Fatigue in patients with Behçet's syndrome: relationship with quality of life, depression, anxiety, disability and disease activity

İlhan, Birkan; Can, Meryem; Alıbaz-Öner, Fatma; Yılmaz-Öner, Sibel; Polat-Korkmaz, O.; Özen, Gülşen; Mumcu, Gonca; Kremers, Hilal Maradit; Direşkeneli, Haner

doi:10.1111/1756-185x.12839

Cited by 39 publications

(25 citation statements)

References 30 publications

(35 reference statements)

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“…In a Korean study, the proportion of BD patients with depression was 46% . Although Oktayoglu et al detected no significant difference between patients with BD and healthy control subjects in respect of HADS anxiety scores, Ilhan et al showed a significant difference between BD patients and healthy control subjects in HADS anxiety and depression scores, as in the current study . We detected that 40.6% of BD patients had depression and 43.2% had anxiety in this study.…”

Section: Discussioncontrasting

confidence: 45%

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An evaluation of depression, anxiety and fatigue in patients with Behçet’s disease

et al. 2018

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Objectives Behçet's disease (BD) is a type of systemic vasculitis and inflammatory disease of unknown etiology, which is associated with fatigue and lower quality of life (QoL). The aim of this study was to assess the relationship between Behçet's Disease Current Activity Form (BDCAF) and Behçet's Disease Quality of Life (BDQoL), depression, anxiety and fatigue in Behçet's disease. Methods We conducted a cross‐sectional study of 155 BD patients and 107 healthy subjects in a single center over a 1 year period. All participants completed the Multidimensional Assessment of Fatigue (MAF) questionnaire, and the Hospital Anxiety and Depression (HADS) scale. Disease activity in the BD patients was assessed using the BDCAF, and the physician's global assessment (PGA). BD patients also completed the BDQoL questionnaire. Results There was no significant difference in age and gender between the groups. BD patients had significantly higher HADS‐anxiety (HADS‐A), HADS‐depression (HADS‐D) and MAF scores than the healthy control group (P < 0.05). BD patients with active disease had significantly higher MAF and HADS‐A scores compared to inactive BD patients (P < 0.05). MAF scores showed positive correlations with HADS‐A, HADS‐D, BDCAF and BDQoL. Conclusions Fatigue and anxiety are common in clinically active BD patients compared with healthy control subjects and inactive BD patients.

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Section: Discussioncontrasting

confidence: 45%

“…Fatigue can be seen as a symptom of rheumatological and non‐rheumatological diseases . A few recent studies have been conducted about fatigue in BD . BD can affect patients in a negative way and cause fatigue, also reducing quality of life.…”

Section: Introductionmentioning

confidence: 99%

An evaluation of depression, anxiety and fatigue in patients with Behçet’s disease

et al. 2018

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“…The consequences of major organ involvement can largely be eliminated by immunosuppressive medications in BD, whereas mucocutaneous symptoms, as a mild disease spectrum, can remain active under a mild antiinflammatory agent (frequently colchicine)-based protocol (22)(23)(24)(25). In this context, producing new disease-specific or organspecific outcome measures for use in the decision-making process can be helpful in patient management (22)(23)(24)(25)(26)(27)(28)(29). Productivity loss at work and/or in daily life and diseasespecific fears can be considered as outcome measures in cases of BD; however, there have been no data presented to date regarding this issue.…”

Section: Introductionmentioning

confidence: 99%

The assessment of work productivity and activity impairment in Behçet’s disease

Mumcu¹,

Lehimci²,

Fidan³

et al. 2017

Turk J Med Sci

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Background/aim: The aim of this study was to assess the relationships between the course of Behçet's disease (BD), disease-specific fears, and work productivity and activity impairment. Materials and methods:In this cross-sectional study, 110 consecutive BD patients were included. The Work Productivity and Activity Impairment questionnaire was used.Results: In the group of employed patients, 30.41% had missed work during the previous week. The mean percentages of daily activity impairment were higher in patients with musculoskeletal involvement (39.81 ± 33.61%) compared to those without (23.48 ± 32.45%) (P = 0.008). A greater decrease in working hours was observed in patients with eye involvement (45.52 ± 15.29 h) compared to those without (54.15 ± 15.29 h) (P = 0.007). More of the male patients (67.8%) were afraid of losing their jobs compared to females (30%) (P = 0.000). Conclusion:The highest levels of lost productivity and the most severe effects on daily life are consequences of eye and musculoskeletal involvement in the study population. More effective therapeutic approaches are required to improve the working lives of patients with BD. Moreover, male patients had a higher fear of losing their jobs, suggesting a match between the expected clinical course and the predictions of BD patients.

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“…It has a significant impact on economic life of both employed patients and their employers . On this basis, it is necessary to define work limitation‐related factors in patients with chronic diseases to improve work performance of patients …”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] On this basis, it is necessary to define work limitation-related factors in patients with chronic diseases to improve work performance of patients. 2,[6][7][8][9][10][11][12][13][14][15][16] Behçet's syndrome (BS) is a chronic disease presenting as mild disease course regarding mucocutaneous manifestations and musculoskeletal involvement as well as severe disease course with ocular, vascular, central nervous system and gastrointestinal involvement. A severe disease course is commonly seen in males and treated with immunosuppressive medications (IS).…”

Section: Introductionmentioning

confidence: 99%

Predictive factors for work‐day loss in Behçet's syndrome: A multi‐center study

et al. 2019

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Objective The aim of this multi‐center study was to assess predictive factors for work‐day loss as an indirect cost element in Behçet's syndrome (BS). Methods In this cross‐sectional, multi‐center study, 834 BS patients (F/M: 441/393, age mean: 38.4 ± 10.9 years) were included. Data were collected by a questionnaire regarding treatment protocols, disease duration, smoking pattern, frequency of medical visits during the previous year and self‐reported work‐day loss during the previous year. Results Work‐day loss was observed in 16.2% of patients (M/F: 103/32). The percentages of being a smoker (81.8%), using immunosuppressive (IS) medications (82%), and having disease duration <5 years (74%) were higher in male patients with work‐day loss (P < .05). The majority of males (90.9%) had more than four clinic visits during the previous year. Moreover, the mean work‐day loss (30.8 ± 57.7 days) was higher in patients with vascular involvement (56.1 ± 85.9) than those without (26.4 ± 50.6 days) (P = .046). In addition, increased frequency of ocular involvement (25.9%) was also observed in patients with work‐day loss compared to others (8.6%) (P = .059). Conclusion Work‐day loss was associated with both vascular and ocular involvement. Close associations were observed among male gender, early period of the disease, frequent medical visits, being a smoker and treatment with IS medications in patients with work‐day loss.

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Fatigue in patients with Behçet's syndrome: relationship with quality of life, depression, anxiety, disability and disease activity

Abstract: Fatigue is common in clinically active BS patients compared with healthy controls and inactive BS patients. Depression, anxiety and physical dysfunction were significantly associated with fatigue.

Cited by 39 publications

References 30 publications

An evaluation of depression, anxiety and fatigue in patients with Behçet’s disease

An evaluation of depression, anxiety and fatigue in patients with Behçet’s disease

The assessment of work productivity and activity impairment in Behçet’s disease

Predictive factors for work‐day loss in Behçet's syndrome: A multi‐center study

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