Fatty acids increase adiponectin secretion through both classical and exosome pathways

DeClercq, Vanessa; d’Eon, Brandon; McLeod, Roger S.

doi:10.1016/j.bbalip.2015.04.005

Cited by 42 publications

(35 citation statements)

References 72 publications

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“…The effect of EPA to increase adiponectin secretion from primary mature canine adipocytes is in agreement with more recent reports of increased adiponectin secretion from cultured human adipocytes (Tishinsky, Ma, & Robinson, ) as well as mouse adipocytes cell line 3T3‐L1 (DeClercq, d'Eon, & McLeod, ; Lefils‐Lacourtablaise et al, ; Oster, Tishinsky, Yuan, & Robinson, ; Prostek, Gajewska, Kamola, & Balasinska, ) in response to EPA or docosahexaenoic acid (DHA) treatment. However, earlier studies on the effect of EPA treatment on adiponectin gene expression and protein secretion reported contradictory results.…”

Section: Discussionsupporting

confidence: 89%

Dietary Fatty Acids Differentially Regulate Secretion of Adiponectin and Interleukin‐6 in Primary Canine Adipose Tissue Culture

Mazaki‐Tovi

Bolin

Schenck

2018

Lipids

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The aim of this study was to determine the effect of n3 polyunsaturated fatty acids (PUFA) on canine adipose tissue secretion of adiponectin, interleukin-6 (IL6), and tumor necrosis factor-α (TNFα). Subcutaneous and omental visceral adipose tissue samples were collected from 16 healthy intact female dogs. Concentrations of adiponectin were measured in mature adipocyte cultures, and concentrations of IL6 and TNFα were measured in undifferentiated stromovascular cell (SVC) cultures following treatment with eicosapentaenic acid (EPA, 20:5n-3), arachidonic acid (ARA, 20:4n-6), or palmitic acid (PAM, 16:0) at 25, 50, or 100 μM. Secretion of adiponectin from mature adipocytes was higher (p < 0.001) following EPA treatment at 50 μM compared to control in subcutaneous tissue, and higher following EPA treatment compared to PAM treatment at 25 μM in both subcutaneous (p < 0.001) and visceral tissues (p = 0.010). Secretion of IL6 from SVC derived from subcutaneous tissue was lower following EPA treatment and higher following PAM treatment compared to control both at 50 μM (p = 0.001 and p = 0.041, respectively) and 100 μM (p = 0.013 and p < 0.001, respectively). These findings of stimulation of adiponectin secretion and inhibition of IL6 secretion by EPA, and stimulation of IL6 secretion by PAM, are consistent with findings of increased circulating concentrations of adiponectin and decreased circulating concentration of IL6 in dogs supplemented with dietary fish oil, and show that the effect of fish oil on circulating concentrations of adiponectin and IL6 is, at least partially, the result of local effects of EPA and PAM on adipose tissue.

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Section: Discussionsupporting

confidence: 89%

Dietary Fatty Acids Differentially Regulate Secretion of Adiponectin and Interleukin‐6 in Primary Canine Adipose Tissue Culture

Mazaki‐Tovi

Bolin

Schenck

2018

Lipids

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“…[33][34][35] However, the secretory pathway of adiponectin is very complex, involving both the classical ER-Golgi pathway as well as unconventional secretory mechanisms such as an exosomemediated pathway. [36,37] One possible explanation for the salivary and cancer tissue adiponectin concentrations being elevated maybe due the presence adiponectin carrying exosomes. Adiponectin exists as a low-molecular-weight, middle-molecular-weight and high-molecular-weight forms in the circulation, with the middle-molecular-weight forms being the predominant form in the serum.…”

Section: Discussionmentioning

confidence: 99%

“…High-molecularweight forms are present principally in the exosome fraction. [36,37] The exosomes when shed by the breast cancer tissue circulate and attach to the cellular membrane of the recipient or target cell. In this case, salivary gland tissue which is histo-physiologically similar to mammary tissue.…”

