Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients

Cavallari, Michele; Palotai, Miklós; Glanz, Bonnie I.; Egorova, Svetlana; Prieto, Juan Carlos; Healy, Brian C.; Chitnis, Tanuja

doi:10.1177/1352458516635874

Cited by 43 publications

(38 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been reported that the contribution of fatigue to depression severity in patients with MS is higher than in idiopathic depressive disorder . Fatigue is not only associated with patient‐reported HRQoL in cross‐sectional and longitudinal analyses, but it is also a predictor of disease activity and progression in patients with CIS and MS .…”

Section: Discussionmentioning

confidence: 96%

Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

Nourbakhsh

Julián

Waubant

2016

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

Nourbakhsh

Julián

Waubant

2016

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…We reported on the characteristics of the patients eligible for participating in this study in a previous work . The cohort of participants who contributed to the present study largely overlaps that of our previous work (52 out of 60 subjects) . The criteria to allocate subjects to groups were also similar.…”

Section: Methodsmentioning

confidence: 96%

“…On April 28, 2015, we queried clinical and brain MRI data of a population of over 800 MS patients with quality of life assessment from the CLIMB study database (http://www.climbstudy.org). We reported on the characteristics of the patients eligible for participating in this study in a previous work . The cohort of participants who contributed to the present study largely overlaps that of our previous work (52 out of 60 subjects) .…”

Section: Methodsmentioning

confidence: 99%

Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis

Cavallari

Egorova

Healy

et al. 2017

Journal of Neuroimaging

Self Cite

View full text Add to dashboard Cite

Our preliminary findings from a relatively small study sample argue against a potential use of EPVS as early indicator of risk for disease worsening in relapsing-remitting MS patients in a clinical setting. Although the small sample size and clinical 1.5T MRI may have limited our ability to detect a significant effect, we provided estimates of the association of EPVS with clinical and MRI indicators of disease worsening in a well-characterized cohort of MS patients.

show abstract

“…There is some evidence that a shorter time to CDMS diagnosis might correlate with a more severe disease course with more disability. 27 Cavallari et al 28 found that fatigue in patients with MS was predictive for disease worsening. Therefore, we tested whether fatigue present even earlier in the disease also predicts future disability.…”

Section: Discussionmentioning

confidence: 99%

Fatigue after a first attack of suspected multiple sclerosis

et al. 2017

View full text Add to dashboard Cite

Background:Fatigue is reported by more than 75% of multiple sclerosis (MS) patients. In an earlier study, we showed that fatigue is not only a common symptom in patients at time of clinically isolated syndrome (CIS; fatigued 46%) but also predicts subsequent diagnosis of clinically definite multiple sclerosis (CDMS). The course of fatigue after CIS is unknown.Objective:We aimed to explore the long-term course of fatigue after CIS.Methods:In this study, 235 CIS patients, aged 18–50 years, were prospectively followed. Patients filled in the Krupp’s Fatigue Severity Scale (FSS) and the Hospital Anxiety and Depression Scale (HADS) at baseline and annually. After reaching CDMS diagnosis, Expanded Disability Status Scale (EDSS) was obtained annually. Mixed-effects models were used to analyse longitudinal FSS measurements.Results:Fatigue at baseline was an independent predictor for CDMS diagnosis (hazard ratio (HR): 2.6, 95% confidence interval (CI): 1.6–4.4). The evolution of FSS was the same in CIS patients who remained monophasic and patients who were diagnosed with CDMS during follow-up. However, FSS increased by 0.86 units after reaching CDMS diagnosis (p = 0.01). After this increase, the FSS course remained unaltered (p = 0.44).Conclusion:Fatigue, which is often present at time of CIS, probably persists over time and increases after a second attack.

show abstract

Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients

Abstract: Fatigue is a promising indicator of risk for conversion to confirmed moderate-severe disability in RRMS patients.

Cited by 43 publications

References 29 publications

Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study

Evaluating the Association between Enlarged Perivascular Spaces and Disease Worsening in Multiple Sclerosis

Fatigue after a first attack of suspected multiple sclerosis

Contact Info

Product

Resources

About