Fatores de risco para óbito por COVID-19 no Acre, 2020: coorte retrospectiva

Prado, Patrícia Rezende do; Gimenes, Fernanda Raphael Escobar; Lima, Marcos Venícius Malveira de; Prado, Virgilio; Soares, Carolina Pontes; Amaral, Thatiana Lameira Maciel

doi:10.1590/s1679-49742021000300018

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…A idade média foi de 65 anos. Notou-se também amplitude elevada entre o valor de mínimo e de máximo, constatado pelo coeficiente de variação (18,92), sendo o mais jovem de 28 e o mais idoso de 82 anos.…”

Section: Resultsunclassified

“…Números muito parecidos foram relatados por outros autores. 12,14,15,31 Estudos recentes 16,17,18 evidenciaram, também, que os principais fatores de riscos que podem propiciar quadros severos da COVID-19, e que podem refletir em índices mais elevados de mortes, estão atrelados ao avanço da idade. 2021) revelaram que a posição prona auxilia a melhora do edema pulmonar, tendo como referência desfecho desfavorável de 16% dos pacientes contra 32% dos que não a realizaram.…”

Section: Resultsunclassified

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SARS-CoV-2 letal: predomínios e lapsos temporais

2022

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Introdução: Em 2019, identificou-se o coronavírus-2 da síndrome respiratória aguda grave (SARS-CoV-2) que causa a Doença do Coronavírus-19 (COVID19), o qual proliferou-se gerando uma pandemia. A mortalidade relaciona-se com a pneumonia viral associada à síndrome respiratória aguda grave (SRAG), mas paira a dúvida sobre as características predominantes e seus lapsos temporais no decurso dos casos letais. Objetivos: Identificar características epidemiológicas, clínicas, laboratoriais e tomográficas predominantes, correlacionar as alterações inflamatórias, determinar a proporção da execução da posição prona e da utilização de bloqueador neuromuscular e identificar os lapsos temporais de decurso e ventilação mecânica da SARS-CoV-2 letal. Método: Estudo observacional, retrospectivo e analítico de 44 prontuário de pacientes com SARS-CoV-2 letal no Hospital Universitário Evangélico Mackenzie entre março e setembro de 2020. Resultados: Predominânica do sexo masculino (66%), acima de 60 anos (70,46%) com alterações da PCR (90,91%), linfócitos (63,64%), creatinina (54,55%) e PaO2/FiO2 (86,36%) com médias respectivas de 13mg/L, 1155, 1,6mg/dl e 169,91. Correlações: PCR/linfócito (-0,43), PCR/leucócitos (0,31) e Leucócitos/linfócitos (-0,35). Imagens tomográficas com vidro fosco bilateral (84,09%), hipertensão arterial com outras comorbidades (52,27%), posição prona (64%) e bloqueador neuromuscular (84%). A mediana do decurso hospitalar de 19 dias com 10 dias de ventilação mecânica. Conclusão: Identificou-se na SARS-Cov-2 letal a predominância de idosos do sexo masculino com hipertensão arterial associada a outras comorbidades, que evoluíram com disfunção renal, inflamação sistêmica correlacionada com linfopenia, SDRA moderada e vidro fosco bilateral, que necessitaram posicionamento prona e bloqueadores neuromusculares com lapsos temporais de 19 dias de decurso hospitalar mediano e 10 dias de ventilação mecânica. Palavras-chave: Insuficiência Respiratória; Infecções por SARS-CoV-2; Respiração Artificial.

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Section: Resultsunclassified

SARS-CoV-2 letal: predomínios e lapsos temporais

2022

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“…Identifying these factors is essential for scaling up preventive measures and clinical management of covid-19 worldwide, as well as supporting government strategies to respond to the pandemic. 9 ),( 10 …”

Section: Introductionmentioning

confidence: 99%

Factors associated with covid-19 deaths in the city of Recife, Pernambuco, Brazil, 2020: a cross-sectional study with “Notifique Aqui” system data

Souza

Holanda

Barros

2023

Epidemiol. Serv. Saúde

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Objective: to analyze the clinical conditions and sociodemographic characteristics associated with covid-19 deaths in the first year of the pandemic in the city of Recife, Pernambuco, Brazil, 2020. Methods: this was a cross-sectional study with covid-19-induced severe acute respiratory syndrome cases recorded in 2020 via the “Notifique Aqui” (Report Here) electronic system of the Pernambuco Center for Strategic Information on Health Surveillance. Association between death and sociodemographic and clinical variables was analyzed. Prevalence ratios (PR) with 95% confidence intervals (95%CI) were calculated using adjusted Poisson regression. Results: the prevalence of death was 28.4% (2,833 cases; 95%CI 27.51;29.28). The associated factors were male sex (PR = 1.05; 95%CI 1.01;1.08), age ≥ 60 years (PR = 0.76; 95%CI 0.72;0.79), dyspnea (PR = 1.06; 95%CI 1.02;1.10), respiratory distress (PR = 1.06; 95%CI 1.03;1.09), oxygen saturation < 95% (PR = 1.08; 95%CI 1.04;1.11) and chronic diseases. Conclusion: covid-19 deaths were more prevalent among male, older adults, and people with pre-existing health problems, these being priority groups for combating the pandemic.

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Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies

Makovski,

Ghattas,

Monnier-Besnard

et al. 2024

Aging Clin Exp Res

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Background Estimating the risks and impacts of COVID-19 for different health groups at the population level is essential for orienting public health measures. Adopting a population-based approach, we conducted a systematic review to explore: (1) the etiological role of multimorbidity and frailty in developing SARS-CoV-2 infection and COVID-19-related short-term outcomes; and (2) the prognostic role of multimorbidity and frailty in developing short- and long-term outcomes. This review presents the state of the evidence in the early years of the pandemic. It was conducted within the European Union Horizon 2020 program (No: 101018317); Prospero registration: CRD42021249444. Methods PubMed, Embase, World Health Organisation COVID-19 Global literature on coronavirus disease, and PsycINFO were searched between January 2020 and 7 April 2021 for multimorbidity and 1 February 2022 for frailty. Quantitative peer-reviewed studies published in English with population-representative samples and validated multimorbidity and frailty tools were considered. Results Overall, 9,701 records were screened by title/abstract and 267 with full text. Finally, 14 studies were retained for multimorbidity (etiological role, n = 2; prognostic, n = 13) and 5 for frailty (etiological role, n = 2; prognostic, n = 4). Only short-term outcomes, mainly mortality, were identified. An elevated likelihood of poorer outcomes was associated with an increasing number of diseases, a higher Charlson Comorbidity Index, different disease combinations, and an increasing frailty level. Discussion Future studies, which include the effects of recent virus variants, repeated exposure and vaccination, will be useful for comparing the possible evolution of the associations observed in the earlier waves.

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Fatores de risco para óbito por COVID-19 no Acre, 2020: coorte retrospectiva

Cited by 10 publications

References 19 publications

SARS-CoV-2 letal: predomínios e lapsos temporais

SARS-CoV-2 letal: predomínios e lapsos temporais

Factors associated with covid-19 deaths in the city of Recife, Pernambuco, Brazil, 2020: a cross-sectional study with “Notifique Aqui” system data

Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies

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