Fatigue in chronic disease

Swain, Mark G.

doi:10.1042/cs19990372

Cited by 192 publications

(199 citation statements)

References 75 publications

(110 reference statements)

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“…There is often an interrelatedness of signs and symptoms and both can bring health problems to the attention. However, sometimes the symptoms occur in the absence of signs or they are poorly related to the severity of the disease (Swain, 2000). Nimnuan and co-workers (2001) reported a prevalence of more than 50% of unexplained symptoms in different medical specialties, such as cardiology, gastroenterology, neurology and gynecology.…”

Section: Symptommentioning

confidence: 99%

“…Fatigue encompasses a complex interaction between biological, psychosocial and behavioral processes (Swain, 2000). It is induced by the disease process or treatment regime and is characterized by having an unknown function or purpose, as having multiple additives or unknown causes and is often experienced with no relation to activity or exertion (Piper et al, 1987).…”

Section: Fatiguementioning

confidence: 99%

“…Fatigue is usually perceived as abnormal, unusual or excessive, has an insidious onset, persists over time, is not generally relieved by usual restorative techniques and has a major effect on the individual's activities of daily living and QOL (Piper et al, 1989a). In fact, fatigue is reported as a key factor leading to a decreased QOL in patients with chronic diseases (Swain, 2000).…”

Section: Fatiguementioning

confidence: 99%

“…The basic mechanisms in fatigue are generally divided into two major components: peripheral fatigue from neuromuscular dysfunction and mechanisms leading to energy imbalance and central fatigue that implies alteration in neurotransmitters in serotonergic and noradrenalin pathways and changes in the function of the hypothalamic-pituitary-adrenal axis (HPA), often coexistent with such psychological complaints as anxiety and depression (Swain, 2000, Gutstein, 2001). Other suggested mechanisms of fatigue include alteration in biochemistry with elevated levels of cytokines in plasma, resulting in immune activation.…”

Section: Fatiguementioning

confidence: 99%

“…There is currently no specifi c therapy for treating fatigue in CHF (Swain, 2000). However, some of the hypothesized relating factors may be possible to infl uence either by pharmacological treatment or with care interventions in order to indirectly relieve fatigue or diminish the consequences of fatigue in the patient's daily life.…”

Section: Rationalementioning

confidence: 99%

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Fatigue is a Prevalent and Severe Symptom Associated with Uncertainty and Sense of Coherence in Patients with Chronic Heart Failure

Falk

Swedberg

Gaston‐Johansson

et al. 2007

European Journal of Cardiovascular Nursing

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Although fatigue is a prevalent and distressing symptom in patients with chronic heart failure (CHF), it is an underestimated problem in the care of patients, and consequently, insuffi ciently investigated. The primary aim of this thesis was, therefore, to advance the knowledge from the patients' perspective by describing characteristics of the fatigue experience and its consequences in daily life in patients with CHF. A secondary aim was to investigate the relationships between fatigue and selected physiological and psychological factors associated with fatigue. Both quantitative and qualitative methods have been used and three samples of patients have been interviewed on different occasions. In two of the quantitative studies 93 patients, and in another study 112 patients, consecutively included, were interviewed at the hospital. Fifteen patients were included in the qualitative study. These 15 participants were enrolled when they visited an outpatient clinic and most of them were interviewed in their homes. These interviews were supplemented with the content of an Internet discussion with persons living with CHF.The results of the studies indicated that fatigue embraces the individual's body, emotions and cognitive abilities, forcing the person to physical restrictions that, in turn, perpetuate emotional discomfort. However, the physical sensation of fatigue followed by functional limitations seemed to be the most prevalent and distressing experience in patients with CHF. The patients described fatigue as lacking strength, which was associated in connection with physical efforts and lacking energy, viewed as an annoying sensation after both mental and physical strain. Another dimension of fatigue was described as being sleepy, often with a rapid and unforeseen onset. Consequences of fatigue, such as refraining from daily chores, denying oneself opportunities for rejoice and social isolation, further exaggerated the experience of fatigue. Restorative activities that engaged, absorbed or distracted the patients counteracted these negative consequences. Depressed mood was related to those fatigue dimensions that compromised functional ability and motivation to start any activities, whereas anxiety was associated with cognitive impairment. Feelings of uncertainty were related to physical tiredness, possibly infl icted by limitations in performing activities. Symptom distress that was caused by a number of reported symptoms other than fatigue had a diminutive infl uence on fatigue and separate symptoms that were associated with fatigue were, with the exception of breathlessness, not the fi rst and most pressing symptom reported by the patients. Anemic patients reported more fatigue compared with non-anemic patients and functional status, according to the New York Heart Association (NYHA) functional classifi cation criteria, was associated with those fatigue dimensions that encompassed physical tiredness and reduced functioning.The fi ndings provide new insights on the characteristics of fatigue and its con...

