Fatigue durabiity of a novel disc nucleus repair system

Yuksel, Umit; Walsh, Steven P; Curd, David; Black, Kirby S.

doi:10.1016/s1529-9430(02)00233-4

Cited by 6 publications

(2 citation statements)

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“…Nucleus prosthesis geometrical and interfacial configurations have aimed to account for the following aspects with varying emphasis [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]:…”

Section: Nucleus Prosthesis Review a Review Of Recent Nucleus Prosthe...mentioning

confidence: 99%

Geometrical & Interfacial Modulation of a Biomimetic Spinal Implant

Lok

Boughton

Kishen

et al. 2009

JBBTE

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The nucleus of a spinal disc is seamlessly connective and protectively supportive of the joint within which it is enveloped. A range of nucleus prosthesis configurations have been proposed and applied with some success. Those that have demonstrated clinical efficacy have approximated physiological form and function using established biomaterials while preserving key anatomical structures. The minimally invasive biostable, biomimetic Columna Disc Device (CDD) partial spinal disc replacement has been developed to clinical trial stage. It mimics the geometry and response of the nucleus that it replaces. While the implant configuration and materials have been set, the geometry and interfacial properties of this prosthesis may be modulated to account for versatility in surgical deployment, implant stiffness, and subsequent long-term tissue remodelling response. FEA models were developed to study effects of implant jacket geometry and surface properties on implant deployment and biomechanics. Studded and dimpled textures provide a method for increasing surface area to diffuse jacket-filler interfacial stress and similar for the implant-tissue junction. Surface texture design elements observed in nature can protect against delamination and interlayer slippage. This is the case with adherent outer layers of human skin. A textured implant design is also proposed to guard against third body wear by housing debris remote of wear sites and by reducing sliding. The periodically varying strain fields provided by the textured jacket may also help mitigate for tears by diverting and arresting micro-fissures. Increasing friction at the implant-tissue interface to the point of tissue-attachment was shown to increase the stiffness of the implant in axial-loading. In contrast, increasing bulk surface area is expected to contribute to a decrease in implant stiffness. This is, however, dependent on the intimacy and properties of interfacing tissues.

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Section: Nucleus Prosthesis Review a Review Of Recent Nucleus Prosthe...mentioning

confidence: 99%

Geometrical & Interfacial Modulation of a Biomimetic Spinal Implant

Lok

Boughton

Kishen

et al. 2009

JBBTE

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“…Since then, injectable biomaterials or scaffolds have been developed that may act as a substitute for the disc nucleus pulposus, such as hyaluronic acid, fibrin glue, alginate, elastin-like polypeptides, collagen type I gel and others. A number of patents have been issued concerning various injectable biomaterials that may have utility for nucleus augmentation including: cross-linkable silk elastin copolymer [17,25,56], polyurethane-filled balloons [4,24], aldehyde cross-linked bovine serum albumin [68], collagen-PEG [52]; chitosan [21]; various injectable synthetic polymers [39]; recombinant bioelastic materials [61]; light-curable PEG polymers and other multicomponent precursor systems [30,31]. Several groups are actively pursuing the development of an injectable biomaterial for use in the intervertebral disc.…”

Section: Injectable Biomaterials Optionsmentioning

confidence: 99%

Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc

2006

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The objectives of augmentation of the nucleus pulposus following disc removal are to prevent disc height loss and the associated biomechanical and biochemical changes. Flowable materials may be injected via a small incision, allowing minimally invasive access to the disc space. Fluids can interdigitate with the irregular surgical defects and may even physically bond to the adjacent tissue. Injectable biomaterials allow for incorporation and uniform dispersion of cells and/or therapeutic agents. Injectable biomaterials have been developed that may act as a substitute for the disc nucleus pulposus. Our work has focused on the evaluation of a recombinant protein copolymer consisting of amino acid sequence blocks derived from silk and elastin structural proteins as an injectable biomaterial for augmentation of the nucleus pulposus. This implant, NuCore TM Injectable Nucleus is being developed by Spine Wave (Shelton, CT). The NuCore

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Nucleus Replacement

Pelletier

Walsh

2011

Comprehensive Biomaterials

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Fatigue durabiity of a novel disc nucleus repair system

Cited by 6 publications

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Geometrical & Interfacial Modulation of a Biomimetic Spinal Implant

Geometrical & Interfacial Modulation of a Biomimetic Spinal Implant

Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc

Nucleus Replacement

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