Fas<scp>L</scp> expression in articular discs of human temporomandibular joint and association with osteoarthrosis

Camejo, Flavio de Alcântara; Almeida, Luís Eduardo; Doetzer, Andrea Duarte; Caporal, Karina São Thiago; Ambros, Viviane; Azevedo, Marina Luise Viola de; Azevedo‐Alanis, Luciana Reis; Olandoski, Márcia; Noronha, Lúcia de; Trevilatto, Paula Cristina

doi:10.1111/jop.12089

Cited by 8 publications

(5 citation statements)

References 56 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the past few years, many papers have been published showing the participation of various markers and distinct pathways in the progression of TMJ ID using TMJ discs and synovial fluid (Kubota et al, 1998, De Alcantara Camejo et al, 2014, Loreto et al, 2013, Wake et al, 2013, Kim et al, 2012, Leonardi et al, 2010a, Vernal et al, 2008, Sato et al, 2003. Sato et al, in 2003, performed a study using also an immuno-histochemical technique for the examination of synovial tissue from 46 temporomandibular joints with internal derangement in 44 patients.…”

Section: Discussionmentioning

confidence: 99%

“…Since the inflammatory process influences the progression of ID, this study was designed to test the hypothesis that IL-6 may be more highly expressed in the TMJ disc in cases of ADDwR and ADDwoR, and not only in the synovial fluid, as already extensively described in the literature (De Alcantara Camejo et al, 2014, Loreto et al, 2013, Kim et al, 2012, Sato et al, 2003.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Camejo

Azevedo

Ambros

et al. 2017

Journal of Cranio-Maxillofacial Surgery

Self Cite

View full text Add to dashboard Cite

The inflammatory process is a coordinated response that protects host after infection or trauma, involving several molecular reactions. Once the inflammation is closely linked to the process of destruction of the temporomandibular joint, this study aims to examine, by immunohistochemistry, the expression of interleukin-6 (IL-6), an important inflammatory marker, in temporomandibular articular discs of patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR) and its association with osteoarthrosis (OA). Thirty-eight (n = 38) articular discs were divided into two cutoffs: 1) analysis 1: 4 control (acute pathology), 17 ADDwR, 17 ADDwoR; and 2) analysis 2: without OA (n = 21) and with OA (n = 17). The area of immunostaining was compared statistically between groups (p < 0.05). In the disc samples, no significant differences were observed between the groups ADDwR and ADDwoR, and with and without OA, in respect to the expression of IL-6 by immunohistochemical examination. Future studies should be conducted with a larger sample size, which could clarify the association of the inflammatory mediator IL-6 with temporomandibular joint dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Camejo

Azevedo

Ambros

et al. 2017

Journal of Cranio-Maxillofacial Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…Temporomandibular joint degenerative disease (TMJ-DD) is a condition that often occurs in women over 40 years of age and is associated with estrogen loss [23]. It has been proven that the fibrocartilage, which covers the articular surfaces, has estrogen receptors responsible for the normal trophism [24,25]. Women with endometriosis are often treated with hormonal therapy to put them into hypoestrogenism, the aim being to suppress their symptoms [26,27].…”

Section: Introductionmentioning

confidence: 99%

Endometriosis and the Temporomandibular Joint—Preliminary Observations

Wójcik

Goździewicz

Hudáková

et al. 2023

JCM

View full text Add to dashboard Cite

(1) Background: The complete picture of the disease is not fully recognized and extends far beyond the pelvis. The disease’s impacts lead to systemic inflammation, in turn resulting in sensitization to pain. The aim of this study was to check whether statistical correlations exist in women with endometriosis with regard to their experience of pain: headache, pelvic pain, temporomandibular joint pain, along with teeth clenching and the treatment of the disease. We constructed contingency tables, followed by Pearson’s chi-square test and Cramer’s V coefficient values. (2) Methods: A survey was conducted among 128 women aged 33.43 ± 5.79 with a diagnosis of endometriosis (disease duration 6.40 ± 5.88 years). (3) Results: There was a correlation between the occurrence of pain on the right and left sides of the pelvis and pain on the right and left sides of the temporomandibular joint, p-value = 0.0397, V = 0.2350, and between the presence of pelvic pain and the treatment of endometriosis, p-value = 0.0104, V = 0.3709, and between the presence of pain outside the pelvis and the treatment of endometriosis, p-value = 0.0311, V = 0.4549. There was a highly significant correlation between teeth clenching and temporomandibular joint pain, p-value = 0.0005, V = 0.3695. (4) Conclusions: The study revealed a correlation between pelvic endometriosis symptoms and symptoms in the temporomandibular joint.

show abstract

“…At this time, it has been speculated that the disc is damaged to varying degrees by excessive mechanical stress, in most cases, becomes deformed, or even perforated. In addition, disc displacement is associated with tissue degeneration, and it is considered to be a risk factor for the occurrence and development of osteoarthritis [4]. It has been shown that dynamic mechanical loading is a crucial stimulus to maintain the homeostasis of TMJ cartilage.…”

Section: Introductionmentioning

confidence: 99%

Anti-apoptotic effect of resveratrol: regulate of mitochondrial pathway in high tensile stress-induced goat temporomandibular joint disc cells

Ren

Bao

Muhamnad

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Attenuating of temporomandibular joint disc (TMJ disc) cells apoptosis may be an effective strategy to reduce abnormal stress-induced disc degeneration. However, a potential target to regulate the apoptosis of TMJ disc cells under abnormal stress is still inconclusive. Resveratrol (RSV) is a polyphenol with multiple effects such as anti-inflammatory, antioxidant, and anti-apoptosis. In this study, an appropriate periodic tensile stress was selected to induce apoptosis in goat TMJ disc cells. To examine the effect and mechanism of RSV on cells via apoptosis under high tensile stress. Results: An experimental model of high tensile stress-induced cells were successfully constructed with 8% stretching stimulus. CCK-8 and Flow cytometry assay showed that 8% tensile stress significantly promoted the apoptosis of TMJ disc cells. However, RSV (7.5μM) attenuated cell apoptosisunder high tensile stress, reflected by the increased ability of cell proliferation and decreased apoptosis rate. Furthermore, the gene expression of pro-apoptotic molecules (Bax and Caspase-3) was down-regulated, whereas that of anti-apoptotic molecule (Bcl-2) was up-regulated. It can be concluded that the mitochondrial pathway exerted an essential role in the regulation of apoptosis by RSV. Conclusion:High-intensity stress effectively promotes the apoptosis of goat TMJ disc cells, while RSV is able to reverse cell apoptosis through the mitochondrial pathway. This work provides a new reference for the clinical treatment of abnormal stress-induced TMJ disc degeneration.

show abstract

FasL expression in articular discs of human temporomandibular joint and association with osteoarthrosis

Cited by 8 publications

References 56 publications

Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Interleukin-6 expression in disc derangement of human temporomandibular joint and association with osteoarthrosis

Endometriosis and the Temporomandibular Joint—Preliminary Observations

Anti-apoptotic effect of resveratrol: regulate of mitochondrial pathway in high tensile stress-induced goat temporomandibular joint disc cells

Contact Info

Product

Resources

About