Fate and proliferation of typical antibiotic resistance genes in five full-scale pharmaceutical wastewater treatment plants

Wang, Jilu; Mao, Daqing; Mu, Quanhua; Luo, Yi

doi:10.1016/j.scitotenv.2015.05.046

Cited by 123 publications

(43 citation statements)

References 45 publications

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“…The results of this work showed that when normalized against 16S rRNA gene copies, the concentrations of sulfonamide and trimethoprim resistance genes were 1-2 log lower in an AnMBR system than in its aerobic counterpart. These observations, along with those of Wang et al [73], reinforce the concept that ARG abundances can be effectively reduced by anoxic or anaerobic conditions [83]. Furthermore, the work of Harb et al [74] is an example of how the combination of anaerobic digestion can be complimented by the advantages of MBR-based treatment for overall improved ARG removal capacity.…”

Section: The Role Of Membrane-based Treatment On Antibiotic Resistancsupporting

confidence: 60%

“…The previously discussed study by Wang et al additionally showed that, for the same influent wastewater, aerobic sludge ARG concentrations were significantly higher than those of both an anaerobic digester and an expanded granular sludge bed (EGSB) reactor (anaerobic), implying that there may be potential advantages to combining anaerobic processes with membrane-based treatment [73]. This concept was specifically investigated in a recent study by Harb et al, which compared ARG abundance reduction by anaerobic versus aerobic sludge-based MBR treatment systems [74].…”

Section: The Role Of Membrane-based Treatment On Antibiotic Resistancmentioning

confidence: 93%

“…Tetracycline-associated resistance gene LRVs were also significantly higher than in other treatment plants. A similar study by Wang et al that investigated ARG abundance in pharmaceutical wastewater treatment systems further determined that membrane separation of aerobic sludge removed up to 99.8% of ARGs and was more effective than secondary clarification [73]. Both MBRs in the aforementioned studies employed membranes with pore sizes in the ultrafiltration (UF) range, which are generally larger than the average plasmid that would represent extracellular ARGs.…”

Section: The Role Of Membrane-based Treatment On Antibiotic Resistancmentioning

confidence: 96%

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Anaerobic Membrane Bioreactor Effluent Reuse: A Review of Microbial Safety Concerns

Harb¹,

Hong²

2017

Fermentation

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Broad and increasing interest in sustainable wastewater treatment has led a paradigm shift towards more efficient means of treatment system operation. A key aspect of improving overall sustainability is the potential for direct wastewater effluent reuse. Anaerobic membrane bioreactors (AnMBRs) have been identified as an attractive option for producing high quality and nutrient-rich effluents during the treatment of municipal wastewaters. The introduction of direct effluent reuse does, however, raise several safety concerns related to its application. Among those concerns are the microbial threats associated with pathogenic bacteria as well as the emerging issues associated with antibiotic-resistant bacteria and the potential for proliferation of antibiotic resistance genes. Although there is substantial research evaluating these topics from the perspectives of anaerobic digestion and membrane bioreactors separately, little is known regarding how AnMBR systems can contribute to pathogen and antibiotic resistance removal and propagation in wastewater effluents. The aim of this review is to provide a current assessment of existing literature on anaerobic and membrane-based treatment systems as they relate to these microbial safety issues and utilize this assessment to identify areas of potential future research to evaluate the suitability of AnMBRs for direct effluent reuse.

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Section: The Role Of Membrane-based Treatment On Antibiotic Resistancsupporting

confidence: 60%

Section: The Role Of Membrane-based Treatment On Antibiotic Resistancmentioning

confidence: 93%

Section: The Role Of Membrane-based Treatment On Antibiotic Resistancmentioning

confidence: 96%

See 1 more Smart Citation

Anaerobic Membrane Bioreactor Effluent Reuse: A Review of Microbial Safety Concerns

Harb¹,

Hong²

2017

Fermentation

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“…) Takanami et al, 2012) (Funke et al, 2016;Prasse et al, (Huang et al, 2010;Roberts and Thomas, 2006) (Guerra et al, 2014;Roberts and Thomas, 2006) (Guerra et al, 2014;Kasprzyk-Hordern et al, 2009;Roberts and Thomas, 2006 (Munir et al, 2011;Wang et al, 2015) INF: Influent wastewater (U): Urine. PFU: Plaque forming units (measure of number of infectious particles).UTI: Urinary tract infection *Via sequencing…”

mentioning

confidence: 99%

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level

Sims

Kasprzyk-Hordern

2020

Environment International

447

348

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Infectious diseases are acknowledged as one of the most critical threats to global public health today. Climate change, unprecedented population growth with accelerated rates of antimicrobial resistance, have resulted in both the emergence of novel pathogenic organisms and the re-emergence of infections that were once controlled. The consequences have led to an increased vulnerability to infectious diseases globally. The ability to rapidly monitor the spread of diseases is key for prevention, intervention and control, however several limitations exist for current surveillance systems and the capacity to cope with the rapid population growth and environmental changes. Wastewater-Based Epidemiology (WBE) is a new epidemiology tool that has potential to act as a complementary approach for current infectious disease surveillance systems and an early warning system for disease outbreaks. WBE postulates that through the analysis of population pooled wastewater, infectious disease and resistance spread, the emergence of new disease outbreak to the community level can be monitored comprehensively and in real-time. This manuscript provides critical overview of current infectious disease surveillance status, as well as it introduces WBE and its recent advancements. It also provides recommendations for further development required for WBE application as an effective tool for infectious disease surveillance.

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“…In addition, sulfonamide (sulI and sulII)), tetracycline (tet(O), tet(T), tet(M), tet(Q), and tet(W), b-lactam (bla OXA-1 , bla OXA-2 , and bla OXA-10 ), and macrolide (ermB) resistance genes were detected based on quantitative PCR analysis in typical pharmaceutical wastewater treatment systems (Zhai et al, 2016). The maximum concentrations of ARGs detected in the final effluents of pharmaceutical WWTPs were up to 3.68 Â 10 6 copies/mL by Wang et al (2015) and 2.36 Â 10 7 copies/mL by Zhai et al (2016), respectively, which were much higher than the concentration in MWTPs as revealed by Mao et al (2015).…”

Section: Medical and Pharmaceutical Wastewatermentioning

confidence: 99%

Biological HRPs in wastewater

Jia

Zhang

2020

High-Risk Pollutants in Wastewater

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Fate and proliferation of typical antibiotic resistance genes in five full-scale pharmaceutical wastewater treatment plants

Cited by 123 publications

References 45 publications

Anaerobic Membrane Bioreactor Effluent Reuse: A Review of Microbial Safety Concerns

Anaerobic Membrane Bioreactor Effluent Reuse: A Review of Microbial Safety Concerns

Future perspectives of wastewater-based epidemiology: Monitoring infectious disease spread and resistance to the community level

Biological HRPs in wastewater

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