Resistance training improves fatigue and quality of life in previously sedentary breast cancer survivors: a randomised controlled trial

Abstract

The primary aim of this study was to evaluate the benefits of resistance training (RT) on quality of life (QOL) and fatigue in breast cancer survivors as an adjunct to usual care. We recruited 39 women who had survived breast cancer [mean age (y) 51.9 ± 8.8; time since diagnosis (m) 11.6 ± 13.2]. Primary outcomes were fatigue as assessed by the Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT) scale and QOL as assessed by the Functional Assessment of Cancer Therapy - General (FACT-G) scale. ANCOVA was used to assess the change in the primary outcomes while controlling for baseline values, with effect sizes (ES) displayed as partial Eta squared. The experimental group received supervised RT 3 days per week in a university clinic for 16 weeks. Perceptions of fatigue improved significantly in the RT group compared to controls [mean (SD) 6.7 (7.5) points vs. 1.5 (3.7) points], (P = 0.006, ES = 0.20) as did QOL [6.9 (8.5) points vs. 1.6 (4.4) points], (P = 0.015, ES = 0.16). We demonstrated both statistically and clinically important improvements in fatigue and QOL in response to RT in breast cancer survivors.

Resistance training interventions across the cancer control continuum: a systematic review of the implementation of resistance training principles

“…Hagstrom et al (2015) employed the traditional ACSM guidelines in breast cancer survivors (with 2 days a week of machine-based exercises: leg extension, machine bench press, back extension) for the first 8 weeks of the study. Participants then transitioned to free weight, barbell compound exercises (squat, deadlift, bench press, etc) for the second 8 weeks 23. It is understood that free weight exercises stimulate muscle tissue to a greater degree than machine-based exercises 96 97.…”

The Effect of Resistance Training on Telomere Length in Women Recovering from Breast Cancer

“…Primary findings from this trial relating to immunological outcomes, muscular strength, quality of life, and fatigue have been previously reported [14,17,18]. Outcome measures were collected at week 0 and 17.…”

“…This study was a post hoc analysis examining the effect of RT on telomere length in this cohort of women. The recruitment of participants, eligibility, exclusion criteria, and randomisation are described elsewhere [14,17,18]. To participate in the initial study, participants must have had a history of histologically confirmed stage I to IIIA breast cancer with no evidence of recurrent disease; age 18-70 years; completed surgery, radiotherapy, and/or chemotherapy; and sedentary (<30 min of structured, continuous moderate-intensity exercise, three times per week, and no current resistance training).…”

“…As methods and findings relating to the testing and training of muscular strength have been previously published [14,17,18] we have not included the details here. These outcomes were used for correlational purposes only.…”

Management of Fatigue Following Breast Cancer Treatment

“…Another study evaluated exercise in previously sedentary breast cancer survivors [65] while another tested resistance exercise in comparison to relaxation control, showing beneficial results [66]. Rehabilitation may also play a role [67].…”