Fatigue – a symptom in endometriosis

Ramin-Wright, Annika; Schwartz, A Kohl; Geraedts, Kirsten; Rauchfuß, Martina; Wölfler, M; Haeberlin, Felix; Orelli, Stephanie von; Eberhard, Markus; Imthurn, Bruno; Imesch, Patrick; Fink, Daniel; Leeners, Brigitte

doi:10.1093/humrep/dey115

Cited by 107 publications

(116 citation statements)

References 39 publications

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“…The contribution of pelvic pain (PP) to the psychosocial status and the quality of life (QoL) of women with endometriosis has been extensively addressed [6][7][8][9][10]. Additionally, chronic fatigue, i.e., the perception of physical tiredness and lack of energy distinct from sadness or weakness, is another endometriosis-related symptom, as recently identified in women with endometriosis [11]. However, the role of chronic fatigue on patients' lives has been poorly addressed, although a few qualitative studies have indicated that affected women ascribed social and work impairments to fatigue [12,13].…”

Section: Introductionmentioning

confidence: 99%

Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis

Mundo-López

Ocón‐Hernández

San-Sebastián

et al. 2020

IJERPH

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Aim: To analyze the levels of chronic fatigue in Spanish women with endometriosis and its relationship with their psychosocial status and quality of life (QoL). Methods: A total of 230 Spanish women with a clinical diagnosis of endometriosis were recruited. Chronic fatigue (Piper Fatigue Scale) and pelvic pain (Numeric Rating Scale) were evaluated. An on-line battery of validated scales was used to assess psychosocial status [Hospital Anxiety and Depression Scale, Scale for Mood Assessment, Pain Catastrophizing Scale, Pittsburgh Sleep Quality Index, Gastrointestinal Quality of Life Index, Female Sexual Function Index and Medical Outcomes Study-Social Support Survey] and QoL [Endometriosis-Health Profile questionnaire-30]. Associations between fatigue and both psychosocial and QoL outcomes were explored through multivariate regression models. Results: One-third and one-half of women showed moderate and severe fatigue, respectively. Fatigue was associated with higher anxiety and depression, poorer sleep quality, poorer sexual functioning, worse gastrointestinal health, higher catastrophizing thoughts, higher anger/hostility scores and lower QoL (p-values < 0.050). Moreover, fatigue and catastrophizing thoughts showed a mediating effect on the association between pelvic pain and QoL. Conclusion: This work reveals the important role of fatigue in the association between pain, psychosocial status, and QoL of Spanish women with endometriosis.

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Section: Introductionmentioning

confidence: 99%

Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis

Mundo-López

Ocón‐Hernández

San-Sebastián

et al. 2020

IJERPH

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“…There is no standard definition of "long-term" treatment for endometriosis, and dienogest 2 mg was approved on the basis of the clinical development program, which included studies lasting up to 15 months [24][25][26][27][28] . Although there have been few interventional studies since to investigate treatment durations beyond 15 months, supportive evidence for long-term dienogest treatment is available from a number of studies (Table 1) [1][2][3][4][5][6][7][8][9][10][11][12][13] . These studies show that administration of dienogest for up to 5 years is effective in preventing recurrence of disease and/or symptoms following surgery, and reducing endometriosis-associated pain 19,[29][30][31][32][33][34][35][36][37] .…”

Section: Efficacy With Long-term Dienogest Therapy For Endometriosismentioning

confidence: 99%

“…Pain is considered to be the defining symptom of endometriosis and can include dysmenorrhea, noncyclic pelvic pain, and/or dyspareunia 2,7 . Endometriosis can be both physically and emotionally debilitating, thereby significantly reducing a woman's quality of life [8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Use of dienogest in endometriosis: a narrative literature review and expert commentary

Murji

Biberoğlu²,

Leng

et al. 2020

Current Medical Research and Opinion

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Objective: Endometriosis affects up to 10% of women of reproductive age, and the main goal of treatment is to relieve symptoms. Progestins have been the mainstay of endometriosis suppression, of which dienogest has become an important option in many parts of the world. This is an expert literature review, with recommendations on the use of dienogest in the context of various clinical considerations when treating endometriosis. Methods: A search of PubMed was conducted for papers published between 2007 and 2019 on the use of dienogest in endometriosis. Experts reviewed these and included those they considered most relevant in clinical practice, according to their own clinical experience. Results: Evidence regarding the long-term use (>15 months) of dienogest for the management of endometriosis is presented, with experts concluding that the efficacy of dienogest should be assessed primarily on its impact on pain and quality of life. Fertility preservation, the option to avoid or delay surgery, and managing bleeding irregularities that can occur with this treatment are also considered. Counseling women on potential bleeding risks before starting treatment may be helpful, and evidence suggests that few women discontinue treatment for this reason, with the benefits of treatment outweighing any impact of bleeding irregularities. Conclusions: Overall, the evidence demonstrates that dienogest offers an effective and tolerable alternative or adjunct to surgery and provides many advantages over combined hormonal contraceptives for the treatment of endometriosis. It is important that treatment guidelines are followed and care is tailored to the woman's individual needs and desires.

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“…1,3 Anxiety and depression are identified as recurrent psychological symptoms in women with endometriosis. [4][5][6][7] Such symptoms can compromise the daily life of endometriosis patients, affecting the family, social, professional, economic and personal areas, which justifies a multi professional intervention. 4,[7][8][9][10][11][12] The multi professional intervention can count on doctors specialized in pain, reproduction or gynecology, as well as psychologists, physiotherapists, acupuncturists, nutritionists, among others.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7] Such symptoms can compromise the daily life of endometriosis patients, affecting the family, social, professional, economic and personal areas, which justifies a multi professional intervention. 4,[7][8][9][10][11][12] The multi professional intervention can count on doctors specialized in pain, reproduction or gynecology, as well as psychologists, physiotherapists, acupuncturists, nutritionists, among others. 6,7,13,14 Thus, the present study intends, through literature review, to identify the results obtained in individual or group psychotherapeutic intervention directed to the women with the diagnosis of endometriosis care.…”

Section: Introductionmentioning

confidence: 99%

Endometriosis and psychological interventions

Inocente¹,

Soares²

2018

Hum. Reprod. Arch.

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Objectives: The objective of this systematic review was to analyze the results of psychological interventions as an aid in the medical treatment of endometriosis symptoms. Methods: This systematic review study conducted in 2016, in the databases Idex Psi, Lilacs, PePsic, PubMed, Scielo and Science Direct. The descriptors used were "endometriosis AND psychology", "endometriosis AND health" and "endometriosis AND support group". The inclusion criteria were to contain in the title the word "endometriosis" and to describe in the summary or in the tittle of the article on psychological analysis, intervention and/or recommendations for the treatment of women with endometriosis; or contain "endometriosis" in the title and be published in scientific journals of Psychology. Exclusion criteria referred in the title to as exclusively medical terms or to only one symptom of endometriosis. Results: The search resulted in 13 articles and three categories: Bibliographic review, Context analysis and Psychological intervention. Conclusions: The results indicated a lack of bibliography related to the condition of endometriosis and Psychology simultaneously, mainly regarding to psychological intervention. These data demonstrated the necessity for studies that investigate and develop intervention strategies for women in this condition.

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Fatigue – a symptom in endometriosis

Abstract: ClinicalTrials.gov, NCT 02511626.

Cited by 107 publications

References 39 publications

Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis

Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis

Use of dienogest in endometriosis: a narrative literature review and expert commentary

Endometriosis and psychological interventions

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