Fatal Staphylococcus saprophyticus Native Valve Endocarditis in an Intravenous Drug Addict

Singh, Vipul; Raad, Issam

doi:10.1093/infdis/162.3.783

Cited by 26 publications

(13 citation statements)

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“…The most convincing laboratory findings include the rapid isolation of CNS from more than one blood culture, a high intensity of bacteremia (CFU per milliliter), and the presence of the same strain(s) in sequential isolations (4,158). Generally, in patients with suspected bacterial endocarditis, three blood cultures are sufficient to isolate the etiologic agent (141 (15,195), S. epidermidis (43,158), S. saprophyticus (282), and S. saccharolyticus (313).…”

Section: Specimen Collection and Processingmentioning

confidence: 99%

Update on clinical significance of coagulase-negative staphylococci

1994

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The clinical significance of coagulase-negative Staphylococcus species (CNS) continues to increase as strategies in medical practice lead to more invasive procedures. Hospitalized patients that are immunocompromised and/or suffering from chronic diseases are the most vulnerable to infection. Since CNS are widespread on the human body and are capable of producing very large populations, distinguishing the etiologic agent(s) from contaminating flora is a serious challenge. For this reason, culture identification should proceed to the species and strain levels. A much stronger case can be made for the identification of a CNS etiologic agent if the same strain is repeatedly isolated from a series of specimens as opposed to the isolation of different strains of one or more species. Strain identity initially can be based on colony morphology, and then one or more molecular approaches can be used to gain information on the genotype. Many of the CNS species are commonly resistant to antibiotics that are being indicated for staphylococcal infections, with the exception of vancomycin. The widespread use of antibiotics in hospitals has provided a reservoir of antibiotic-resistant genes. The main focus on mechanisms of pathogenesis has been with foreign body infections and the role of specific adhesins and slime produced by Staphylococcus epidermidis. Slime can reduce the immune response and opsonophagocytosis, thereby interfering with host defense mechanisms. As we become more aware of the various strategies used by CNS, we will be in a better position to compromise their defense mechanisms and improve treatment.

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Section: Specimen Collection and Processingmentioning

confidence: 99%

Update on clinical significance of coagulase-negative staphylococci

1994

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“…There are also several case reports of infections in young girls 13 . The more severe complications include acute pyelonephritis, septicemia, nephrolithiasis and endocarditis 7,14,15 . S. saprophyticus can also cause UTI in males of all ages ; the organism has been isolated in young boys, male homosexuals, and elderly men with indwelling urinary catheters 16,17 .…”

Section: Introductionmentioning

confidence: 99%

Urinary Tract Infections Caused by Staphylococcus saprophyticus and their antimicrobial sensitivity pattern in Young Adult Women

Jhora¹,

Paul²

2011

Bangladesh J Med Microbiol

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The present study was conducted to observe the antibiotic sensitivity pattern of isolated S. saprophyticus from urine samples of patients admitted in inpatient department or visited the out patient department of Sir Salimullah Medical College & Mitford Hospital (SSMC& MH) Dhaka from October 2002 to September 2003. Among the isolates, Esch. coli was the most predominant (82.61%) urinary pathogens followed by S. saprophyticus (7.01%). 93.10% S. saprophyticus was isolated from females of which highest (44.82%) rate of isolation was among female of 18-45 years age group. Rate of isolation was also high (41.38%) among female of <18 years age group. All strains of S. saprophyticus (100%) were sensitive to Imipenem. High sensitivity was also observed to gentamicin (86.20%) and ceftriaxone (72.41%). Ciprofloxacin was found to be sensitive against 68.96% isolates. Sensitivity of ceftazidime, cephalexin and cloxacillin were 65.51%, 55.17% and 55.17% respectively. However, most of the S. saprophyticus are resistant to ampicillin, nalidixic acid and cotrimoxazole. So, the present study illustrates that physicians and microbiologists must be aware that S saprophyticus is an important cause of UTIs in young women and there is a need for continuous evaluation of common antibiotics used in the therapy of uropathogens.

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“…saprophyticus is the second most common uropathogen following Escherichia coli, causing uncomplicated UTIs in young females in USA, Canada and Scandinavian countries. The most severe complications include acute pyelonephritis [4], septicemia [5], nephrolithiasis [6] and endocarditis [7]. Wallmark [8] isolated S. saprophyticus from the urine of 173 out of 787 (22%) consecutive females with bacteriuria.…”

Section: Introductionmentioning

confidence: 99%