Fatigue Damage of Collagenous Tissues: Experiment, Modeling and Simulation Studies

Abstract

Mechanical fatigue damage is a critical issue for soft tissues and tissue-derived materials, particularly for musculoskeletal and cardiovascular applications; yet, our understanding of the fatigue damage process is incomplete. Soft tissue fatigue experiments are often difficult and time-consuming to perform, which has hindered progress in this area. However, the recent development of soft-tissue fatigue-damage constitutive models has enabled simulation-based fatigue analyses of tissues under various conditions. Computational simulations facilitate highly controlled and quantitative analyses to study the distinct effects of various loading conditions and design features on tissue durability; thus, they are advantageous over complex fatigue experiments. Although significant work to calibrate the constitutive models from fatigue experiments and to validate predictability remains, further development in these areas will add to our knowledge of soft-tissue fatigue damage and will facilitate the design of durable treatments and devices. In this review, the experimental, modeling, and simulation efforts to study collagenous tissue fatigue damage are summarized and critically assessed.

The effects of walking intervention on preventing neck pain in office workers: A randomized controlled trial

“…These fatigue-induced changes are thought to play a role in the pathogenesis of body tissues, leading to neck pain. 28,29 Increased daily walking steps in sedentary workers may indirectly reflect frequent rest breaks, allowing sufficient tissue recovery to occur. In addition, previous studies have shown that exercise, for example, cycling, can increase blood flow or tissue oxygenation to non-working or inactive muscles.…”

“…If there is insufficient time for allowing tissue capacity regeneration, the muscle fatigue may further reduce available capacity. These fatigue‐induced changes are thought to play a role in the pathogenesis of body tissues, leading to neck pain . Increased daily walking steps in sedentary workers may indirectly reflect frequent rest breaks, allowing sufficient tissue recovery to occur.…”

The analysis of oauses of bioprosthetio valve dysfunction: the example of «UniLine» bioprosthesis

“…Кроме того, вследствие значительной асимметричной деформации стоек каркаса с изменением угла наклона и растяжением биологической ткани под действием интенсивной циклической нагрузки в процессе функционирования в организме пациента в створках биопротеза происходит перераспределение напряжения. При этом циклическое напряжение неизбежно приводит к усталости биоматериала, которая локализована в куполе и комиссуральной зоне створок [12]. По данным настоящего исследования, основная масса кальцификатов была расположена именно в зонах, более подверженных усталости.…”

Concise Review: Tissue Engineering of Urinary Bladder; We Still Have a Long Way to Go?

“…Considering the urinary tract's hydrodynamic features, matters of concern are potential determinants of long‐term biomaterial fatigue, that is, continuous flow and related volume extensibility during the storage phase. Before implementation, a fatigue test could easily reveal the durability of the fabricated neo‐tissue; however, no published studies characterized fatigue in the preclinical tissue engineered graft . Of utmost importance in reconstructive therapies dedicated to young patients with a long‐life expectancy is fatigue analysis.…”