Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro

Vučević, Dragana; Melliou, Eleni; Vasilijić, Saša; Gašić, Sonja; Ivanovski, Petar; Chinou, İoanna; Čolić, Miodrag

doi:10.1016/j.intimp.2007.05.005

Cited by 87 publications

(67 citation statements)

References 40 publications

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“…Second, in these preliminary investigations, we used limited but focused groups using one model organism to demonstrate feasibility. Our cell culture model was a contained system with one cell type, whereas an injury site would have multiple cell types, including inflammatory cells, with varying responses to fatty acids [17,19,45], as well as diffusion and metabolism of fatty acids. For this preliminary work, we aimed to identify basic cellular responses to C2DA and establish thresholds for potential clinical use.…”

Section: Discussionmentioning

confidence: 99%

Cis-2-decenoic Acid Inhibits S. aureus Growth and Biofilm In Vitro: A Pilot Study

Jennings

Courtney

Haggard

2012

Clinical Orthopaedics &Amp; Related Research

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Background Cis-2 decenoic acid (C2DA) disperses biofilm in many strains of microorganisms. However, whether C2DA inhibits bacterial growth or has potential to boost the actions of antibiotics is unknown. Questions/purposes We asked whether (1) C2DA inhibited MRSA growth and biofilm, (2) antibiotics increased inhibitory effects, (3) inhibitory concentrations of C2DA were cytotoxic to human cells, and (4) effective concentrations could be delivered from a chitosan sponge drug delivery device. Methods Broth containing seven concentrations of C2DA and six concentrations of either daptomycin, vancomycin, or linezolid was inoculated with a clinical isolate of MRSA and added to a total of 504 coated microtiter plate wells in triplicate (n = 3) for turbidity bacterial growth and crystal violet biofilm mass quantification. We used fibroblast cell viability assays of six C2DA concentrations (n = 4) to evaluate preliminary biocompatibility. We measured the elution of C2DA from a chitosan sponge drug delivery device with two representative loading concentrations (n = 3).

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Section: Discussionmentioning

confidence: 99%

Cis-2-decenoic Acid Inhibits S. aureus Growth and Biofilm In Vitro: A Pilot Study

Jennings

Courtney

Haggard

2012

Clinical Orthopaedics &Amp; Related Research

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“…Crenguta et al (2011) mentioned that RJ contains amino and gamma globulin, unsaturated fatty acids, hormones, enzymes, proteins, vitamin E and A that help the immune system fight infection. It has been recently shown that fatty acids isolated from RJ (10HDA and 3-10-dihydroxydecanoic acid) modulate the immune response in rat dendritic cell and T-cell cultures in different ways depending on concentration (they stimulate the proliferation of T cells, Vucevic et al, 2007). Moreover, AL-Mufarrej et al (1997) reported that chickens challenged with sheep erythrocytes (SRBC) significantly increased antibodies production when RJ was administered.…”

Section: Immunoglobulins Sheep Red Blood Cells (Antibody Titre) and mentioning

confidence: 99%

Impact of royal jelly to improve reproductive performance of male rabbits under hot summer conditions

El-Hanoun¹,

Elkomy²,

Fares³

et al. 2014

World rabbit sci.

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To alleviate the deleterious effect of heat stress during summer conditions on male rabbits' reproduction, 40 V Line adult rabbit bucks (on av. 8 mo old) were divided into 4 experimental groups and exposed to temperatures ranging from 23 to 36°C. Bucks in the 1 st , 2 nd , 3 rd , and 4 th group were supplemented with 0, 50, 100 or 150 mg of Chinese royal jelly (RJ)/kg twice per week, respectively, over a 20-wk period. Semen quality and blood biochemical constituents were evaluated. RJ at any dose exhibited a significant increase (P<0.05) in rabbits' sperm concentration, total sperm output, sperm motility, live sperm and normal sperm compared to the untreated controls. Plasma total protein, albumin, globulin, glucose and high density lipids (HDL) concentrations were significantly (P<0.05) boosted in the RJ groups compared to the controls. In contrast, RJ treatment resulted in a significant (P<0.05) reduction in plasma total lipids, triglycerides, cholesterol and low density lipids (LDL) concentrations. Treatment with RJ significantly boosted (P<0.05) testosterone concentration in the RJ groups to reach 110, 120 and 128%, respectively, of the control group. Improved kidney and liver functions were observed in the RJ bucks groups where plasma creatinine, urea concentrations, aspartate aminotransferase and alanine aminotransferase enzyme activities were significantly (P<0.05) decreased by RJ treatments. Treating bucks subjected to heat stress by different RJ doses increased (P<0.05) total antioxidant capacity to 106, 111 and 115% of basal, but significantly reduced (P<0.05) malondialdehyde and thiobarbituric acid reactive substances compared to the untreated. It was concluded that Chinese royal jelly supplementation for heat-stressed male rabbits can counteract summer infertility and improve their physiological status.

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“…So that, use of vaccine adjuvanted with some natural compounds may be useful for improvement of vaccine efficacy [27]. Substances such as Royal jelly with various immunomodulatory effects are good candidate for such purpose [28,29].…”

Section: Discussionmentioning

confidence: 99%

Adjuvant Effect of Royal Jelly on HIV-1 Multi-Epitope Vaccine Candidate: Induction of Th1 Cytokine Pattern

Mahdavi¹,

Cheragh²,

Bagheri³

et al. 2017

MOJI

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Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro

Cited by 87 publications

References 40 publications

Cis-2-decenoic Acid Inhibits S. aureus Growth and Biofilm In Vitro: A Pilot Study

Cis-2-decenoic Acid Inhibits S. aureus Growth and Biofilm In Vitro: A Pilot Study

Impact of royal jelly to improve reproductive performance of male rabbits under hot summer conditions

Adjuvant Effect of Royal Jelly on HIV-1 Multi-Epitope Vaccine Candidate: Induction of Th1 Cytokine Pattern

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