Fatiguing exercise initiated later in life reduces incidence of fibrillation and improves sleep quality in Drosophila

Zheng, Lan; Yue, Feng; Wen, Deng Tai; Wang, Hui; Wu, Xiu Shan

doi:10.1007/s11357-015-9816-7

Cited by 32 publications

(47 citation statements)

References 56 publications

(49 reference statements)

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“…Finally, as is known, exercise training was good for lengthening health-span and reducing the risk of some diseases. In both humans and animals, numbers of studies have confirmed that moderate exercise improves the quality of life and prolongs lifespan [ 16 , 27 , 50 ]; however, obesity leads to a variety of diseases and a bad quality of life [ 4 , 5 ]. This phenomenon confirmed again in our research.…”

Section: Discussionmentioning

confidence: 99%

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Endurance exercise prevents high-fat-diet induced heart and mobility premature aging and dsir2 expression decline in aging Drosophila

et al. 2017

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High-Fat-Diet (HFD)-induced obesity is a major contributor to heart and mobility premature aging and mortality in both Drosophila and humans. The dSir2 genes are closely related to aging, but there are few directed reports showing that whether HFD could inhibit the expression dSir2 genes. Endurance exercise can prevent fat accumulation and reverse HFD-induced cardiac dysfunction. Endurance also delays age-relate functional decline. It is unclear whether lifetime endurance exercise can combat lifetime HFD-induced heart and mobility premature aging, and relieve the harmful HFD-induced influence on the dSir2 gene and lifespan yet. In this study, flies are fed a HFD and trained from when they are 1 week old until they are 5 weeks old. Then, triacylglycerol levels, climbing index, cardiac function, lifespan, and dSir2 mRNA expressions are measured. We show that endurance exercise improves climbing capacity, cardiac contraction, and dSir2 expression, and it reduces body and heart triacylglycerol levels, heart fibrillation, and mortality in both HFD and aging flies. So, lifelong endurance exercise delays HFD-induced accelerated age-related locomotor impairment, cardiac dysfunction, death, and dSir2 expression decline, and prevents HFD-induced premature aging in Drosophila.

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Section: Discussionmentioning

confidence: 99%

“…Most flies continued to respond by climbing throughout the exercise period. The few that failed to climb were actively walking at the inner wall of the vial [ 17 , 27 ]. Flies were exercised in vials with a 2.8-cm inner diameter, rotated at 0.18 rev/s, 0.20 rev/s, 0.18 rev/s, 0.16 rev/s, and 0.14 rev/s.…”

Section: Methodsmentioning

confidence: 99%

Endurance exercise prevents high-fat-diet induced heart and mobility premature aging and dsir2 expression decline in aging Drosophila

et al. 2017

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“…The few that failed to climb were actively walking on the inner wall of the vial. Based on the best exercise program that has been determined, we selected continuous exercise for 2.5 h (Zheng et al, 2015).…”

Section: Nh and Exercise Training Devices And Protocolsmentioning

confidence: 99%

“…Mild NH and modest exercise training can instill beneficial effects on the body. Our research team has explored optimal exercise and NH protocols (Zheng et al, 2015;Wang et al, 2017). The purpose of the present investigation was to study changes in cardiac structure and function and behaviors that include sleep-activity and negative geotaxis of aged flies induced by NH and exercise.…”

Section: Introductionmentioning

confidence: 99%

Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female Drosophila

Wang

Zheng

et al. 2020

Front. Physiol.

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Mild normobaric hypoxia (NH) and modest exercise have multiple beneficial effects on health, but the changes in physiological function induced by NH and/or exercise remain unclear. The purpose of this investigation was to examine the specific effects of NH and/or exercise on cardiac function and myocardial structure and behavior including sleep-activity and negative geotaxis in aged Drosophila. We also assessed the survival rate of flies after hypoxia and/or exercise. One-thousand wild-type w 1118 virgin female flies were randomly divided into four groups and treated with NH and/or exercise from ages 3-6 weeks. We found that exercise remarkably delayed the decline of actin and myosin and the age-related changes in cardiac structure, improved abnormal cardiac contraction, and enhanced the cardiac pumping force by inducing cardiac hypertrophy and delaying deterioration of cardiac contractility and diastolic compliance, and improved abnormal heart contraction. NH also increased the content of actin and myosin, but induced a decrease in heart diameter and heart rate, as well as an increase in the number of mitochondria and deeper sleep, which may be the manifestation of energy saving under long-term hypoxia. Both NH and exercise improved sleep quality and climbing ability of aged flies, as well as extended the maximum life span, which shows the benefits of hypoxia and exercise. Finally, the superposition of NH and exercise did not impart any obvious physiological and behavior improvement. Therefore, it is necessary to further explore the appropriate combination of hypoxia and exercise.

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“…Dropping the enclosures results in the animals being knocked to the bottom of the enclosure, and due to their negative geotaxis response, they will attempt to climb to the top of the enclosure until they are dropped again . The Power Tower is a relatively intense form of exercise, and to induce a more gentle form of exercise, other groups have used partial (Swing Boat) or full rotations (Treadwheel, Rotating Exercise Quantification System [REQS], system developed by the Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province at Hunan Normal University in China) of the animal enclosures to induce exercise. When the animal enclosures are rotated, the orientation of “up” changes, and the animals are stimulated to continue to move, leading to exercise compared to control flies.…”

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confidence: 99%

Drosophila melanogaster, a new model for exercise research

Riddle

2019

Acta Physiologica

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Fatiguing exercise initiated later in life reduces incidence of fibrillation and improves sleep quality in Drosophila

Abstract: As the human body ages,

Cited by 32 publications

References 56 publications

Endurance exercise prevents high-fat-diet induced heart and mobility premature aging and dsir2 expression decline in aging Drosophila

Endurance exercise prevents high-fat-diet induced heart and mobility premature aging and dsir2 expression decline in aging Drosophila

Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female Drosophila

Drosophila melanogaster, a new model for exercise research

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