Fatty acid composition of lipids in the maternal diet and establishment of a Lactobacillus sp. strain in the digestive tract of suckling gnotobiotic mice and rats

Abstract

Adult gnotobiotic mice and rats, monoassociated with a homofermentative strain of Lactobacillus sp. of intestinal origin, were fed either a commercial rodent chow A or a semisynthetic diet B. Similar numbers of lactobacilli were established in their gastrointestinal tract whatever diet they ate. The lactobacilli were established in the digestive tract of the newborn of A mothers at 2 days but were hardly established in mouse or rat pups of A mothers than in their mouse homologues. Comparative analysis of milk lipids in the A and B series showed a linoleic acid (18:2 n-6) content which was three times higher in the B than in the A series. Two diets S and H differing only by their lipid fractions, which, respectively, presented the same fatty acid compositions as lipids from diets A and B were then given to two others lots of Lactobacillus monoassociated mice. The establishment kinetics of the strain were the same in the mouse pups of these two lots precedently observed in the B series. The difference observed in the establishment kinetics of the Lactobacillus strain in the digestive tract of suckling gnotobiotic mice was thus attributed to other dietary factors than the fatty acid composition of the maternal diet.

Inhibitory effect of dietary soybean meal on the establishment of a Clostridium strain in the gastrointestinal tract of mice

“…The host's diet may be one of the factors which influence microbial populations in the gastrointestinal tract. Studies have shown that alterations in milk composition result in alterations of the microflora in animals (3,8,11) and in babies (1,13,18). Unfortunately, although various hypotheses have been made (2,5,9,10,13,14), the precise mechanisms by which diet influences the establishment of the gastrointestinal microflora are not known.…”