Fatty Infiltration Does Not Progress After Rotator Cuff Repair in a Rabbit Model

Rubino, L. Joseph; Sprott, D.; Stills, Harold F.; Crosby, Lynn A.

doi:10.1016/j.arthro.2008.03.004

Cited by 36 publications

(33 citation statements)

References 13 publications

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“…Generally, it is considered that fatty infiltration is irreversible but that successful repair may halt its progression or partially reverse it. 9,11,19,28,29 Some authors have found that fatty infiltration of the supraspinatus and infraspinatus progresses despite healed repair. 8 Studies on the reversibility of muscle atrophy have also produced disparate results.…”

Section: Discussionmentioning

confidence: 98%

Changes in Appearance of Fatty Infiltration and Muscle Atrophy of Rotator Cuff Muscles on Magnetic Resonance Imaging After Rotator Cuff Repair: Establishing New Time-Zero Traits

Shin

2013

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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Section: Discussionmentioning

confidence: 98%

Changes in Appearance of Fatty Infiltration and Muscle Atrophy of Rotator Cuff Muscles on Magnetic Resonance Imaging After Rotator Cuff Repair: Establishing New Time-Zero Traits

Shin

2013

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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“…First, this is an animal study and translation of these findings to the human should be made with caution. The rabbit rotator cuff model is well accepted for investigation of pathologic conditions of muscle because it reproduces the key structural findings for muscle deterioration seen in humans and sheep after detachment of its tendon [29][30][31][32] . This study focused exclusively on the muscle tissue and did not investigate the tendon, primarily because …”

Section: Discussionmentioning

confidence: 99%

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Gerber

Meyer

Nuss

et al. 2011

Journal of Bone and Joint Surgery

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To our knowledge, this is the first documentation of partial prevention of important muscle alterations after retraction of the supraspinatus musculotendinous unit caused by tendon disruption. Nandrolone decanoate administration in the phase after tendon release prevented fatty infiltration of the supraspinatus muscle and reduced functional muscle impairment caused by myotendinous retraction in this rabbit rotator cuff model, but two of seven rabbits that received the drug developed infections. Background: Muscles of the rotator cuff undergo retraction, atrophy, and fatty infiltration after a chronic tear, and a rabbit

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“…8 However, rat studies limit translation to human, because rats are quadrupedal with weight bearing forelimbs; they have limited overhead and multidirectional shoulder movement, and they are small. 9,15 Larger animal models including the rabbit 8,19,20,36,37 , dog 9 , and sheep 14,49 share pathophysiological features of shoulder degeneration; however, the acromion and the coracoid process are small or not present, which differs from human shoulder anatomy. 8 …”

Section: Introductionmentioning

confidence: 99%

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates

Plate

Bates

Mannava

et al. 2013

Journal of Shoulder and Elbow Surgery

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Background Non-human primates have similar shoulder anatomy and physiology compared to humans and may represent a previously underutilized model for shoulder research. This study sought to identify naturally occurring bony and muscular degeneration in the shoulder of non-human primates and to assess relationships between structural and functional aspects of the shoulder and measures of physical function of the animals. We hypothesized that age-related degenerative changes in the shoulders of non-human primates would resemble those observed in aging humans. Methods Middle-aged (n=5, ages 9.4 to 11.8 years) and elderly (n=6, ages 19.8 to 26.4 years) female vervet monkeys were studied for changes in mobility and shoulder function, and radiographic and histologic signs of age-related degeneration. Results Four out of six (4/6) elderly animals had degenerative changes of the glenoid compared to 0/5 of the middle-aged animals (p=0.005). Elderly animals had glenoid retroversion, decreased joint space, walked slower and spent less time climbing and hanging than middle-aged vervets (p<0.05). Physical mobility and shoulder function correlated with glenoid version angle (p<0.05). Supraspinatus muscles of elderly animals were less dense (p=0.001), had decreased fiber cross-sectional area (p<0.001), but similar amounts of nuclear material (p=0.085). Degenerative rotator cuff tears were not observed in any of the eleven animals. Discussion and Conclusion The vervet monkey naturally undergoes age-related functional, radiographic and histological changes of the shoulder and may qualify as an animal model for selected translational research of shoulder osteoarthritis. Level of evidence Basic Science Study, in-vivo Animal Model

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Fatty Infiltration Does Not Progress After Rotator Cuff Repair in a Rabbit Model

Cited by 36 publications

References 13 publications

Changes in Appearance of Fatty Infiltration and Muscle Atrophy of Rotator Cuff Muscles on Magnetic Resonance Imaging After Rotator Cuff Repair: Establishing New Time-Zero Traits

Changes in Appearance of Fatty Infiltration and Muscle Atrophy of Rotator Cuff Muscles on Magnetic Resonance Imaging After Rotator Cuff Repair: Establishing New Time-Zero Traits

Anabolic Steroids Reduce Muscle Damage Caused by Rotator Cuff Tendon Release in an Experimental Study in Rabbits

Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates

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