Section: Discussionmentioning

confidence: 99%

“…[25] Hence, the exosomes serve as an intercellular messenger which stimulate adiponectin secretion into saliva. Taken together, this suggests that exosome-associated adiponectin [37] and exosome-free adiponectin may have different physiological and pathological functions in vivo and may elucidate the elevated adiponectin levels in salivary and cancer tissues as compared to the lower levels in serum. [26] If this explanation is correct, saliva may be a better media than serum for studying breast cancer progression as it reflects the true nature of neoplastic activity in a "real time" situation.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between salivary adiponectin, IGF-1, obesity and breast cancer

Streckfus¹

2017

JST

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Objective: The objective of this study was to determine if adiponectin and IGF-1 salivary concentrations are altered in combination with the presence of obesity and breast cancer. The null hypothesis is that there are no significant adiponectin and IGF-1 concentration alterations secondary to the presence of obesity and/or carcinoma of the breast.Methods: There were two groups of test subjects: healthy controls (n = 20) and individuals diagnosed with breast cancer (n = 20). The two cohorts were further stratified into four groups. These included subjects who are healthy and of normal BMI (n = 10); are healthy but have an elevated BMI (n = 10); have breast cancer and a normal BMI (n = 10); and have cancer and an elevated BMI (n = 10). The presence and concentration of adiponectin and IGF-1 was determined using the ELISA methodology.Results: The investigation revealed a significant increase in mean adiponectin levels in subjects with cancer compared to the controls (t = -2.57; p < .01). Individuals that were diagnosed with breast cancer and were obese exhibited the highest concentrations (F = 5.13; p < .005) of adiponectin. Adiponectin concentrations were also found to be correlated to IGF-I levels (r = 0.05; p < .001).Conclusion: Salivary adiponectin levels were significantly higher among cancer group. There were no significant differences between the cancer and control groups for IGF-I levels.

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“…It widely recognized that adipose tissue, in addition to being a primary storage of energy, plays a very important role in body metabolism primarily through adipocyte-macrophage interaction, releasing adiponectin, FA and the hormone leptin [80][81][82]. With only about 10% total systemic glucose uptake, adipose tissue may play only a minor quantitative role in postprandial glucose metabolism.…”

Section: Adipose Tissuementioning

confidence: 99%

Untitled

2017

Cent Asian J Med Sci

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Objectives:The fast-rising rate of diabetes incidents is a growing concern in Central Asian countries. This article reviews the current understanding of type 2 diabetes etiology, progression and treatment options along with opportunities for utilizing Avicenna's legacy in developing novel botanical therapeutics. Methods: Analysis of relevant publications, including a variety of Avicenna's work in Arabic, English and Russian. Results: With conventional treatment strategy shifting from single-component drugs aimed at one target to multitherapeutic combinations addressing the complex nature of many diseases and conditions, the role of multicomponent botanical preparations may increase. Diabetes mellitus is a serious chronic, progressive disease characterized by hyperglycemia, which is associated with a variety of comorbidities because of considerable damage, dysfunction and failure of multiple organs developed through the disease's progression. Multidisciplinary collaborative research that encompasses innovative tools could be used for effective development of new comprehensive therapeutic products and treatments based on knowledge of traditional medicine and supported by contemporary scientific validation. Conclusion: Comprehensive analysis of Avicenna's 1,000-year-old approach to the treatment of prediabetes and diabetes provides valuable directions in the search for plant-based treatments. Botanical therapeutics may provide relatively inexpensive and safe methods for diabetes treatment.

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Fatty acids increase adiponectin secretion through both classical and exosome pathways

Cited by 42 publications

References 72 publications

Dietary Fatty Acids Differentially Regulate Secretion of Adiponectin and Interleukin‐6 in Primary Canine Adipose Tissue Culture

Dietary Fatty Acids Differentially Regulate Secretion of Adiponectin and Interleukin‐6 in Primary Canine Adipose Tissue Culture

Relationship between salivary adiponectin, IGF-1, obesity and breast cancer

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