Fatigue Among Short- and Long-Term Thyroid Cancer Survivors: Results from the Population-Based PROFILES Registry

Husson, Olga; Nieuwlaat, Willy-Anne; Oranje, W.A.; Haak, Harm R.; Poll‐Franse, Lonneke V. van de; Mols, Floortje

doi:10.1089/thy.2013.0015

Cited by 75 publications

(61 citation statements)

References 44 publications

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“…Fatigue is the most common symptom reported by cancer patients before and during treatment, and can continue for years after completion of treatment (Bower and Lamkin, 2013; Husson et al, 2013; Minton et al, 2012). It often co-occurs with depression, (Bower et al, 2011; Kim et al, 2012; Pertl et al, 2013) and reduces quality of life (Vissers et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function

Norden

Bicer

Clark

et al. 2015

Brain, Behavior, and Immunity

110

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Cancer patients frequently suffer from fatigue, a complex syndrome associated with loss of muscle mass, weakness, and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, during treatment, and persists for years after treatment. CRF negatively influences quality of life, limits functional independence, and is associated with decreased survival in patients with incurable disease. Currently there are no effective treatments to reduce CRF. The aim of this study was to use a mouse model of tumor growth and discriminate between two main components of fatigue: loss of muscle mass/function and altered mood/motivation. Here we show that tumor growth increased fatigue- and depressive-like behaviors, and reduced body and muscle mass. Decreased voluntary wheel running activity (VWRA) and increased depressive-like behavior in the forced swim and sucrose preference tests were evident in tumor-bearing mice within the first two weeks of tumor growth and preceded the loss of body and muscle mass. At three weeks, tumor-bearing mice had reduced grip strength but this was not associated with altered expression of myosin isoforms or impaired contractile properties of muscles. These increases in fatigue and depressive-like behaviors were paralleled by increased expression of IL-1β mRNA in the cortex and hippocampus. Minocycline administration reduced tumor-induced expression of IL-1β in the brain, reduced depressive-like behavior, and improved grip strength without altering muscle mass. Taken together, these results indicate that neuroinflammation and depressed mood, rather than muscle wasting, contribute to decreased voluntary activity and precede major changes in muscle contractile properties with tumor growth.

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Section: Introductionmentioning

confidence: 99%

Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function

Norden

Bicer

Clark

et al. 2015

Brain, Behavior, and Immunity

110

View full text Add to dashboard Cite

show abstract

“…We recently published separate papers on the prevalence of CRF of specific cancer types including understudied cancers such as thyroid cancer and multiple myeloma, and with comparison to a normative population [25][26][27]. The PROFILES registry is also a very suitable resource to identify patterns of fatigue in a large heterogeneous group of cancer survivors as all participants completed a standard fatigue questionnaire.…”

Section: Introductionmentioning

confidence: 99%

Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry

Husson

Mols

Poll-Franse

et al. 2015

Support Care Cancer

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Fatigue levels are substantial in (long-term) cancer survivors and vary depending on cancer type, time since diagnosis, age, gender, treatment with chemotherapy, number of comorbid conditions, educational level, and partnership. Since significantly more cancer survivors feel fatigued in comparison with the normative population, appropriate information, assessment, and interventions for fatigue are needed during or after oncologic treatment. Furthermore, focus on better control or management of comorbid conditions of cancer survivors is recommended.

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“…Uma das facetas avaliadas nesse domínio refere-se à mobilidade. De acordo com a literatura prévia e os resultados desse estudo, pode-se concluir que a diminuição dos escores desta faceta está relacionada à fadiga e diminuição de energia referida por esses pacientes, que prejudicam sua locomoção e interferem em sua vida diária (24) .…”

Section: Discussionunclassified

“…A espiritualidade e a religiosidade são destacadas como um mecanismo fundamental de enfrentamento após a descoberta de uma doença maligna (22)(23)(24)(25)(26)(27)(28) , com potencial para facilitar a adaptação psicológica à neoplasia e reduzir sintomas depressivos (28) . Pesquisa mostra que (20) a religiosidade e a espiritualidade são estratégias eficazes para enfrentar o sofrimento da patologia oncológica, assim como fonte de esperança e ressignificação do sentido da vida.…”

Section: Discussionunclassified

Avaliação Da Qualidade De Vida De Indivíduos Com Carcinoma Bem Diferenciado De Tireoide Pelo Whoqol-100

Furino

2017

Cogitare Enferm.

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RESUMO: Este estudo objetivou avaliar a qualidade de vida de pacientes em acompanhamento clínico por carcinoma bem diferenciado de tireoide, por meio do questionário WHOQOL-100. Trata-se de estudo quantitativo realizado entre março de 2015 e março de 2017 em São Carlos, SP, Brasil, descritivo e transversal, que avaliou 280 indivíduos, sendo 70 com carcinoma de tireoide e 210 controles, divididos em ≤45 e >45 anos. Os resultados mostraram que o grupo carcinoma de tireoide ≤ 45 anos apresentou prejuízo nos domínios físico (p=0,0032) e nível de independência (p<0,0001), e melhora no domínio meio ambiente (0,0138 RESUMEN: Este estudio objetivó evaluar la cualidad de vida de pacientes en seguimiento clínico por carcinoma bien diferenciado de tiroides, mediante el cuestionario WHOQOL-100. Se trata de estudio cuantitativo desarrollado entre marzo del 2015 y marzo del 2017 en São Carlos, SP, Brasil, descriptivo y trasversal, que evaluó 280 individuos, siendo 70 con carcinoma de tiroides y 210 controles, divididos en ≤45 y >45 años. Los resultados mostraron que el grupo carcinoma de tiroides ≤ 45 años presentó perjuicio en los dominios físico (p=0,0032) y nivel de independencia (p<0,0001), y mejora en el dominio medio ambiente (0,0138). El grupo con carcinoma de tiroides > 45 años presentó mejora en el dominio medio ambiente (0,0002) y calidad de vida global (p=0,00146) con relación a los controles. Eses hallazgos, frutos de un análisis amplio de la calidad de vida de pacientes con carcinoma diferenciado de tiroides, pueden contribuir a la comprensión de las repercusiones de la enfermedad y su tratamiento.

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Fatigue Among Short- and Long-Term Thyroid Cancer Survivors: Results from the Population-Based PROFILES Registry

Abstract: Short- and long-term TC survivors report higher levels of fatigue than an age- and sex-matched normative population do. Both TC-specific HRQoL and psychological distress were associated with fatigue.

Cited by 75 publications

References 44 publications

Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function

Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function

Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry

Avaliação Da Qualidade De Vida De Indivíduos Com Carcinoma Bem Diferenciado De Tireoide Pelo Whoqol-100

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