Fatty acid profiling as bioindicator of chemical stress in marine organisms: A review

Filimonova, Valentina; Gonçalves, Fernando; Marques, João Carlos; Troch, Marleen De; Gonçalves, Ana M.M.

doi:10.1016/j.ecolind.2016.03.044

Cited by 142 publications

(60 citation statements)

References 72 publications

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“…Fatty acids, specifically, can be used to detect chemical or toxic stress in marine organisms (Filimonova et al, 2016). Since, these animals did not appear to be starved, this suggest that nutrient depletion or toxin exposure may have been involved in the die-off of UCDs because (1) these were neonatal harbor seals (with a developing brain), (2) the coincident description of the necropsy reports, and (3) the fatty acid metabolic shifts in the brains of these animals.…”

Section: Discussionmentioning

confidence: 99%

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Brain transcriptomes of harbor seals demonstrate gene expression patterns of animals undergoing a metabolic disease and a viral infection

Rosales

Thurber

2016

PeerJ

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Diseases of marine mammals can be difficult to diagnose because of their life history and protected status. Stranded marine mammals have been a particularly useful resource to discover and comprehend the diseases that plague these top predators. Additionally, advancements in high-throughput sequencing (HTS) has contributed to the discovery of novel pathogens in marine mammals. In this study, we use a combination of HTS and stranded harbor seals (Phoca vitulina) to better understand a known and unknown brain disease. To do this, we used transcriptomics to evaluate brain tissues from seven neonatal harbor seals that expired from an unknown cause of death (UCD) and compared them to four neonatal harbor seals that had confirmed phocine herpesvirus (PhV-1) infections in the brain. Comparing the two disease states we found that UCD animals showed a significant abundance of fatty acid metabolic transcripts in their brain tissue, thus we speculate that a fatty acid metabolic dysregulation contributed to the death of these animals. Furthermore, we were able to describe the response of four young harbor seals with PhV-1 infections in the brain. PhV-1 infected animals showed a significant ability to mount an innate and adaptive immune response, especially to combat viral infections. Our data also suggests that PhV-1 can hijack host pathways for DNA packaging and exocytosis. This is the first study to use transcriptomics in marine mammals to understand host and viral interactions and assess the death of stranded marine mammals with an unknown disease. Furthermore, we show the value of applying transcriptomics on stranded marine mammals for disease characterization.

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Section: Discussionmentioning

confidence: 99%

“…As mentioned, fatty-acid markers have been used to detect stress responses in marine organisms (Trites & Donnelly, 2003; Filimonova et al, 2016). The transcripts detected in this study have the potential to be used as biomarkers for stranded animals with an elusive etiology or marine mammals that died from necrosis of the brain tissue.…”

Section: Discussionmentioning

confidence: 99%

Brain transcriptomes of harbor seals demonstrate gene expression patterns of animals undergoing a metabolic disease and a viral infection

Rosales

Thurber

2016

PeerJ

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“…There was also a substantial decrease in phospholipids, apparently in connection with membrane destruction [84][85][86]. Some papers have reported the modiications in lipid and faty acid composition of hydrobionts, including marine mussels, in response to organic and inorganic pollutants' efect [34,37,[87][88][89][90][91][92][93]. Since the lipid metabolism plays an important role in living organism, it is believed that the lipid and faty acid proile may be used to indicate the organism's health under stress conditions of pollutant efect.…”

Section: Pollution Efectmentioning

confidence: 99%

Lipid Composition Modifications in the Blue Mussels (Mytilus edulis L.) from the White Sea

Fokina¹,

Руоколайнен²,

Немова³

2017

Organismal and Molecular Malacology

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Studying biochemical indicators in response to various environmental factors allows revealing the metabolic adaptive strategy of the organism's tolerance and survival under a variety of environmental impacts. This review analyses both the authors' own data and the available literature on the problem of biochemical adaptations of the lipid composition in marine bivalves, particularly blue mussels, Mytilus edulis L., to various environmental impacts. Modiications in the composition of lipids and their faty acids in blue mussels caused by short-term (under laboratory conditions) and chronic (ield monitoring) exposure to natural and human factors indicate that homeostasis is maintained in cell membranes and the organism's energy requirements and facilitate the adaptation and tolerance of the mussels to environmental disturbances. The lipid and faty acid composition indices in White Sea intertidal mussels which relect their chronic exposure to a wide variety of environmental factors are discussed and compared to data on changes in the lipid composition of blue mussels exposed to some environmental factors (salinity, anoxia, metals) in aquarium experiments. The lipid proile plays an important role in the adaptation of blue mussels to new conditions in the habitat, and it can be used as a biochemical marker for indicating the organism's physiological state.

