Fatores de virulência de Candida spp isoladas de cateteres venosos e mãos de servidores hospitalares

Abstract

Revista da Sociedade Brasileira de Medicina

Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

“…among the workers was 15.7%, an average that is below the result previously verified by other studies 52,53 . However, except for C. lusitaneae, which was not isolated from any patient in this research, the remaining isolates of Candida non-albicans from the environment and the hands of the hospital staff members were also isolated from the patients.…”

“…On the other hand, 85.7% of the C. albicans samples isolated from patients were positive for phospholipase activity, whereas only 16.7% of the Candida non-albicans revealed phospholipase positivity, suggesting that this enzyme and C. albicans might be associated but are independent of virulence, as confirmed by other works that attest to the predominant production of phospholipase among C. albicans isolates from both healthy individuals and pathogenic cases, proving that phospholipase synthesis is not restricted to pathogenic samples 24,28,36,46,52,58 . Such fact also implies that phospholipase is not a determinant factor of the disease settlement, once the host immunity, the endogenous presence of C. albicans, and the effectiveness of the pathogenicity in the samples are also considered.…”

“…With reference to health practitioners, some researches inform that C. albicans is the most commonly isolated species from the hands of the healthcare staff 51,52 , while some authors have identified C. tropicalis and C. parapsilosis as dominant species 2,12,24,50,51 . In this work, C. albicans was isolated only once from the hand of a healthcare assistant; it was never isolated from the room air.…”

“…The occurrence of nosocomial infections by invasive candidiasis at the Universitary Hospital of the Jundiaí Medical College during the period covered by this research was of 4% above the average described by national and international references, which report an occurrence rate of 1.49 to 6.6 cases in 1,000 hospital admissions [22][23][24][25][26] . The hospital sector where cases of candidemia are most commonly found is the ICU, for besides being the place where patients find themselves more impaired, it also completes a routine of invasive procedures, probes, and long-term catheters 19,[27][28][29] . All the candidemia cases in this study were observed in patients in ICUs, a point that is also discussed by other studies that recognize the ICU as a place of utmost susceptibility to the incidence of such infection [30][31][32][33] .…”

Avaliação Da Associação Da Terapia Fotodinâmica Com Azul De Metileno Ao Óleo Safeteam® Sobre Cepas De Candida Albicans Isoladas De Cateter

“…As espécies de Candida estão entre a terceira e a quarta principal causa de infecção da corrente sanguínea (TAMURA et al, 2007;KHOURI, 2010) e estão presentes na microbiota normal da pele, boca, trato digestivo e vagina. Devido à sua natureza oportunista e quando associada a fatores de predisposição, possuem a capacidade de invadir tecidos e se aderirem a materiais artificiais, tais como sondas, cateteres de látex, entre outros materiais.…”