Fatigue mediates the relationship between physical fitness and quality of life in cancer survivors

Buffart, Laurien M.; Backer, Ingrid C. De; Schep, Goof; Vreugdenhil, Art; Brug, Johannes; Chinapaw, Mai J. M.

doi:10.1016/j.jsams.2012.05.014

Cited by 40 publications

(33 citation statements)

References 23 publications

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“…48 Our results give preliminary support to the implementation of aquatic exercise programs to promote the recovery of functional limitations following initial breast cancer treatment that have been associated with an important reduction in all-cause and competing-cause survival. 49 The current results on mood state partially agree with the results from previous studies using a land-exercise approach.…”

Section: Discussionsupporting

confidence: 52%

The Effectiveness of a Deep Water Aquatic Exercise Program in Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial

Cantarero‐Villanueva

Fernández-Lao

Cuesta‐Vargas

et al. 2013

Archives of Physical Medicine and Rehabilitation

121

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Section: Discussionsupporting

confidence: 52%

The Effectiveness of a Deep Water Aquatic Exercise Program in Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial

Cantarero‐Villanueva

Fernández-Lao

Cuesta‐Vargas

et al. 2013

Archives of Physical Medicine and Rehabilitation

121

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“…; Buffart et al . ), an umbrella term encompassing multiple parameters of life including an individual's physical, functional, emotional and social well‐being (Cella ). The measurement of both QOL and fatigue in this population relies on the use of validated scales and questionnaires specifically designed for this cohort.…”

Section: Introductionmentioning

confidence: 99%

Resistance training improves fatigue and quality of life in previously sedentary breast cancer survivors: a randomised controlled trial

et al. 2015

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The primary aim of this study was to evaluate the benefits of resistance training (RT) on quality of life (QOL) and fatigue in breast cancer survivors as an adjunct to usual care. We recruited 39 women who had survived breast cancer [mean age (y) 51.9 ± 8.8; time since diagnosis (m) 11.6 ± 13.2]. Primary outcomes were fatigue as assessed by the Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT) scale and QOL as assessed by the Functional Assessment of Cancer Therapy - General (FACT-G) scale. ANCOVA was used to assess the change in the primary outcomes while controlling for baseline values, with effect sizes (ES) displayed as partial Eta squared. The experimental group received supervised RT 3 days per week in a university clinic for 16 weeks. Perceptions of fatigue improved significantly in the RT group compared to controls [mean (SD) 6.7 (7.5) points vs. 1.5 (3.7) points], (P = 0.006, ES = 0.20) as did QOL [6.9 (8.5) points vs. 1.6 (4.4) points], (P = 0.015, ES = 0.16). We demonstrated both statistically and clinically important improvements in fatigue and QOL in response to RT in breast cancer survivors.

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“…No prior prospective, randomized exercise and cancer trial has reported mediators of exercise effects on fatigue or attempted to examine mediators within a biobehavioral framework. Fatigue is often a significant and persistent symptom after cancer diagnosis and mediates the benefits of exercise on quality of life (4). Post-cancer fatigue may be caused by physical deconditioning (44), comorbid conditions (35), inflammation (39), psychosocial factors (25), neurotransmitter dysregulation (36), alterations in the hypothalamic-pituitary-adrenal axis function (36), and sleep disruption (36).…”

Section: Introductionmentioning

confidence: 99%

Biobehavioral Factors Mediate Exercise Effects on Fatigue in Breast Cancer Survivors

Rogers

Vicari

Trammell

et al. 2014

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose Examine mediators of fatigue response to an exercise intervention for breast cancer survivors (BCS) in a pilot randomized controlled trial. Methods Postmenopausal BCS (n=46; ≤ Stage II), off primary treatment, and reporting fatigue and/or sleep dysfunction were randomized to a 3-month exercise intervention (160 minutes/week of moderate intensity aerobic walking, twice weekly resistance training with resistance bands) or control group. Six discussion group sessions provided behavioral support to improve adherence. Fatigue, serum cytokines, accelerometer physical activity, cardiorespiratory fitness, sleep dysfunction, and psychosocial factors were assessed at baseline and 3 months. Results Exercise intervention effect sizes for fatigue were: fatigue intensity d=0.30 (p=.34), interference d=−0.38 (p=.22), and general fatigue d=−0.49 (p=.13). Using Freedman-Schatzkin difference-in-coefficients tests, increase in fatigue intensity was significantly mediated by interleukin (IL)-6 (82%), IL-10 (94%), IL-6:IL-10 (49%), and tumor necrosis factor (TNF)-alpha:IL-10 (78%) with reduced sleep dysfunction increasing the relationship between intervention and fatigue intensity rather than mediating intervention effects (−88%). Decrease in fatigue interference was mediated by sleep dysfunction (35%) while IL-10 and pro:anti-inflammatory cytokine ratios increased the relationship between intervention and interference (−25% to −40%). The reduction in general fatigue was significantly mediated by minutes of physical activity (76%), sleep dysfunction (45%), and physical activity enjoyment (40%) with IL-10 (−40%) and IL-6:IL-10 (−11%) increasing the intervention-fatigue relationship. In the intervention group, higher baseline fatigue, anxiety, depression, and perceived exercise barriers interference predicted a greater decline in fatigue interference and/or general fatigue during the intervention. Conclusions Biobehavioral factors mediated and enhanced intervention effects on fatigue while psychosocial factors predicted fatigue response. Further study is warranted to confirm our results and improve understanding of relationships that mediate and strengthen the intervention-fatigue association.

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Fatigue mediates the relationship between physical fitness and quality of life in cancer survivors

Cited by 40 publications

References 23 publications

The Effectiveness of a Deep Water Aquatic Exercise Program in Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial

The Effectiveness of a Deep Water Aquatic Exercise Program in Cancer-Related Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial

Resistance training improves fatigue and quality of life in previously sedentary breast cancer survivors: a randomised controlled trial

Biobehavioral Factors Mediate Exercise Effects on Fatigue in Breast Cancer Survivors

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