Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment

Abstract

We recommend you cite the published version. The publisher's URL is http://dx.doi.org/10. 1016/j.jpainsymman.2009.06.011 Refereed: No (no note) Disclaimer UWE has obtained warranties from all depositors as to their title in the material deposited and as to their right to deposit such material. UWE makes no representation or warranties of commercial utility, title, or fitness for a particular purpose or any other warranty, express or implied in respect of any material deposited.UWE makes no representation that the use of the materials will not infringe any patent, copyright, trademark or other property or proprietary rights. UWE accepts no liability for any infringement of intellectual property rights in any material deposited but will remove such material from public view pending investigation in the event of an allegation of any such infringement. Re: FATIGUE IN GYNAECOLOGICAL CANCER PATIENTS DURING AND AFTER ANTI-CANCER TREATMENTFollowing your recommendation we have merged the original submissions to you journal and have now submitted the manuscript on the above topic via the online submission system for your consideration.All authors have read and approved both manuscripts. I would be most grateful if you could copy all correspondence to my co-authors: Dr Fiona Cramp; fiona.cramp@uwe.ac.uk and Dr Jacqueline Gracey; jh.gracey@ulster.ac.uk as I am currently on maternity leave and may not be able to access my emails on a regular basis. I hope that you will consider the enclosed manuscript for publication in the Journal of Pain and Symptom Management and look forward to receiving your response.

Predictors of fatigue in cancer patients before and after chemotherapy

“…In line with previous studies (e.g., Goedendorp et al, 2008;Prue et al, 2009), psychological factors such as depression and stress play a key role in fatigue before treatment. It is possible that patients' psychological reaction to their cancer diagnosis and apprehension about impending treatments contributed to higher perceived psychological distress and thereby fatigue.…”

“…Those that have been conducted to date have largely been cross-sectional, have focussed on a limited number of possible contributing factors and have produced conflicting findings. Prue et al (2009) reported that distress, physical symptom distress and overall valuation of life predicted fatigue prior to adjuvant therapy in gynaecological cancer patients, while activity levels made no significant contribution. In contrast, Goedendorp et al (2008) reported that physical activity, but not anxiety, predicted severe fatigue before treatment in a large sample of cancer patients with various malignancies, although significant differences in anxiety between fatigued and non-fatigued participants were noted.…”

Age- and sex-standardised prevalence rates of fatigue in a large hospital-based sample of cancer patients

“…It has been shown, in a large longitudinal study of patients with chronic lymphatic leukaemia, that the only predictive variable for persistent fatigue was fatigue at the end of treatment (Heutte et al , 2009). Another study in patients with gynaecological cancer identified 12 months psychological distress as the only relevant correlate of fatigue during anticancer treatment (Prue et al , 2010), which is in essence a similar result. However, although predictor analysis is interesting, the knowledge of prevalence rates in different subgroups is of high clinical importance too.…”

The Symptom Experience of Patients With Cancer

“…In earlier symptom studies of cancer patients, fatigue was the most commonly seen in more than 91% of the patients; this is consistent with earlier studies. 19, 20 …”