Fatty change in the human temporomandibular joint disc. Light and electron microscopy study

Helmy, Emad S.; Timmis, David P.; Sharawy, Mohamed; Abdelatif, Osama; Bays, Robert A.

doi:10.1016/s0901-5027(05)80566-1

Cited by 15 publications

(7 citation statements)

References 15 publications

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“…Our histopathological findings in the disk proper following ADD, which included fatty degeneration, microcyst formation, hypercellularity, cartilage hyperplasia, ossification, cell clustering and fibrillation, were consistent with similar reports in human disks from patients with ADD (35)(36)(37). Fibrosis and hyalinization of the BZ which was reported in human ADD (38)(39)(40)(41)(42) is similar to our results.…”

Section: Discussionsupporting

confidence: 92%

Histopathological changes in rabbit craniomandibular joint associated with experimentally induced anterior disk displacement (ADD)

Ali

Sharawy

1994

J Oral Pathology Medicine

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Several studies have shown that anterior disk displacement (ADD) of human temporomandibular joint (TMJ) can lead to cellular and extracellular alterations in the disk proper, bilaminar zone (BZ), condyle, articular eminence and synovial membrane. Due to lack of an animal model for this disease, it is not known whether the mechanical displacement of the disk could lead to the observed histopathological changes. The purpose of this experiment was to investigate the histopathological changes that occur in the rabbit craniomandibular joint (CMJ) following surgical induction of ADD. The right CMJ was exposed surgically and the discal attachments were severed except for the BZ attachments. Then the disk was displaced anteriorly and sutured to the zygomatic arch. The left joint served as surgical control. The CMJs were removed after 24 h, 1 week, 2 weeks or 6 weeks and stained with H&E or modified Masson stain. The results showed neovascularization, cell clustering and fibrillation of the displaced disk. The BZ showed marked fibrosis. The condyle showed subchondral hemorrhage and fibrosis followed by osteoarthritic changes in the articular cartilage. The articular eminence showed chondrocytic clustering and an increase in the amount of chondroid bone. Synovial membrane exhibited marked hyperplasia. We concluded that surgical induction of ADD in the rabbit CMJ leads to cellular and extracellular alterations in the disk proper, BZ, condyle, articular eminence and synovial membrane similar to those described previously in human ADD. It appears that the mechanical trauma resulting from ADD could lead to a cascade of reparative and degenerative changes of the affected joints similar to those described for osteoarthritis.

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Section: Discussionsupporting

confidence: 92%

Histopathological changes in rabbit craniomandibular joint associated with experimentally induced anterior disk displacement (ADD)

Ali

Sharawy

1994

J Oral Pathology Medicine

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“…It is a consensus that TMJ disc displacement and OA often occur concomitantly. The most frequently reported relationship is that disc displacement causes OA (17,50,(52)(53)(54)(55)(56)(57)(58)(59)(60). With physiological loading, there is a balance between synthesis and breakdown within the tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Disc displacement is associated with degenerative tissue changes, and it is considered to be a risk factor for osteoarthrosis (OA) development with abnormal remodelling of the condyle and mandibular fossa; however, the underlying mechanisms remain unclear (11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

“…Under normal physiological conditions, a balance exists in synovial joints between tissue breakdown and repair. When the balance is disturbed by a biomechanical or inflammatory insult, the discal fibrocartilaginous remodelling system may fail, resulting in accelerated tissue breakdown . In TMJ diseases, the synovium and articular cartilage produce several mediators that have the potential to induce apoptosis .…”

Section: Introductionmentioning

confidence: 99%

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FasL expression in articular discs of human temporomandibular joint and association with osteoarthrosis

Camejo

Almeida

Doetzer

et al. 2013

J Oral Pathology Medicine

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“…Disc displacement is associated with degenerative tissue changes (8,9,11,(20)(21)(22)(23)(24)(25)(26), but the underlying mechanisms remain unclear. Although previous research has demonstrated a correlation between TMJ ID and apoptosis (27)(28)(29)(30), most studies have been done in animal models because of the difficulty in obtaining human material.…”

Section: Introductionmentioning

confidence: 99%

Apoptosis in displaced temporomandibular joint disc with and without reduction: an immunohistochemical study

Loreto

Almeida

Trevilatto

et al. 2011

Journal of Oral Pathology &Amp; Medicine

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Internal derangement (ID) of the temporomandibular joint (TMJ) is due to an abnormal relationship of the articular disc to the mandibular condyle, glenoid fossa and articular eminence. The two most common types of internal derangement are anterior disc displacement with (ADDwR) and without reduction (ADDwoR). Disc displacement is associated with degenerative tissue changes. The histological features of discs from patients with TMJ ID reflect a general remodelling caused by abnormal loading. A correlation has been demonstrated between TMJ ID and apoptosis. Few investigations have addressed the role of apoptosis or caspase activity in TMJ ID. The apoptosis activation process was studied in different areas of discs from 18 patients with ID (both ADDwR and ADDwoR) and four cadavers (controls), with emphasis on the expression of caspase 3, whose activation makes the death process irreversible. The results showed a greater proportion of caspase 3-positive cells in ADDwR and ADDwoR than in control discs. Immunopositivity also varied between disc areas; in particular, in ADDwoR sections labelled cells were significantly more numerous (P < 0.01) in the posterior disc attachment than in the anterior and intermediate bands. In addition, a significantly greater proportion of labelled cells was seen in the anterior (+) and intermediate (++) band of ADDwR compared with ADDwoR discs both bands (P < 0.05). These data suggest the importance of programmed cell death in the progression of TMJ ID.

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Fatty change in the human temporomandibular joint disc. Light and electron microscopy study

Cited by 15 publications

References 15 publications

Histopathological changes in rabbit craniomandibular joint associated with experimentally induced anterior disk displacement (ADD)

Histopathological changes in rabbit craniomandibular joint associated with experimentally induced anterior disk displacement (ADD)

FasL expression in articular discs of human temporomandibular joint and association with osteoarthrosis

Apoptosis in displaced temporomandibular joint disc with and without reduction: an immunohistochemical study

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