Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer

Drouin, Jacqueline S.; Young, Timothy J.; Beeler, J. Scott; Byrne, Kevin; Birk, Thomas J.; Hryniuk, William M.; Hryniuk, Lynn E.

doi:10.1002/cncr.22267

Cited by 64 publications

(65 citation statements)

References 14 publications

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“…The results of this study agreed with that of Drouin et al, (2006) [10] who found that 7 weeks of moderate intensity aerobic exercise training (walking for 20-45 min, 3-5 times per week, at 50-70% of measured maximum heart rate) increase HCT, Hb, RBC and VO2 peak.…”

Section: Discussionsupporting

confidence: 91%

Impact of Aerobic Exercises on Iron Deficiency Anemia in Girls

Nahas¹

2017

IJPR

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Background: Iron deficiency anemia has recently been ranked as the third leading cause worldwide of loss of disability-adjusted life years for women aged from 15 to 44 years.Objectives: This study was conducted to determine the effect of aerobic exercises on anemia in girls. Participants and methods:Thirty girls participated in this study, their age ranged from 17 to 22 years. They were divided randomly into two groups equal in number: Study group (group A) performed aerobic exercises in form of bicycling (60-70% of HR max ), 30 minutes for each treatment session, for 3 sessions per week, for 12 weeks in addition to iron supplement (Ferro-6) and Control group (group B) received only iron supplement (Ferro-6) for 12 weeks. All participants in both groups (A and B) were assessed pre-and post-treatment through measuring hemoglobin level by blood analysis and scores of total symptoms of anemia by self-administered questionnaire. Results:The results showed that there was a non-statistical significant difference of Hb level between both groups (A and B) post-treatment, where the p values were (>0.05). Although, the percentage of improvement of Hb level was higher in group (A) (8.58%) than in group (B) (5.23%).There was highly statistical significant decrease in scores of total symptoms of anemia and scores of fatigue in group (A) post-treatment when compared with group (B) where the p values were (< 0.01). Also, the percentage of improvement in the total symptoms of anemia was higher in group (A) (42.9%) than in group (B) (16.7%). The percentage of improvement in scores of fatigue was higher in group (A) (50%). Conclusion:It could be concluded that adding aerobic exercises to medication has better effect on Hb level and scores of total symptoms of anemia than medication only.

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Section: Discussionsupporting

confidence: 91%

Impact of Aerobic Exercises on Iron Deficiency Anemia in Girls

Nahas¹

2017

IJPR

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“…Evidence supports the benefit of exercise in managing fatigue during and after treatment for patients with breast cancer and other solid tumors (Courneya & Friedenreich, 1999;Galvao & Newton, 2005 (Drouin et al, 2006) suggest that exercise increases hemoglobin levels. Women receiving radiation treatment for breast cancer (N = 20) were randomly assigned to aerobic exercise or to placebo stretching during the seven-week treatment period.…”

Section: Design-randomized Clinical Trialmentioning

confidence: 98%

“…Although limited by small sample size, results from a recent randomized controlled trial (Drouin et al, 2006) suggest that exercise increases hemoglobin levels. Women receiving radiation treatment for breast cancer (N = 20) were randomly assigned to aerobic exercise or to placebo stretching during the seven-week treatment period.…”

Section: Key Pointsmentioning

confidence: 99%

Effects of Exercise in Combination With Epoetin Alfa During High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma

