Fatigue, serum cytokine levels, and blood cell counts during radiotherapy of patients with breast cancer

Geinitz, Hans; Zimmermann, Frank; Stoll, Peter; Thamm, Reinhard; Kaffenberger, W.; Ansorg, Kai; Keller, Monika; Busch, Raymonde; Beuningen, D. van; Molls, M.

doi:10.1016/s0360-3016(01)01657-1

Cited by 165 publications

(165 citation statements)

References 25 publications

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“…[1][2][3]5,14 The current study found that women who performed moderate intensity aerobic exercise during radiation treatment of breast cancer were able to prevent the declines in erythrocyte levels that were experienced by their nontraining peers. This study also found significant positive correlations between changes in peak aerobic capacity and final erythrocyte measures, lending support to the relation between erythrocyte measures and improving physical fitness levels during this time.…”

Section: Discussionmentioning

confidence: 63%

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Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer

Drouin

Young

Beeler

et al. 2006

Cancer

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BACKGROUND.Erythrocyte changes from aerobic exercise training were examined during radiation treatment of breast cancer.METHODS.Twenty sedentary females with breast carcinoma who were ages 35 to 65 years were randomized to aerobic exercise (AE) of walking for 20 to 45 minutes, 3 to 5 times per week, at 50% to 70% of measured maximum heart rates or to placebo stretching (PS) activities 3 to 5 days per week during 7 weeks of radiation treatment. Measures were obtained 1 week before and after the radiation regimen. Serum blood analyses, through complete blood counts, measured red blood cell counts (RBC), hematocrit (HCT), and hemoglobin (HB). Peak aerobic capacity (peak VO2) was measured by exercise testing with oxygen uptake analysis to assess training. A Wilcoxon Mann‐Whitney U test examined changes between groups (P ≤ .05 for significance).RESULTS.AE peak VO2 increased by 6.3% (P = .001) and PS decreased by 4.6% (P = .083). RBC increased in AE from 4.10 to 4.21 million cells/μL and declined in PS from 4.30 to 4.19 million cells/μL; the between‐group differences were significant (P = .014). HCT increased in AE from 38.0% to 38.8% and declined in PS from 37.40% to 36.50%; the between‐group differences were significant (P = .046). HB increased in AE from 12.3 to 12.4 g/dL and declined in PS from 12.25 to 11.77 g/dL; the between‐group differences were significant (P = .009).CONCLUSIONS.The results of the current study suggest that moderate intensity aerobic exercise appears to maintain erythrocyte levels during radiation treatment of breast cancer compared with the declines observed in nontraining individuals. These findings suggest a safe, economical method to improve fitness and maintain erythrocytes in women during radiation treatment of breast cancer. Cancer 2006. © 2006 American Cancer Society.

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Section: Discussionmentioning

confidence: 63%

“…1,2 Declines in erythrocyte levels may be associated with radiation treatment complications that include fatigue, anemia, depression, and diminished physical function. [3][4][5] Reduced erythrocyte levels have also been associated with increased local and regional failure and decreased survival rates in some cancers.…”

mentioning

confidence: 99%

Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer

Drouin

Young

Beeler

et al. 2006

Cancer

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“…An early study conducted with prostate cancer patients documented increases in fatigue and serum levels of IL-1β during radiation therapy (Greenberg et al, 1993), and fatigue was positively correlated with serum levels of IL-6 and other inflammatory markers in a more recent study of breast cancer patients undergoing radiation, although this association appeared to be mediated by body mass index (Wratten et al, 2004). Other studies have shown increases in fatigue but no changes in serum levels of proinflammatory cytokines among women undergoing radiation therapy for breast (Geinitz et al, 2001) or uterine cancer (Ahlberg et al, 2004), and no correlation between fatigue and cytokine levels (Geinitz et al, 2001). These mixed results may be due to constraints of the respective study designs (e.g., small sample sizes, use of non-standard measures to detect cytokine levels; Ahlberg et al, 2004) as well as the focus on cross-sectional associations between cytokine levels and fatigue.…”

Section: Fatigue and Inflammation During Radiation Therapymentioning

confidence: 98%

Cancer-related fatigue: Links with inflammation in cancer patients and survivors

Bower

2007

Brain, Behavior, and Immunity

216

153

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Fatigue is one of the most common and distressing side effects of cancer and its treatment and may persist long after successful treatment completion. Emerging evidence suggests that inflammatory processes may be involved in cancer-related fatigue both during and after treatment. In this review, we consider the evidence for an association between inflammation and fatigue in cancer patients and survivors. Further, we identify potential mechanisms for persistent inflammation, focusing on the HPA axis. Risk factors and treatments for cancer-related fatigue are also discussed.

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“…Some study refuting the association between anemia & fatigue [17][18][19] and some stating that there is a positive association [10] .…”

Section: Anemia and Cancer Relate Fatigue-is The Association Significmentioning

confidence: 99%

Cancer related fatigue-Analysing its causes to find the road map to its treatment- in the Indian scenario

.C¹

2017

JMSCR

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Fatigue, serum cytokine levels, and blood cell counts during radiotherapy of patients with breast cancer

Cited by 165 publications

References 25 publications

Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer

Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer

Cancer-related fatigue: Links with inflammation in cancer patients and survivors

Cancer related fatigue-Analysing its causes to find the road map to its treatment- in the Indian scenario

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