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Section: Symptommentioning

confidence: 99%

Section: Fatiguementioning

confidence: 99%

Section: Fatiguementioning

confidence: 99%

Section: Fatiguementioning

confidence: 99%

Section: Rationalementioning

confidence: 99%

See 3 more Smart Citations

Fatigue is a Prevalent and Severe Symptom Associated with Uncertainty and Sense of Coherence in Patients with Chronic Heart Failure

Falk

Swedberg

Gaston‐Johansson

et al. 2007

European Journal of Cardiovascular Nursing

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Psychological health and well‐being in systemic sclerosis: State of the science and consensus research agenda

Thombs¹,

Lankveld²,

Bassel³

et al. 2010

Arthritis Care & Research

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Illness Perceptions and Fatigue in Systemic Vasculitis

Grayson

Amudala

McAlear

et al. 2013

Arthritis Care & Research

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Objective To compare illness perceptions among patients with different forms of vasculitis, identify risk factors for negative illness perceptions, and determine the association between illness perceptions and fatigue. Methods Participants were recruited from an online registry in vasculitis to complete the revised Illness Perception Questionnaire (IPQ-R). Mean scores on each IPQ-R dimension were compared across types of vasculitis. Cluster analysis and stepwise regression identified predictors of negative illness perception. Fatigue was measured using the general subscale of the Multidimensional Fatigue Inventory (MFI). Patient-reported measures of disease activity and IPQ-R dimensions were assessed in relation to MFI scores using linear regression in sequential, additive models with model-fit comparisons. Results 692 participants with 9 forms of vasculitis completed the IPQ-R. For 6 out of 8 IPQ-R dimensions, there were no significant differences in mean scores between the different vasculitides. Scores in identity and cyclical dimensions were significantly higher in Behçet’s disease compared to other types of vasculitis (13.5 vs 10.7; 4.0 vs 3.2, p<0.05). Younger age (OR=1.04; 95%CI 1.02–1.06), depression (OR=4.94; 95%CI 2.90–8.41), active disease status (OR=2.05; 95%CI 1.27–3.29), and poor overall health (OR=3.92; 95%CI 0.88–17.56) were associated with negative illness perceptions. Sequential models demonstrated that IPQ-R dimensions explained an equivalent proportion of variability in fatigue scores compared to measures of disease activity. Conclusion Illness perceptions are similar across different types of vasculitis, and younger age is a risk factor for negative illness perceptions. Illness perceptions explain differences in fatigue scores beyond what can be explained by measures of disease activity.

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Fatigue in chronic disease

Cited by 192 publications

References 75 publications

Fatigue is a Prevalent and Severe Symptom Associated with Uncertainty and Sense of Coherence in Patients with Chronic Heart Failure

Fatigue is a Prevalent and Severe Symptom Associated with Uncertainty and Sense of Coherence in Patients with Chronic Heart Failure

Psychological health and well‐being in systemic sclerosis: State of the science and consensus research agenda

Illness Perceptions and Fatigue in Systemic Vasculitis

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