Coleman

Coon²,

Kennedy³

et al. 2008

Oncology Nursing Forum

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Purpose/Objectives-To determine the effect of aerobic and strength resistance training and epoetin alfa (EPO) therapy on transfusions, stem cell collections, transplantation recovery, and multiple myeloma treatment response. Design-Randomized clinical trial.Setting-A myeloma research and therapy center in the south central United States.Sample-135 patients with multiple myeloma, 120 evaluable.Methods-Random assignment to exercise or usual care groups. All patients received EPO based on an algorithm. Aerobic capacity, using the six-minute walk test, was assessed prior to induction chemotherapy, prior to stem cell mobilization, and following stem cell collection for all patients and before and after transplantation for patients continuing in the study. Data analysis included analysis of variance to compare other outcome variables by groups.Main Research Variables-Number of red blood cell and platelet transfusions during transplantation, number of attempts at and total number of days of stem cell collection, time to recovery after transplantation, and response to intensive therapy for multiple myeloma.Findings-Recovery and treatment response were not significantly different between groups after transplantation. The exercise group had significantly fewer red blood cell transfusions and fewer attempts at stem cell collection. Serious adverse events were similar in each group.Conclusions-Exercise with prophylactic EPO therapy reduces the number of RBC transfusions and attempts at stem cell collection for patients receiving intensive treatment for multiple myeloma.Implications for Nursing-Exercise is safe and has many physiologic benefits for patients receiving multiple myeloma treatment. Key Points • Exercise in combination with epoetin alfa therapy reduced the number of transfusions and the number of attempts at stem cell collection while improving aerobic capacity.• Patients receiving chemotherapy and autologous peripheral blood stem cell transplantation can exercise safely.• Nurses should use exercise as an intervention to reduce the need for transfusions and improve stem cell collection.At least 60% of patients with multiple myeloma are anemic (hemoglobin less than 12 g/dl) at diagnosis (Multiple Myeloma Research Foundation, 2002), and almost all become anemic during treatment, often requiring red blood cell (RBC) transfusions (Knight, Wade, & Balducci, 2004). Epoetin alfa (EPO) increases hemoglobin levels and reduces the need for RBC transfusions in diverse groups of patients with cancer-related anemia (Henry, 2005), particularly patients with multiple myeloma receiving chemotherapy treatment (Barlogie & Beck, 1993).Evidence supports the benefit of exercise in managing fatigue during and after treatment for patients with breast cancer and other solid tumors (Courneya & Friedenreich, 1999;Galvao & Newton, 2005 (Drouin et al., 2006) suggest that exercise increases hemoglobin levels. Women receiving radiation treatment for breast cancer (N = 20) were randomly assigned to aerobic exercise or to placebo stretc...

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“…ESAs increase Hb but they do not induce central (i.e., cardiac output) or peripheral (i.e., Hb extraction and use) adaptations [16,17]. Exercise training can improve these parameters with no expected change in Hb levels.…”

Section: Introductionmentioning

confidence: 99%

Effects of Aerobic Exercise Training in Anemic Cancer Patients Receiving Darbepoetin Alfa: A Randomized Controlled Trial

et al. 2008

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Background. Anemia in patients with solid tumors is a common problem that is associated with impaired exercise capacity, increased fatigue, and lower quality of life (QoL). Erythropoiesis-stimulating agents (ESAs) have been shown to improve these outcomes; however, it is unknown if additional benefits can be achieved with aerobic exercise training.Methods. We conducted a single-center, prospective, randomized, controlled trial in 55 mild-to-moderately anemic patients with solid tumors. Patients were randomized to either darbepoetin alfa alone (DAL, n ‫؍‬ 29) or darbepoetin alfa plus aerobic exercise training (DEX; n ‫؍‬ 26). The DEX group performed aerobic exercise training three times per week at 60%-100% of baseline exercise capacity for 12 weeks. The primary endpoint was QoL assessed by the Functional Assessment of Cancer Therapy-Anemia scale. Secondary endpoints were fatigue, cardio-

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Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer

Cited by 64 publications

References 14 publications

Impact of Aerobic Exercises on Iron Deficiency Anemia in Girls

Impact of Aerobic Exercises on Iron Deficiency Anemia in Girls

Effects of Exercise in Combination With Epoetin Alfa During High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma

Effects of Aerobic Exercise Training in Anemic Cancer Patients Receiving Darbepoetin Alfa: A Randomized Controlled Trial

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