Fatty alcohol containing nanostructured lipid carrier (NLC) for progesterone oral delivery: In vitro and ex vivo studies

Elmowafy, Mohammed; Shalaby, Khaled; Badran, Mohamed M.; Ali, Hazim M.; Abdel-Bakky, Mohamed Sadek; El-Bagory, Ibrahim M.

doi:10.1016/j.jddst.2018.03.007

Cited by 14 publications

(7 citation statements)

References 29 publications

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“…Incorporation of combined fatty materials in lipid matrix also influenced the system pattern. Controlled release behavior of progesterone was observed by incorporation of fatty alcohol in lipid matrix of NLCs ( Elmowafy et al 2018a ). Specifically, chain length of saturated fatty alcohols particularly influenced econazole nitrate flux and permeability through porcine skin.…”

Section: Components and Formulation Attributesmentioning

confidence: 99%

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Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Elmowafy

Al‐Sanea

2021

Saudi Pharmaceutical Journal

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136

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NLCs have provoked the incessant impulsion for the development of safe and valuable drug delivery systems owing to their exceptional physicochemical and then biocompatible characteristics. Throughout the earlier period, a lot of studies recounting NLCs based formulations have been noticeably increased. They are binary system which contains both solid and liquid lipids aiming to produce less ordered lipidic core. Their constituents particularly influence the physicochemical properties and effectiveness of the final product. NLCs can be fabricated by different techniques which are classified according to consumed energy. More utilization NLCs is essential due to overcome barriers surrounded by the technological procedure of lipid-based nanocarriers’ formulation and increased information of the core mechanisms of their transport via various routes of administration. They can be used in different applications and by different routes such as oral, cutaneous, ocular and pulmonary. This review article seeks to present an overview on the existing situation of the art of NLCs for future clinics through exposition of their applications which shall foster their lucid use. The reported records evidently demonstrate the promise of NLCs for innovate therapeutic applications in the future.

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Section: Components and Formulation Attributesmentioning

confidence: 99%

“… Stearic acid Topical delivery of tretenoin ( Ghate et al 2016 ). Controlled release and acid protection of progesterone ( Elmowafy et al, 2018a ). Glyceryl monostearate Enhancement of oral bioavailability Omega-3 fatty acids ( Muchow et al 2009 ) and raloxifene ( Shah et al 2016 ).…”

Section: Components and Formulation Attributesmentioning

confidence: 99%

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Elmowafy

Al‐Sanea

2021

Saudi Pharmaceutical Journal

Self Cite

136

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“…They investigated the permeation across ex vivo rabbit duodenum and found enhanced permeation versus a suspension of progesterone, demonstrating the potential of this approach for enhancing oral delivery of progesterone. 112 An NLC formulation of nifedipine, combined with simvastatin (medication to treat elevated cholesterol), has been produced for potential treatment of cardiovascular disease.…”

Section: Lipid-based Nanomedicinesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions

et al. 2023

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“…Overall, cetyl alcohol showed better results in terms of release, uptake, stability and efficient duodenal permeation. Thus, NLCs are promising tool for the oral delivery of PG [47]. Delivery of drug through the oral route is highly preferred due to non-invasiveness, stability and high patient demand.…”

Section: The Panorama Of Novel Progesteronementioning

confidence: 99%

Nanonized progesterone formulation for improved oral bioavailability in healthy and pregnant rabbits

Jain¹,

Sharma²,

Modi³

et al. 2022

Journal of Pharmaceutical Negative Results

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The aim of this study is to evaluate and compare the oral bioavailability of nanonized progesterone (nano-PG) and micronized progesterone (micro-PG) sustained release tablet formulation in healthy and pregnant rabbits. High pressure compressed gas technology reduces the particle size from 1.72 ± 2.5 μm (micro-PG) to 800 ± 35 nm (nano-PG). DSC and XRD showed that both micro-PG and nano-PG were crystalline and exist as form I. Higher melting enthalpy of nano-PG indicated improved drug stability whereas XRD showed slight reduction in degree of crystallanity following nanonization. Nano-PG demonstrated 2-fold higher solubility in SDS aqueous solution and significantly higher permeability (p < 0.05) across porcine intestine compared to micro-PG. The pharmacokinetics of nano-PG and micro-PG was conducted in healthy and pregnant rabbits. The Cmax of nano-PG was higher in healthy and pregnant rabbits however the difference was significant in healthy rabbits only. The nano-PG demonstrated 30% and 18% higher bioavailability compared to micro-PG in healthy and pregnant rabbits, respectively. In conclusion, nanonization improves solubility, dissolution and bioavailability of PG in rabbits without affecting solid state characters.

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Fatty alcohol containing nanostructured lipid carrier (NLC) for progesterone oral delivery: In vitro and ex vivo studies

Cited by 14 publications

References 29 publications

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

Nanomedicine strategies to improve therapeutic agents for the prevention and treatment of preterm birth and future directions

Nanonized progesterone formulation for improved oral bioavailability in healthy and pregnant rabbits

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