Fatigue and fatigue-related symptoms in patients treated for different causes of hypothyroidism

Louwerens, Marloes; Appelhof, Bente C.; Verloop, Herman; Medici, Marco; Peeters, Robin P.; Visser, Theo J.; Boelen, Anita; Fliers, Eric; Smit, Johannes W. A.; Dekkers, Olaf M.

doi:10.1530/eje-12-0501

Cited by 38 publications

(29 citation statements)

References 41 publications

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“…Regardless of this result, hypothyroidism is less likely an aetiology of fatigue in our AITD patients. A similar finding was reported in a recently published study of Louwerens et al (30), in which autoimmune hypothyroid patients had significantly higher levels of fatigue compared to the patients with differentiated thyroid carcinoma, but it could not be attributed to clinical or thyroid hormone parameters.…”

Section: Fatigue and Thyroid Autoantibodiessupporting

confidence: 90%

Fatigue in Patients with Autoimmune Thyroid Diseases

Jovanović

Miletić-Drakulić

Toncev

et al. 2017

Serbian Journal of Experimental and Clinical Research

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Fatigue is a common feature in a wide variety of chronic infl ammatory and autoimmune diseases, but fatigue in autoimmune thyroid disease (AITD) has not been investigated so far. Th e aim of this study was to examine fatigue in patients with AITD and to analyse the correlation between fatigue and the serum concentrations of thyroid antibodies, thyroid function and depression. Th is cross-sectional clinical study included 62 patients with increased concentrations of thyroperoxidase antibodies (TPOAbsThe concentration of TPOAbs was determined by a radioligand assay (TPO-Ab-CT, Cis-Biointernational, France) according to the manufacturer's instructions. The lower detection limit for this assay was 8 U/ml. The measured TPOAb concentrations were analysed towards the value of 130 U/ml, whereas autoantibody concentrations higher than 130 U/mL were considered "increased".The concentration of TgAb was determined by a competitive "one-step" radioimmunoassay (TgAb I step, CisBiointernational, France). The method was calibrated against the WHO First International Reference Preparation CRM 65/93 and had an analytical detection limit of 6.0 IU/ml. Autoantibody concentrations higher than 30 IU/mL were considered "increased".The concentration of free thyroxine (fT4) was determined by a radioimmunoassay (Cis-Biointernational, France). The detection limit for this assay was 0.5 pg/ml, and the reference range was 7-18 pg/ml.The concentration of thyrotropin (TSH) was determined by an immunoradiometric assay (IRMA TSH, Zemun, Serbia), with a detection limit of 0.056 mIU/L and reference range of 0.3-5.5 mIU/L.

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Section: Fatigue and Thyroid Autoantibodiessupporting

confidence: 90%

Fatigue in Patients with Autoimmune Thyroid Diseases

Jovanović

Miletić-Drakulić

Toncev

et al. 2017

Serbian Journal of Experimental and Clinical Research

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“…A more sensitive TSH receptor (TSHR-Glu 727) increases the ability of neurons to adjust intracellular thyroid hormone levels, thereby affecting neuropsychological functioning. [17][18][19] Among menstruating females, 54.5% had irregular periods with complaints of oligomenorrhoea as well as menorrhagea. Both hyper and hypothyroidism may result in menstrual disturbances.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of general and cutaneous manifestations of hypothyroidism: a single center experience in Odisha

Kumar

Aslami

2016

Int J Res Dermatol

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Background: Endocrine diseases may induce manifestation through the skin. Hypothyroidism is known to cause a wide range of general and skin manifestations. Dermatologists may commonly see skin disorders that reflect an underlying hypothyroid state. The objective of the study was to evaluate varied general and cutaneous manifestations of hypothyroidism.Methods: A hospital based descriptive clinical study was conducted in the department of Dermatology, Venerology and Leprosy, MKCG Medical College, Berhampur, Odisha. Diagnosed cases of hypothyroidism were included as the study subjects. An informed consent was taken from each patient. Institutional ethics committee of the college approved the Study.Results: 320 patients of hypothyroidism were evaluated. Maximum patients 115 (35.9%) were among 31-40 years of age group. Male to female ratio was 1:5.7. The percentage of hypothyroid patients who complained of constipation, fatigue, Cold intolerance, weight gain and neck swelling was 75.0%, 57.2%, 50.9%, 35.9% and 31.9% respectively. Among females, 54.5% were having irregular menses. The most common cutaneous symptom was dry course skin (75.9%), followed by diffuse hair loss (50.9%), puffy oedema (48.1%), decreased sweating (11.9%) and yellow skin (9.1%). The most observed cutaneous sign was xerosis (66.9%), followed by alteration in skin texture (55.0%). Some patients showed more than one cutaneous signs. The most common hair changes in our patients were diffuse hair loss (55.9%), followed by course scalp hair (29.4%).Conclusions: The interaction between hypothyroidism and skin is of profound clinical importance. So, dermatologists need to be alert of the ways in which these two organ systems interact, so that early diagnosis and management of hypothyroidism may ensue.

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“…This suggests that T 3 administration is not necessary to maintain serum T 3 values at their endogenous prethyroidectomy levels. Moreover, persistent fatigue and fatigue-related symptoms are more pronounced in autoimmune hypothyroid patients compared with patients with hypothyroidism after total thyroidectomy, representing a disease-specific decrease in quality of life (Louwerens et al, 2012). There are also indications that patients with relatively high antithyroid peroxidase antibody levels in blood perceive an increased symptom load and a decreased quality of life (Ott et al, 2011).…”

Section: Discussionmentioning

confidence: 99%