larger series with long-term survival data is required.

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Favorable long-term outcome in adult genitourinary low-grade sarcoma

Cited by 31 publications

References 17 publications

Clinical features of leiomyosarcoma of the urinary bladder: Analysis of 183 cases

Clinical features of leiomyosarcoma of the urinary bladder: Analysis of 183 cases

Urinary bladder leiomyosarcoma in adults

Leiomyosarcoma of the Urinary Bladder in Adult Patients: A Systematic Review of the Literature and Meta-Analysis

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