Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages

Abstract

Objectives: This study was to evaluate the effect of Palmijihwang-whan (PMJHW) aqueous extract in the regulation of hypothyroidism related reproductive organ damages in propylthiouracil (PTU)-induced rat model. Methods: PMJHW aqueous extract (yield=17.90%) were administered, once a day for 42 days from 2 weeks before start of PTU treatment as oral doses of 500, 250, and 125 mg/kg (body weight), and hypothyroidism was induced by daily subcutaneous treatment of PTU 10 mg/kg for 28 days. Results: PTU-induced hypothyroidism and related male reproductive organ damages-atrophic changes of testis, epididymis and prostate, were favorably and dose-dependently inhibited by treatment of PMJHW 500, 250, and 125 mg/kg. They also effectively regulated the PTU-induced abnormal antioxidant defense system changes in the testis. Although levothyroxine also favorably inhibited PTU-induced hypothyroidism, it deteriorated the hypothyroidism related male reproductive organ damages through testicular oxidative damages. The results suggest that oral administration of 125, 250, and 500 mg/kg of PMJHW has favorable effects on the hypothyroidism and related reproductive organ damages through augmentation of antioxidant defense system in the testis. Conclusions: This study suggest that PMJHW may be help to ameliorate the hypothyroidism and related organ damages in clinics.

Analysis of Research Trends in Papers Published in the Journal of Korean Medicine for Obesity Research: Focused on 2010-2019

“…(1) 동물연구(animal study) 54,55,57,58,61,62,65,66,69,72,73) , 당뇨유도모델을 활 용한 경우가 3편 60,64,68) 이었으며 이상지질혈증을 유도한 경 우는 2편 56,63) , 기타 질환을 유도한 경우는 5편 59,70,71,75,76) 이었 다. 비만관련 지표를 확인한 연구가 총 10편 54,55,57,58,61,62,65,66,69,73) 이었으며 지질대사와 관련한 연구가 6편 56,58,63,73,75,76) , 당대 사의 변화를 확인한 연구가 5편 [64][65][66]68,69) , 경구독성연구가 3편 55,67,74) , 호르몬 관련 연구가 2편 59,70) , 위장관 운동 관련 연구가 2편 60,68) 54,67,…”