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“…As mentioned earlier, fatty-acid markers have been used to detect stress responses in 342 marine organisms (Trites & Donnelly, 2003;Filimonova et al, 2016). The transcripts detected in 343 this study have the potential to be used as biomarkers for stranded animals with an elusive 344 etiology or marine mammals that died from necrosis of the brain tissue.…”

mentioning

confidence: 84%

“…Fatty acids, specifically, can be used to detect chemical or toxic stress in marine 334 organisms (Filimonova et al, 2016). Since, these animals did not appear to be starved, this 335 suggest that nutrient depletion or toxin exposure may have been involved in the die-off of UCDs 336 because (1) these were neonatal harbor seals, (2) the coincident description of the necropsy 337 reports, and (3) the fatty acid metabolic shifts in the brains of these animals.…”

mentioning

confidence: 99%

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Supplemental Information 2: Significant Differentially Expressed Genes (DEGs, Padj ≪ 0.05) That Fell Within GO Category “Def

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Diseases of marine mammals can be difficult to diagnose because of the life history and protected status of these animals. Stranded marine mammals have been a particularly useful resource to discover and comprehend the diseases that plague these top predators.Additionally, advancements in high-throughput sequencing (HTS) has contributed to the discovery of novel pathogens in these animals. In this study, we use a combination of HTS and stranded harbor seals (Phoca vitulina) to better understand a known and unknown brain disease. To do this, we used transcriptomics to evaluate brain tissues from seven neonatal harbor seals that expired from an unknown cause of death (UCD) and compared them to four neonatal harbor seals that had confirmed phocine herpesvirus (PhV-1) infections in the brain. Comparing these two disease states we found that UCD animals showed a significant abundance of fatty acid metabolic transcripts in their brain tissue, thus we speculate that a fatty acid metabolic dysregulation contributed to the death of these animals. Furthermore, we were able to describe the response of four young harbor seals with PhV-1 infections in the brain. PhV-1 infected animals showed a significant ability to mount an innate and adaptive immune response, especially to combat viral infections.Our data also suggests that PhV-1 can hijack host pathways for DNA packaging and exocytosis. This is the first study to use transcriptomics in marine mammals to understand host and viral interactions and assess the death of stranded marine mammals with an unknown disease. Furthermore, we show the value of applying transcriptomics on stranded marine mammals for disease characterization. 14Diseases of marine mammals can be difficult to diagnose because of the life history and 15 protected status of these animals. Stranded marine mammals have been a particularly useful 16 resource to discover and comprehend the diseases that plague these top predators. Additionally, 17 advancements in high-throughput sequencing (HTS) has contributed to the discovery of novel 18 pathogens in these animals. In this study, we use a combination of HTS and stranded harbor seals 19 (Phoca vitulina) to better understand a known and unknown brain disease. To do this, we used 20 transcriptomics to evaluate brain tissues from seven neonatal harbor seals that expired from an 21 unknown cause of death (UCD) and compared them to four neonatal harbor seals that had 22 confirmed phocine herpesvirus (PhV-1) infections in the brain. Comparing these two disease 23 states we found that UCD animals showed a significant abundance of fatty acid metabolic 24 transcripts in their brain tissue, thus we speculate that a fatty acid metabolic dysregulation 25 contributed to the death of these animals. Furthermore, we were able to describe the response of 26 four young harbor seals with PhV-1 infections in the brain. PhV-1 infected animals showed a 27 significant ability to mount an innate and adaptive immune response, especially to combat viral 28 infections. Our data also sug...

show abstract

Fatty acid profiling as bioindicator of chemical stress in marine organisms: A review

Cited by 142 publications

References 72 publications

Brain transcriptomes of harbor seals demonstrate gene expression patterns of animals undergoing a metabolic disease and a viral infection

Brain transcriptomes of harbor seals demonstrate gene expression patterns of animals undergoing a metabolic disease and a viral infection

Lipid Composition Modifications in the Blue Mussels (Mytilus edulis L.) from the White Sea

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