Fatty acids and related lipid mediators in the regulation of cutaneous inflammation

Kiezel-Tsugunova, Magdalena; Kendall, Alexandra C.; Nicolaou, Anna

doi:10.1042/bst20160469

Cited by 33 publications

(23 citation statements)

References 119 publications

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“…Sebum has the function of moisturizing the skin to prevent dryness 16 . And fatty acids in sebum can kill bacteria and protect the skin against mold and viruses 17 . In our study, age, gender, and unhealthy lifestyle have different effects on the sebum content of the forehead, but not on the dorsal hand.…”

Section: Discussionmentioning

confidence: 62%

Variation of biophysical parameters of the skin with age, gender, and lifestyles

Zhao

Wang

Mao

et al. 2020

J of Cosmetic Dermatology

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Background: Sweet, spicy or greasy food, staying up late, and using electronic products for a long time are common bad habits nowadays. Their role in skin diseases has been paid much attention. Objective: The aim of this study was to investigate whether unhealthy lifestyles would affect the skin sebum content, SC hydration, and pH and how do they affect. Methods: A total of 300 volunteers were enrolled, and a multifunctional skin physiology monitor measured the three skin biophysical properties on the forehead and dorsal hand. Lifestyle factors were evaluated by a self-administered questionnaire. Results: Eating oily, sweet, spicy food, and staying up late increased the sebum content of the forehead significantly. Dorsal hand SC hydration was higher in people eating more sweet food and oily food, and forehead SC hydration was higher in people eating more sweet food and go to bed earlier. Eating sweet food could increase pH in both forehead and dorsal hand. The forehead pH decreased in using electronic products over 6 hours a day or staying up late. There are significant differences in sebum, hydration, and pH value among different age groups. In males, the pH was lower than females, but the sebum was higher. Conclusion: Sebum content, SC hydration, and pH are affected by unhealthy lifestyles, age, and gender.

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Section: Discussionmentioning

confidence: 62%

Variation of biophysical parameters of the skin with age, gender, and lifestyles

Zhao

Wang

Mao

et al. 2020

J of Cosmetic Dermatology

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“…Recent developments in lipidomics technologies now allow in-depth qualitative and quantitative investigation of a wide variety of cutaneous lipids, providing insight into their roles and mechanistic actions [63]. Cross-communication between various types of bioactive lipids suggests that their cutaneous activities should be considered as part of a wider metabolic network that can be targeted to maintain skin health, control inflammation, and improve skin pathologies [64].…”

Section: Discussionmentioning

confidence: 99%

Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics

2018

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The skin represents one of the tissues that are most profoundly influenced by alterations in the quality of lipids (lipoquality). Lipids not only constitute cellular membranes, but also serve as bioactive lipid mediators and essential components of the skin barrier. Phospholipase A2 (PLA2) enzymes supply fatty acids and lysophospholipids from membrane phospholipids, thereby variably affecting cutaneous homeostasis. Accordingly, perturbation of particular PLA2-driven lipid pathways can be linked to various forms of skin disease. In this review article, we highlight the roles of several PLA2 subtypes in cutaneous pathophysiology, as revealed by transgenic/knockout studies in combination with comprehensive lipidomics. We focus mainly on secreted PLA2 group IIF (sPLA2-IIF), which is associated with epidermal hyperplasia through mobilization of a unique lipid metabolite. We also address the distinct roles of sPLA2-IIE in hair follicles and sPLA2-IID in lymphoid immune cells that secondarily affect cutaneous inflammation, and provide some insights into species differences in sPLA2s. Additionally, we briefly overview the patatin-like phospholipase PNPLA1, which belongs to the Ca2+-independent PLA2 (iPLA2) family, as a key regulator of skin barrier function through catalysis of a unique non-PLA2 reaction. These knowledges on lipid metabolism driven by various PLA2 subtypes will open novel opportunities for translated studies toward diagnosis and therapy of human skin diseases.

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“…During lipid extractions, protein pellets were retained for analysis using a standard Protein Assay Kit (Bio-Rad, Hercules, CA, USA). Proteins were solubilized using 1 M NaOH and analyzed within the linear range of the assay, as previously described ( 15 , 17 ).…”

Section: Methodsmentioning

confidence: 99%

Dynamics of the human skin mediator lipidome in response to dietary ω‐3 fatty acid supplementation

Kendall¹,

Pilkington

Murphy³

et al. 2019

The FASEB Journal

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Nutritional supplementation with fish oil or ω‐3 (n‐3) polyunsaturated fatty acids (PUFAs) has potential benefits for skin inflammation. Although the differential metabolism of the main n‐3PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) could lead to distinct activities, there are no clinical studies comparing their relative efficacy in human skin. Following a 10‐wk oral supplementation of healthy volunteers and using mass spectrometry‐based lipidomics, we found that n‐3PUFA mainly affected the epidermal mediator lipidome. EPA was more efficient than DHA in reducing production of arachidonic acid–derived lipids, and both n‐3PUFA lowered N‐acyl ethanolamines. In UV radiation–challenged skin (3 times the minimum erythemal dose), EPA attenuated the production of proinflammatory lipids, whereas DHA abrogated the migration of Langerhans cells, as assessed by immunohistochemistry. Interestingly, n‐3PUFA increased the infiltration of CD4+ and CD8+ T cells but did not alter the erythemal response, either the sunburn threshold or the resolution of erythema, as assessed by spectrophotometric hemoglobin index readings. As EPA and DHA differentially impact cutaneous inflammation through changes in the network of epidermal lipids and dendritic and infiltrating immune cells, they should be considered separately when designing interventions for cutaneous disease.—Kendall, A. C., Pilkington, S. M., Murphy, S. A., Del Carratore, F., Sunarwidhi, A. L., Kiezel‐Tsugunova, M., Urquhart, P., Watson, R. E. B., Breitling, R., Rhodes, L. E., Nicolaou, A. Dynamics of the human skin mediator lipidome in response to dietary ω‐3 fatty acid supplementation. FASEB J. 33, 13014–13027 (2019). http://www.fasebj.org

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Fatty acids and related lipid mediators in the regulation of cutaneous inflammation

Cited by 33 publications

References 119 publications

Variation of biophysical parameters of the skin with age, gender, and lifestyles

Variation of biophysical parameters of the skin with age, gender, and lifestyles

Phospholipase A2 in skin biology: new insights from gene-manipulated mice and lipidomics

Dynamics of the human skin mediator lipidome in response to dietary ω‐3 fatty acid supplementation

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