Fatty acid and cholesterol synthesis rates in the intact rat

Hutchens, T.T.; Bruggen, J.T. Van; West, Edward S.

doi:10.1016/0003-9861(54)90108-3

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…In all figures the total amount of acetate incorporated into the respective constituents of the whole organ is plotted against time. The curves thus obtained illustrate a rapid turnover of liver cholesterol and fatty acids in tumour-bearing animals, studied earlier in normal animals by Hevesy, Ruyssen and Beeckmans (1951), Beeckmans, Casier and Hevesy (1951), and Hutchens, van Bruggen and West (1954).…”

Section: E In Vivo Experimentssupporting

confidence: 61%

The Metabolism of Neoplastic Tissues: Synthesis of Cholesterol and Fatty Acids from Acetate by Transplanted Mouse Tumours in vitro and in vivo

Emmelot¹,

Bosch²

1955

Br J Cancer

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Section: E In Vivo Experimentssupporting

confidence: 61%

The Metabolism of Neoplastic Tissues: Synthesis of Cholesterol and Fatty Acids from Acetate by Transplanted Mouse Tumours in vitro and in vivo

Emmelot¹,

Bosch²

1955

Br J Cancer

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“…Furthermore, Frantz and Hinkelman (19) have cited findings obtained by others as well as themselves concerning the normal rate of synthesis of cholesterol by the rat which show this rate to be too low to account for the cholesterol rise in the blood after Triton administration. Other workers such as Hutchens, Van Bruggen, and West (20) and Landon and Greenberg (18) may be cited who found by similar technics more rapid normal rates of "synthesis" which are adequate to account for the blood cholesterol rise after Triton without the necessity of postulating large increases in synthesis rate. It also should be pointed out that there is agreement between the findings obtained in our laboratory (10) and that of Frantz and Hinkelman (19) concerning the quantitative amounts of cholesterol in plasma and liver before and after administration of Triton to rats.…”

Section: Resultsmentioning

confidence: 97%

The Effect of Certain Chelating Substances (Edta) Upon Cholesterol Metabolism in the Rat 1

Rosenman¹,

Smith²

1956

J. Clin. Invest.

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There is increasing use in biology and medicine of certain salts of ethylenediamine tetraacetic acid (EDTA), substances which can form stable complexes with multivalent positive ions. Certain such chelating agents have been reported (1-3) to affect cholesterol metabolism. It therefore was believed of interest to study the nature of these possible effects.I. Another series of 32 rats (II) was divided into four groups which were fed stock laboratory ration to which was added powdered cholesterol (2 per cent of diet) and cholic acid (1 per cent of diet), previously shown to induce chronic hypercholesteremia in rats (4,5). Eight control rats ingested only this ration. The disodium salt of EDTA (4 per cent of diet) was added to the ration of 8 rats, tetrasodium EDTA (4 per cent of diet) to that of 8 other rats, and disodium calcium EDTA (4 per cent of diet) to the ration of the remaining 8 rats.A third series of 30 rats (III) was fed stock ration with a larger amount of added powdered cholesterol (4 per cent of diet) and cholic acid (1 per cent of diet). The rats were divided into four groups. The basic ration was fed to 6 control rats while 8 rats in each of the three other groups ingested the same ration containing added salts of EDTA as in the preceding series of rats.The daily food consumption of all rats was measured for 7 days. The rats of the first two series were bled after 14 days and those of the third series after 21 days. In each instance the plasma cholesterol was determined on an alcohol-acetone extract according to the method of Zlatkis, Zak, and Boyle (6).1 Aided by Grants from the American Heart Association and the San Francisco Heart Association. 2 We wish to express our appreciation to Dr. Joseph A. Morrell of the R. J. Strasenburgh Company for supplying the EDTA salts used in this investigation. RESULTSIn Table I it can be seen that most rats ingesting diets with EDTA supplements exhibited moderate loss of weight. This could not be ascribed to diminished food intake since these rats each ingested from 16 to 21 grams of food per day, an amount essentially the same as that ingested by the control animals.The ingestion of ration supplemented with cholesterol and cholic acid, as previously noted (4, 5), induced progressive chronic hypercholesteremia in the rats of Series II and III. As shown in Table I the magnitude of this hypercholesteremia was increased by the addition to the diet of each of the salts of EDTA, but was greatest in the animals fed disodium EDTA. In contrast, the rats ingesting ration containing disodium EDTA without added cholesterol or cholic acid (Series I) failed to exhibit any rise of plasma cholesterol. II. The Effect of Injected Disodium EDTA onPlasma Cholesterol of Rats Fed Excess Cholesterol The following experiment was performed in order to determine if the above augmenting effect of ingested EDTA on the plasma cholesterol of rats fed excess cholesterol also occurred whew EDTA was given parenterally and when cho)fc acid was omitted from th ration. MethodsA series of 24 ftts ...

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Biochemistry of Sphingosine Containing Lipids

Burton¹

1967

Lipids and Lipidoses

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Fatty acid and cholesterol synthesis rates in the intact rat

Cited by 10 publications

References 16 publications

The Metabolism of Neoplastic Tissues: Synthesis of Cholesterol and Fatty Acids from Acetate by Transplanted Mouse Tumours in vitro and in vivo

The Metabolism of Neoplastic Tissues: Synthesis of Cholesterol and Fatty Acids from Acetate by Transplanted Mouse Tumours in vitro and in vivo

The Effect of Certain Chelating Substances (Edta) Upon Cholesterol Metabolism in the Rat 1

Biochemistry of Sphingosine Containing Lipids

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